Purpose:To compare the effects of the antidepressant drugs duloxetine and amitriptyline on depressive behaviors in rats. Methods: Fifteen male Wistar rats were given systemic injections of duloxetine, amitriptyline or saline prior to a Forced Swimming Test (FST). Immobility and number of stops were measured. Data were analyzed by one-way ANOVA and Kruskall-Wallis. Results: Rats given injections of duloxetine displayed fewer stops than the amitriptyline and control group (p< 0.05). The control group a… Show more
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