Antidiabetic and hypolipidemic efficacy of skin and seed extracts of Momordica cymbalaria on alloxan induced diabetic model in rats

Elangovan, Abbirami; Abinaya, S.; Siva, Durairaj; Jeyadevi, R.; Lakshmanan, Dinesh Kumar; Ravichandran, Guna; Nambirajan, Gayathri; Thilagar, Sivasudha

doi:10.1016/j.jep.2019.111989

Cited by 27 publications

(21 citation statements)

References 42 publications

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“…Generally, lipid disorders are related to diabetes and this leads to cardiovascular conditions, including elevated levels of TC, TG, LDL, and reduced HDL (Elangovan et al 2019). Similar to the report by Sasongko et al (2020), alloxan-induced diabetes triggered a considerable rise in serum MDA and a significant decreased in antioxidant enzymes in this study.…”

Section: Discussionsupporting

confidence: 88%

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The Hypolipidemic Effect of Mountain Papaya and Bitter Melon Fruit Ethanolic Extract in Diabetic Rats

Sasongko

Lestari²,

Indasari³

et al. 2022

J.Tropical Biodiversity Biotechnology

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Traditional medicine has been developed rapidly throughout the world to treat hyperlipidemia. However, the use of a single compound in hyperlipidemia treatment usually have low efficacy. Therefore, a combination of ingredients is bound to have more synergistic impact in therapy. This research aimed to examine the hypolipidemic potential of mountain papaya (MPE) and bitter melon fruit ethanolic extract (BME) in alloxan-induced rats. Forty rats divided into eight groups were used in this study. Groups are divided into normal control, negative control, positive control, as well as MPE and BME groups which divided into single doses and three combination doses. Induction of 150 mg/kg alloxan intraperitoneally were performed to generate a model of diabetes and hyperlipidemia. The treatment was carried out for four weeks of the experiment. The single and combination doses of both extracts sufficiently exhibited hypolipidemic activity (p < 0.05). The levels of lipid profiles total such as cholesterol, triacylglycerides, low-density lipoprotein, high-density lipoprotein, and very high-density lipoprotein were decreased after MPE and BME administration (p < 0.05). The combination of MPE and BME also has hypolipidemic action equivalent to simvastatin. The single and combined doses of mountain papaya, as well as bitter melon fruit ethanolic extracts, have the potential to improve the biochemical (lipid profile) modifications of alloxan-induced.

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Section: Discussionsupporting

confidence: 88%

“…Plants with flavonoid have hypolipidemic activity related to inhibition of HMG-CoA reductase and hence mevalonate production (Ziaee et al 2009;Ling et al 2020). Mountain papaya (Vasconcellea pubescens) and bitter melon (Momordica charantia) are two Indonesian plants known to exhibit this activity (Elangovan et al 2019;Gao et al 2019).…”

Section: Introductionmentioning

confidence: 99%

The Hypolipidemic Effect of Mountain Papaya and Bitter Melon Fruit Ethanolic Extract in Diabetic Rats

Sasongko

Lestari²,

Indasari³

et al. 2022

J.Tropical Biodiversity Biotechnology

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“… 70 Increased STC, STG, LDL, and HDL levels, as well as decreasing HDL levels, are usually related to diabetes, which leads to the development of cardiovascular illnesses. 71 The current investigation found a consistent positive connection between hyperglycemia and hyperlipidaemia. Hyperlipidemia makes diabetic people more vulnerable to cardiovascular disease.…”

Section: Discussionsupporting

confidence: 74%

Evaluation of Anti-Diabetic and Anti-Hyperlipidemic Activities of Hydro-Alcoholic Crude Extract of the Shoot Tips of Crinum abyssinicum Hochst. ex A. Rich (Amaryllidaceae) in Mice

