Antidepressant-like effect of 5-O-methylvisammioside targeting SRC is accompanied by hippocampal neuroinflammation reduction in lipopolysaccharide-challenged mice
Wen-Qian Zhu,
Bing-Jin Li,
Ran-Ji Cui
Abstract:5-O-methylvisammioside (MeV), a phenolic compound found in the underground part (radix) Saposhnikovia divaricate (Turcz. ex Ledeb.) Schischk. (Apiaceae) in the early stage, has also been detected in the extract of Eranthis longistipitata(Ranunculaceae) in recent literature. In previous studies, it was discovered to have anti-inflammatory and neuroprotective activities. However, the potential mechanisms of MeV antidepressants remain unclear. In the present study, Network pharmacology was adopted to conduct drug… Show more
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