Antidepressants synergize with chemotherapy against cancer stem cells

Melino, Gerry

doi:10.18632/aging.100848

Cited by 2 publications

(2 citation statements)

References 7 publications

(12 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At the molecular level, this complexity can be studied from different aspects; indeed, detailed analysis are under way on its splicing isoforms [ 46 , 47 ], its connection and regulation to miRNAs [ 48 , 49 , 50 , 51 ] as well as its stability and degradation [ 24 , 52 , 53 , 54 , 55 , 56 , 57 , 58 ]. Furthermore, in keeping with the progress in understanding p53 function, there is also a strong effort in investigating innovative therapeutic cues [ 59 , 60 , 61 , 62 , 63 ]. Of note, the other members of the family, p63 and p73, which were discovered only ten years ago, have an evident complex interplay with p53 itself [ 64 , 65 , 66 , 67 , 68 ].…”

Section: Discussionmentioning

confidence: 99%

Ultraconserved long non-coding RNA uc.63 in breast cancer

et al. 2016

Self Cite

View full text Add to dashboard Cite

Transcribed-ultraconserved regions (T-UCRs) are long non-coding RNAs (lncRNA) encoded by a subset of long ultraconserved stretches in the human genome. Recent studies revealed that the expression of several T-UCRs is altered in cancer and growing evidences underline the importance of T-UCRs in oncogenesis, offering also potential new strategies for diagnosis and prognosis. We found that overexpression of one specific T-UCRs named uc.63 is associated with bad outcome in luminal A subtype of breast cancer patients. uc.63 is localized in the third intron of exportin-1 gene (XPO1) and is transcribed in the same orientation of its host gene. Interestingly, silencing of uc.63 induces apoptosis in vitro. However, silencing of host gene XPO1 does not cause the same effect suggesting that the transcription of uc.63 is independent of XPO1. Our results reveal an important role of uc.63 in promoting breast cancer cells survival and offer the prospect to identify a signature associated with poor prognosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Ultraconserved long non-coding RNA uc.63 in breast cancer

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…In vitro experiments showed that SSRIs stimulated apoptosis and autophagy in glioma stem cells. Since the presence of cancer stem cells results in metastasis and invasion, along with resistance to chemotherapy, it is promising for the application of SSRIs as specific therapies targeting the serotonin system in cancer stem cells [ 44 ]. Furthermore, SSRIs might be a potential agent to treat the adverse effect of chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Use of Selective Serotonin Reuptake Inhibitors Is Associated with a Lower Risk of Colorectal Cancer among People with Family History

Zhang

Sundquist

et al. 2022

Cancers

View full text Add to dashboard Cite

Individuals with a family history of colorectal cancer (CRC) are at a high risk of developing CRC. Preclinical and population-based evidence suggests that selective serotonin reuptake inhibitors (SSRIs) might play a role in preventing CRC. We performed a nationwide cohort study to explore whether the use of SSRIs could reduce CRC risk among individuals with family history. We identified individuals aged 50 and above who had one or more first-degree relatives diagnosed with CRC. A total of 38,617 incident SSRI users were identified and matched with 115,851 non-users, on a ratio of 1:3. The Cox regression model was used to calculate hazard ratios (HRs) and 95% CI confidence intervals (CIs). We found a significant negative association between SSRI use and the risk of CRC (adjusted HR, 0.77; 95% CI, 0.70–0.85). Restricted cubic spline regression showed a non-linear dose–responded relationship between SSRI use and CRC risk. The association was stronger in rectal cancer than colon cancer (adjusted HR, 0.73 vs. 0.79), and more pronounced in advanced-stage CRC than early-stage CRC (adjusted HR, 0.73 vs. 0.80). This population-based cohort study suggests that the use of SSRIs is associated with a reduced risk of CRC among individuals with a family history of CRC.

show abstract

Antidepressants synergize with chemotherapy against cancer stem cells

Cited by 2 publications

References 7 publications

Ultraconserved long non-coding RNA uc.63 in breast cancer

Ultraconserved long non-coding RNA uc.63 in breast cancer

Use of Selective Serotonin Reuptake Inhibitors Is Associated with a Lower Risk of Colorectal Cancer among People with Family History

Contact Info

Product

Resources

About