Antidiabetic and Antioxidant Effect of Cinnamon in poorly Controlled Type-2 Diabetic Iraqi Patients: A Randomized, Placebo-Controlled Clinical Trial

Abstract

Aim:To determine the effect of cinnamon on fasting blood glucose, hemoglobin (Hb) A1c, and oxidative stress markers in poorly controlled type 2 diabetes.Patients and Methods:A total of 25 type 2 diabetic patients of both sexes, aged 49.1 ± 6.0, treated only with hypoglycemic agent sulfonylurea (glibenclamide) were randomly assigned to receive either 1 g of cinnamon or placebo daily for 12 weeks.Results:A highly significant (P ≤ 0.001) reduction (10.12%) of fasting blood glucose level after 6 and 12 weeks of treatment 10.12% and 17.4%, respectively, compared to baseline value and to placebo group at corresponding duration. Meanwhile, the value of glycosylated Hb reduced in cinnamon treated group by (2.625%) and (8.25%) after 6 and 12 weeks, respectively, although this reduction was non-significant compared to baseline value. Concerning the oxidative stress markers, the level of serum glutathione showed highly significant (P ≤ 0.001) elevation after 12 weeks as compared to baseline value and placebo group at corresponding duration, malondialdehyde serum level decreased after treatment of diabetic patients with cinnamon resulted in highly significant (P ≤ 0.001) reduction after 6 and 12 weeks compared to placebo group, but when compared to baseline value, there is a (15%) reduction only after 12 weeks of treatment which was considered highly significant (P ≤ 0.001) change, Finally, administration of cinnamon to diabetic patients for 12 weeks resulted in significant (P ≤ 0.05) elevation of superoxide dismutase level.Conclusion:Intake of 1 g of cinnamon for 12 weeks reduces fasting blood glucose and glycosylated Hb among poorly controlled type 2 diabetes patients, as well as, there is improvement in the oxidative stress markers, indicating the beneficial effect of adjuvant cinnamon as anti-diabetic and antioxidant along with conventional medications to treat poorly controlled type 2 diabetes mellitus.

Postprandial Glucose Levels Are Better Associated with the Risk Factors for Diabetes Compared to Fasting Glucose and Glycosylated Hemoglobin (HbA1c) Levels in Elderly Prediabetics: Beneficial Effects of Polyherbal Supplements—A Randomized, Double-Blind, Placebo Controlled Trial

“…A recent study showed that daily intake of 1g of cinnamon for 12 weeks reduced fasting blood glucose and HbA1c levels in middle-aged type 2 diabetic patients [36]. The antidiabetic effects of cinnamon were reported to increase glucose uptake, improve insulin sensitivity in peripheral tissues, improve glycogen synthesis in the liver, restore pancreatic islets dysfunction, slow gastric emptying rates, and improve diabetic renal and brain disorders through multiple signaling pathways, including the PPARs, PI3K/IRS-1, GLUT4, and Nrf2 pathways [37].…”

Diabet Hastalarında Bitkisel Ürün Kullanımı

“…Çalışmamızda en çok kullanılan bitkisel ürün tarçın bulunmuştur. Yapılan çalışmalarda, 12 hafta boyunca 1g tarçın alan tip 2 diyabet hastalarında kan glikozunun ve glikozile hemoglobinin düştüğü ve tarçının antidiyabetik, antioksidan etkilerinin olduğu görülmüştür (10). Yapılan başka bir çalışmada, tarçının 1, 3 veya 6 g günlük alınması serum glukoz, trigliserid, LDL kolesterol, total kolesterol düzeylerini tip 2 diyabetli hastalarda düşürdüğü görülmüştür (11).…”

Nutraceutical Improves Glycemic Control, Insulin Sensitivity, and Oxidative Stress in Hyperglycemic Subjects: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

“…10 Furthermore, recent research indicated that cinnamon intake can reduce FBG and HbA1C levels in type 2 diabetes patients. 11 An experimental study demonstrated that ALA stimulated glucose uptake to a similar extent to insulin in isolated human skeletal myocytes and adipocytes via the activation of the insulin signaling pathway. 38 In addition, ALA appears to have an insulin-sensitizing and lipid-lowering effect in obese individuals predisposed to type 2 diabetes mellitus.…”

“…10 Moreover, the consumption of cinnamon can reduce FBG and HbA1C among poorly controlled type 2 diabetes patients, as well as improve oxidative stress markers. 11 Alpha-lipoic acid (ALA) is a natural antioxidant. It is known to exert beneficial actions against oxidative stress caused by hyperglycemia.…”