Antidiarrheal activity of the extracts of Valeriana jatamansi Jones on castor oil-induced diarrhea mouse by regulating multiple signal pathways

Ma, Yulei; Wu, Zi-Mei; Liu, Xiao; Lan, Jiang-Er; Zai, Wenjing; Jin, Xin; Xie, Haiyang; Mu, Quanquan; Liu, Hongrui

doi:10.1016/j.jep.2022.115560

Cited by 9 publications

(4 citation statements)

References 43 publications

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“…The primary laxative component is believed to be s side A (SA) [28]. In this study, the symptoms observed in the experimental group consistent with those of SDD, indicating the successful establishment of the model research has demonstrated that diarrhea is typically accompanied by intestinal infla tion, severe dehydration, and intestinal barrier damage [29,30]. Decreased express…”

Section: Discussionsupporting

confidence: 55%

“…In this study, the symptoms observed in the experimental group were consistent with those of SDD, indicating the successful establishment of the model. Prior research has demonstrated that diarrhea is typically accompanied by intestinal inflammation, severe dehydration, and intestinal barrier damage [29,30]. Decreased expression of tight junction (TJ) proteins such as ZO-1 and Occludin can weaken the intestinal epithelium integrity and cause colitis [31][32][33].…”

Section: Discussionmentioning

confidence: 99%

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Pingwei San Ameliorates Spleen Deficiency-Induced Diarrhea through Intestinal Barrier Protection and Gut Microbiota Modulation

et al. 2023

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Pingwei San (PWS) has been used for more than a thousand years as a traditional Chinese medicine prescription for treating spleen-deficiency diarrhea (SDD). Nevertheless, the exact mechanism by which it exerts its antidiarrheal effects remains unclear. The objective of this investigation was to explore the antidiarrheal efficacy of PWS and its mechanism of action in SDD induced by Rhubarb. To this end, UHPLC-MS/MS was used to identify the chemical composition of PWS, while the body weight, fecal moisture content, and colon pathological alterations were used to evaluate the effects of PWS on the Rhubarb-induced rat model of SDD. Additionally, quantitative polymerase chain reaction (qPCR) and immunohistochemistry were employed to assess the expression of inflammatory factors, aquaporins (AQPs), and tight junction markers in the colon tissues. Furthermore, 16S rRNA was utilized to determine the impact of PWS on the intestinal flora of SDD rats. The findings revealed that PWS increased body weight, reduced fecal water content, and decreased inflammatory cell infiltration in the colon. It also promoted the expression of AQPs and tight junction markers and prevented the loss of colonic cup cells in SDD rats. In addition, PWS significantly increased the abundance of Prevotellaceae, Eubacterium_ruminantium_group, and Tuzzerella, while decreasing the abundance of Ruminococcus and Frisingicoccus in the feces of SDD rats. The LEfSe analysis revealed that Prevotella, Eubacterium_ruminantium_group, and Pantoea were relatively enriched in the PWS group. Overall, the findings of this study indicate that PWS exerted a therapeutic effect on Rhubarb-induced SDD in rats by both protecting the intestinal barrier and modulating the imbalanced intestinal microbiota.

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Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Pingwei San Ameliorates Spleen Deficiency-Induced Diarrhea through Intestinal Barrier Protection and Gut Microbiota Modulation

et al. 2023

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“…(Shu et al, 2016 ), Pueraria lobata ( Willd .) Ohwi (Liu, Xu, et al, 2021 ), Valeriana jatamansi Jones (Ma et al, 2022 ), Rhodiola crenulata ( Hook. f. et Thoms .)…”

Section: Introductionmentioning

confidence: 99%

Relationship among Chinese herb polysaccharide (CHP), gut microbiota, and chronic diarrhea and impact of CHP on chronic diarrhea

Xue,

Mei,

Wang

et al. 2023

Food Science & Nutrition

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Chronic diarrhea, including diarrhea‐predominant irritable bowel syndrome (IBS‐D), osmotic diarrhea, bile acid diarrhea, and antibiotic‐associated diarrhea, is a common problem which is highly associated with disorders of the gut microbiota composition such as small intestinal bacterial overgrowth (SIBO) and so on. A growing number of studies have supported the view that Chinese herbal formula alleviates the symptoms of diarrhea by modulating the fecal microbiota. Chinese herbal polysaccharides (CHPs) are natural polymers composed of monosaccharides that are widely found in Chinese herbs and function as important active ingredients. Commensal gut microbiota has an extensive capacity to utilize CHPs and play a vital role in degrading polysaccharides into short‐chain fatty acids (SCFAs). Many CHPs, as prebiotics, have an antidiarrheal role to promote the growth of beneficial bacteria and inhibit the colonization of pathogenic bacteria. This review systematically summarizes the relationship among gut microbiota, chronic diarrhea, and CHPs as well as recent progress on the impacts of CHPs on the gut microbiota and recent advances on the possible role of CHPs in chronic diarrhea.

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“…This extensive usage across diverse cultures and historical periods underscores the plant's versatility and perceived medicinal value, making it a revered botanical in traditional medicine systems worldwide. [8][9][10]…”

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confidence: 99%

Nardostachys jatamansi: A Review on Extraction Isolation Bioactivities of Phytoconstituents Chemical Structures and Traditional Uses

Mane,

Jagtap,

Chitlange

et al. 2024

IJPQA

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Nardostachys jatamansi, commonly known as “jatamansi,” is a perennial herbaceous plant renowned for its medicinal properties. The rhizomes of N. jatamansi have been traditionally used in various medicinal practices owing to their therapeutic benefits. This abstract delves into the extraction process and isolation of phytoconstituents from N. jatamansi rhizomes, elucidating the extraction, purification, and structural analysis methods. The extraction of bioactive compounds from N. jatamansi rhizomes commonly employs soxhlet extraction, percolation, and maceration extraction techniques. These methods enable the efficient extraction of phytoconstituents from the plant material, ensuring optimal yield and purity. N. jatamansi has a rich history of traditional uses, including its application in Ayurvedic and traditional medicine systems for its diverse therapeutic properties. The rhizomes are reputed for their efficacy in treating various ailments, such as anxiety, insomnia, epilepsy, and gastrointestinal disorders. Furthermore, the bioactivity of isolated phytoconstituents from N. jatamansi rhizomes has been extensively studied. These bioactive compounds exhibit a range of pharmacological activities, including neuroprotective, anti-inflammatory, antioxidant, and antimicrobial effects. Structural elucidation of these phytoconstituents through advanced analytical techniques provides insights into their chemical composition and potential therapeutic mechanisms. The study concludes that the extraction, purification, and structural analysis of phytoconstituents from N. jatamansi rhizomes contribute to understanding its medicinal properties and pave the way for developing novel therapeutics with diverse pharmacological applications.

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Antidiarrheal activity of the extracts of Valeriana jatamansi Jones on castor oil-induced diarrhea mouse by regulating multiple signal pathways

Cited by 9 publications

References 43 publications

Pingwei San Ameliorates Spleen Deficiency-Induced Diarrhea through Intestinal Barrier Protection and Gut Microbiota Modulation

Pingwei San Ameliorates Spleen Deficiency-Induced Diarrhea through Intestinal Barrier Protection and Gut Microbiota Modulation

Relationship among Chinese herb polysaccharide (CHP), gut microbiota, and chronic diarrhea and impact of CHP on chronic diarrhea

Nardostachys jatamansi: A Review on Extraction Isolation Bioactivities of Phytoconstituents Chemical Structures and Traditional Uses

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