Antidepressant-like effects of alnespirone (S 20499) in the learned helplessness test in rats

Antidepressant-like behavioral and neurochemical effects of the citrus-associated chemical apigenin

“…However, there was no clear dose-response trend observed in the CMS rats treated with the two doses of apigenin. Indeed, a U-shaped dose-response pattern induced by antidepressants has been always observed in some animal experiments (MacSweeney et al, 1998;Muñoz and Papp, 1999;Kulkarni and Dhir, 2007). Therefore, the dose-dependent relationship of apigenin in behavioral studies needs to be further investigated based on our findings.…”

Neonatal treatment with fluoxetine reduces depressive behavior induced by forced swim in adult rats

“…PALAVRAS-CHAVE: depressão, serotonina, inibidor de recaptação da 5-HT, neurogênese. Studies in animals and humans have demonstrated the role of serotonin (5-hidroxytryptamine, 5-HT) in psychiatric depressions 1 , through the use of pharmacological tools 2 . Experimental evidences of serotonin receptors involvement in the pathophysiology of depression and in the action mechanisms of antidepressant drugs, come from various biochemical, electrophysiological and behavioral approaches 3 .…”

Antidepressant-like effects of agomelatine (S 20098) in the learned helplessness model

“…First, the learned helplessness test is a well-accepted animal model of human depressive disorder (Sherman et al, 1982). Restoration of normal escape behavior can be achieved in this test by subchronic treatment (3-7 days) with a variety of antidepressants, including tricyclics and monoamine oxidase inhibitors (Martin et al, 1987;Millan et al, 1997;Takamori et al, 2001), 5-HT re-uptake inhibitor agents (Martin et al, 1990) and 5-HT 1A agonists (Giral et al, 1988;Mac Sweeney et al, 1998). Second, the use of the learned helplessness model in evaluating the efficacy of agomelatine is of particular interest as the disruption of body temperature, feeding and sleep circadian rhythms have also been observed in animals submitted to this kind of uncontrollable stress (Kant et al, 1991(Kant et al, , 1995, and this may mimic the disorganization of internal rhythms involved in the pathophysiology of depressive disorders (Wehr and Wirz-Justice, 1982).…”