Antidiabetic activity of extracts of Anacardium occidentale Linn. leaves on n -streptozotocin diabetic rats

Abstract

Anacardium occidentale L. (Anacardiaceae) is used in South Cameroon as well as in other tropical countries by traditional practitioners as a folk remedy for treatment of diabetes mellitus. We demonstrated the antidiabetic potential of the plant extracts in n-streptozotocin diabetic rats. The aim of the current study was to investigate the antidiabetic effects of ethanol extract of leaves of A. occidentale on neonatal streptozotocin diabetic rats.Two day old neonates were injected with 100 mg/kg of streptozotocin. At the end of the experimental period of 30 days, reduction in the fasting blood glucose levels, serum insulin, glycated hemoglobin levels, serum lipid parameters, and renal function biomarkers were estimated in the control and treated rats. Histopathological examination of liver, kidney and pancreas were also carried out.On administration of 100 mg/kg of plant extract, blood glucose levels of the rats showed 8.01% and 19.25% decrease in the fasting blood glucose levels on day 15 and day 30, respectively. The administration of extract showed that the effects of extract treatment are comparable to treatment with the standard drug Pioglitazone.These results demonstrate significant antidiabetic potential of the ethanol extract of leaves of A. occidentale, justifying the use of plant in the indigenous system of medicine. Further studies for investigating the specific compound(s) responsible for such beneficial role in diabetes would open new outlook in the therapy of type 2 diabetes.

Effets antidiabétiques de l’extrait aqueux de <i>Ageratum conyzoïdes</i> (Astéraceae) chez les rats rendus diabétiques par pancréatectomie partielle et évaluation de leurs paramètres hématologiques

“…Cet effet observé est similaire aux effets de plusieurs plantes de la pharmacopée traditionnelle telles que Momordica charantia L. (Cucurbitaceae) (Rammal et al, 2009), Anacardium occidentale (Anacardiaceae) (Jaiswal et al, 2016), Anabasis articulata (Chenopodiaceae) (Kambouche et al, 2011) sur la glycémie des rats diabétiques. En effet, Rammal et al (2009) ont démontré dans leurs études que l'extrait aqueux des fruits frais de Momordica charantia L., plante antidiabétique (Laleye et al, 2015) entraine une diminution de la glycémie chez les souris rendues diabétiques par l'alloxane à la dose de 200 mg/kg p.c.…”

“…En effet, Rammal et al (2009) ont démontré dans leurs études que l'extrait aqueux des fruits frais de Momordica charantia L., plante antidiabétique (Laleye et al, 2015) entraine une diminution de la glycémie chez les souris rendues diabétiques par l'alloxane à la dose de 200 mg/kg p.c. Ce constat a été également fait par Jaiswal et al (2016), sur des rats rendus diabétiques par la n-streptozotocine en présence d'extrait éthanolique de feuilles de Anacardium occidentale. Enfin Kambouche et al (2011) en étudiant l'extrait butanolique du β-sitoglucoside contenu dans Anabasis articulata sur le diabète expérimental induit par le glucose chez des souris, ont conclu que cet extrait baisse la glycémie.…”

Amelioration of Metabolic Syndrome in High Fat Fed Mice by Hydro-Ethanolic Fraction of M. longifolia (J. Koenig)

“…Research show that herbal extracts have a significant role in amelioration of the metabolic syndrome. 3,23 Elevated body weight, imbalanced glucose homeostasis and regulated lipid profile are a few of the primary key characteristics of metabolic disorder like as obesity, diabetes or cardiac diseases. The increased shift in these haematological and body parameters can cause serious damage to body cells leading to organ failures.…”

“…The increased shift in these haematological and body parameters can cause serious damage to body cells leading to organ failures. [22][23] High fat containing items are mostly used diet in today's population. Its regular and high intake will be the cause of many diseases in coming era, hence its balance is one of the major concern.…”

“…Several researchers reported an increase in body weight as important criteria in high fat diet induced diabetic murine. [13][14]23 In this study, it was observed that regular intake of high fat diet leads to increase in body weight and fat deposition. All the groups showed similar weight enhancement up to 3 weeks of study.…”