Antidepressants for depression in adults with HIV infection

Abstract

Trusted evidence. Informed decisions. Better health.

Who is most likely to benefit from a positive psychological intervention? Moderator analyses from a randomized trial in people newly diagnosed with HIV

“…While antidepressant therapy in PLWH may improve depression, most trials have lacked rigor (Eshun-Wilson et al, 2018). Moreover, PLWH frequently report unwanted side effects of antidepressants, and how these medications affect HIV outcomes remains largely unknown (Eshun-Wilson et al, 2018). Our results suggest that, when antidepressant therapy is contraindicated/undesirable, IRISS provides another possibility for improving emotion regulation, particularly for PLWH who are older, racial/ethnic minorities, college graduates, and those with elevated depression or stress.…”

“…While antidepressant therapy in PLWH may improve depression, most trials have lacked rigor (Eshun-Wilson et al, 2018). Moreover, PLWH frequently report unwanted side effects of antidepressants, and how these medications affect HIV outcomes remains largely unknown (Eshun-Wilson et al, 2018).…”

Who is most likely to benefit from a positive psychological intervention? Moderator analyses from a randomized trial in people newly diagnosed with HIV

“…While antidepressant therapy in PLWH may improve depression, most trials have lacked rigor (Eshun-Wilson et al, 2018). Moreover, PLWH frequently report unwanted side effects of antidepressants, and how these medications affect HIV outcomes remains largely unknown (Eshun-Wilson et al, 2018). Our results suggest that, when antidepressant therapy is contraindicated/undesirable, IRISS provides another possibility for improving emotion regulation, particularly for PLWH who are older, racial/ethnic minorities, college graduates, and those with elevated depression or stress.…”

“…While antidepressant therapy in PLWH may improve depression, most trials have lacked rigor (Eshun-Wilson et al, 2018). Moreover, PLWH frequently report unwanted side effects of antidepressants, and how these medications affect HIV outcomes remains largely unknown (Eshun-Wilson et al, 2018).…”

Efficacy and Safety of Antidepressants in Patients With Comorbid Depression and Medical Diseases

“…Based on these descriptive data, we identified the largest systematic reviews within each medical disease. Data on primary and secondary outcome measures for these 73 systematic reviews are presented in eTable 7 in Supplement 2 for treatment of depression and in eTable 8 in Supplement 2 for prevention of depression.…”

Beck Depression Inventory (BDI-IA) adapted for HIV: Psychometric properties, sensitivity & specificity in depressive episodes, adjustment disorder & without symptomatology

“…We obtained construct validity, thereby replicating the psychometric analysis procedure of the original version, and updated it with the current criteria, using CFA (DiPrete, Pence, Grelotti, & Gaynes, 2018). This means that we can have a tool in Mexico for screening for depression symptoms in PLWH since several authors have highlighted the need for methods that have been validated in this population, which could be used on a massive scale and incorporated into decision-making (Eshun-Wilson et al, 2018;Perazzo et al, 2020).…”

Who is most likely to benefit from a positive psychological intervention? Moderator analyses from a randomized trial in people newly diagnosed with HIV

“…While antidepressant therapy in PLWH may improve depression, most trials have lacked rigor (Eshun-Wilson et al, 2018). Moreover, PLWH frequently report unwanted side effects of antidepressants, and how these medications affect HIV outcomes remains largely unknown (Eshun-Wilson et al, 2018). Our results suggest that, when antidepressant therapy is contraindicated/undesirable, IRISS provides another possibility for improving emotion regulation, particularly for PLWH who are older, racial/ethnic minorities, college graduates, and those with elevated depression or stress.…”

“…While antidepressant therapy in PLWH may improve depression, most trials have lacked rigor (Eshun-Wilson et al, 2018). Moreover, PLWH frequently report unwanted side effects of antidepressants, and how these medications affect HIV outcomes remains largely unknown (Eshun-Wilson et al, 2018).…”

Efficacy and Safety of Antidepressants in Patients With Comorbid Depression and Medical Diseases

“…Based on these descriptive data, we identified the largest systematic reviews within each medical disease. Data on primary and secondary outcome measures for these 73 systematic reviews are presented in eTable 7 in Supplement 2 for treatment of depression and in eTable 8 in Supplement 2 for prevention of depression.…”

Beck Depression Inventory (BDI-IA) adapted for HIV: Psychometric properties, sensitivity & specificity in depressive episodes, adjustment disorder & without symptomatology

“…We obtained construct validity, thereby replicating the psychometric analysis procedure of the original version, and updated it with the current criteria, using CFA (DiPrete, Pence, Grelotti, & Gaynes, 2018). This means that we can have a tool in Mexico for screening for depression symptoms in PLWH since several authors have highlighted the need for methods that have been validated in this population, which could be used on a massive scale and incorporated into decision-making (Eshun-Wilson et al, 2018;Perazzo et al, 2020).…”

Who is most likely to benefit from a positive psychological intervention? Moderator analyses from a randomized trial in people newly diagnosed with HIV

“…While antidepressant therapy in PLWH may improve depression, most trials have lacked rigor (Eshun-Wilson et al, 2018). Moreover, PLWH frequently report unwanted side effects of antidepressants, and how these medications affect HIV outcomes remains largely unknown (Eshun-Wilson et al, 2018). Our results suggest that, when antidepressant therapy is contraindicated/undesirable, IRISS provides another possibility for improving emotion regulation, particularly for PLWH who are older, racial/ethnic minorities, college graduates, and those with elevated depression or stress.…”

“…While antidepressant therapy in PLWH may improve depression, most trials have lacked rigor (Eshun-Wilson et al, 2018). Moreover, PLWH frequently report unwanted side effects of antidepressants, and how these medications affect HIV outcomes remains largely unknown (Eshun-Wilson et al, 2018).…”

Efficacy and Safety of Antidepressants in Patients With Comorbid Depression and Medical Diseases

“…Based on these descriptive data, we identified the largest systematic reviews within each medical disease. Data on primary and secondary outcome measures for these 73 systematic reviews are presented in eTable 7 in Supplement 2 for treatment of depression and in eTable 8 in Supplement 2 for prevention of depression.…”

Beck Depression Inventory (BDI-IA) adapted for HIV: Psychometric properties, sensitivity & specificity in depressive episodes, adjustment disorder & without symptomatology

“…We obtained construct validity, thereby replicating the psychometric analysis procedure of the original version, and updated it with the current criteria, using CFA (DiPrete, Pence, Grelotti, & Gaynes, 2018). This means that we can have a tool in Mexico for screening for depression symptoms in PLWH since several authors have highlighted the need for methods that have been validated in this population, which could be used on a massive scale and incorporated into decision-making (Eshun-Wilson et al, 2018;Perazzo et al, 2020).…”