Tegegne¹,

Mekuria²,

Birru³

2022

JEP

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Background Despite the availability of synthetic antihyperglycaemic medications on the market, diabetes is on the rise. Though not scientifically proven, the Crinum abyssinicum Hochst. ex A. Rich. (Amaryllidaceae) has been used traditionally to treat diabetes. Crinum abyssinicum was tested in mice to see if it had anti-diabetic and anti-hyperlipidemic properties. Methods The hydro-alcoholic extract of Crinum abyssinicum shoot tips doses (100 mg/kg, 200 mg/kg, and 400 mg/kg) were administered to normoglycemic, oral glucose-loaded mice, and single and repeated dose-treated streptozotocin-induced diabetic model. Then, the blood glucose levels were measured for normoglycemic, oral glucose loaded and single dose treated streptozotocin model. Whereas in repeated dose-treated streptozotocin induced diabetic model, blood glucose level, body weight, and lipid profiles were measured. Results After oral administration, all extract doses (100 mg/kg (p < 0.01), 200 mg/kg (p < 0.001), and 400 mg/kg (p < 0.001)) significantly reduced blood glucose level of normal mice as compared to the control group. Significant reduction of post-prandial glucose was achieved with crude extract at a tested dose of 100 mg/kg (p < 0.05) both at 1st and 2nd hours; 200 mg/kg (p < 0.01) at the 1st hour and (p < 0.001) 2nd hours, and 400 mg/kg (p < 0.001) at the 1st and 2nd hours as compared to the negative control. In diabetic mice, the crude extract 200 mg/kg and 400 mg/kg; and glibenclamide 5 mg/kg significantly reduced (p < 0.001) blood glucose level on the 14th day as compared to the negative control. All doses of crude extract significantly improved the lipid profiles and the bodyweight of diabetic mice. Conclusion These findings revealed that the hydro-alcoholic extract of Crinum abyssinicum shoot tips possess significant antihyperglycemic, antihyperlipidemic, and body weight improvements in streptozotocin-induced diabetic mice. Besides, it showed hypoglycaemic and anti-hyperglycaemic activities on normoglycemic and oral glucose loaded mice, respectively. These justify the claimed use of the plant in ameliorating diabetes mellitus in Ethiopian folk medicine.

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“…The plant extract‐treated animals also showed significantly improved lipid profile in diabetic animals as compared to the disease control group. These hepatoprotective and hypolipidemic effects of the Pine nut extracts may be attributed to the regeneration of pancreatic islets, decrease in glycogenolysis, and improvement in insulin secretion or decreasing insulin resistance (Elangovan et al, 2019). The plant extracts showed a significant antioxidant and radical scavenging activity that protected the animals from liver injury (Kinoshita, Inoue, Nakama, Ichiba, & Aniya, 2007).…”

Section: Discussionmentioning

confidence: 99%

Chemical characterization, antioxidant evaluation, and antidiabetic potential of Pinus gerardiana (Pine nuts) extracts

et al. 2020

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Methanolic and ethyl acetate extracts of pine nuts were evaluated for in vitro antioxidant and inhibition of alpha‐amylase activities. Pine nut extracts were orally administered to alloxan monohydrate‐induced diabetes in mice at 250, 500, and 750 mg/kg. Both extracts showed a significant antioxidant and inhibition of alpha‐amylase activities. Animal studies showed a decline in fasting blood glucose, hyperlipidemia, and weight loss in diabetic mice. The administration of plant extracts decreased the blood glucose level during the oral glucose tolerance test. Histopathological examination showed a decrease in alloxan‐induced lesions in the pancreas, liver, and kidney of animals treated with pine nut extracts. Furthermore, pine nut extract ameliorated oxidative stress‐induced hepatotoxicity in diabetic mice. The presence of quercetin, gallic acid, vanillic acid, benzoic acid, syringic acid, m‐coumaric acid, and other phenolic compounds might be related to hypoglycemic, alpha‐amylase inhibitory, antioxidant, and antihyperlipidemic potential of pine nut extracts. Practical applications Dry fruits are rich in dietary nutrients, minerals, and phytochemicals that can be used to treat and prevent lifestyle disease. Pine nuts are edible and have economic importance in addition to several traditional uses such as diuretic, antiseptic, expectorant, antibacterial, antiviral, antifungal, antihypertensive, and antineuralgic properties. This study was conducted to investigate the pine nut extracts for their antioxidant and antidiabetic potentials using in vitro methods and animal disease model. The findings of the present study suggest that the extracts of Pine nuts may be helpful in treating hyperglycemia during diabetes and prevent its complications such as hepatic damage, nephrotoxicity, weight loss, and hyperlipidemia.

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Antidiabetic and hypolipidemic efficacy of skin and seed extracts of Momordica cymbalaria on alloxan induced diabetic model in rats

Cited by 27 publications

References 42 publications

The Hypolipidemic Effect of Mountain Papaya and Bitter Melon Fruit Ethanolic Extract in Diabetic Rats

The Hypolipidemic Effect of Mountain Papaya and Bitter Melon Fruit Ethanolic Extract in Diabetic Rats

Evaluation of Anti-Diabetic and Anti-Hyperlipidemic Activities of Hydro-Alcoholic Crude Extract of the Shoot Tips of Crinum abyssinicum Hochst. ex A. Rich (Amaryllidaceae) in Mice

Chemical characterization, antioxidant evaluation, and antidiabetic potential of Pinus gerardiana (Pine nuts) extracts

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