Antidepressant Active Ingredients From Chinese Traditional Herb Panax Notoginseng: A Pharmacological Mechanism Review

Li, Yanwei; Guo, Qingwan; Huang, Junqing; Wang, Ziying

doi:10.3389/fphar.2022.922337

Cited by 5 publications

(2 citation statements)

References 90 publications

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“…Li et al also surveyed most recent 20 years of research on P . notoginseng for treating depression, which has been shown to have a therapeutic effect on depression [ 62 ].…”

Section: Potential Of P Notoginseng Relieve Post-c...mentioning

confidence: 99%

The potential of Panax notoginseng against COVID-19 infection

Zhang

et al. 2023

Journal of Ginseng Research

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“…Li et al also surveyed most recent 20 years of research on P . notoginseng for treating depression, which has been shown to have a therapeutic effect on depression [ 62 ].…”

Section: Potential Of P Notoginseng Relieve Post-c...mentioning

confidence: 99%

The potential of Panax notoginseng against COVID-19 infection

Zhang

et al. 2023

Journal of Ginseng Research

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“…Panax notoginseng (PN) is not only a Chinese medicine that is used to treat cardiovascular disease (CVD) but is also a dietary supplement. Previous studies have shown that PN exerts many physiological effects; PN is used to treat atherosclerosis [ 1 ], regulate blood sugar [ 2 ], inhibit cancer growth [ 3 ] and metastasis [ 4 , 5 ], protect kidneys [ 6 ], and treat depression [ 7 , 8 ]. Notably, previous studies on the role of PN in alleviating cardiovascular pathology showed that PN can reduce vascular endothelial disorders in C57BL/6 mice fed a high-fat diet by decreasing the phosphorylation of 5’AMP-activated protein kinase (AMPK), the expression of endothelial nitric oxide synthase (eNOS), endoplasmic reticulum stress, and oxidative stress [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Panax notoginseng Suppresses Bone Morphogenetic Protein-2 Expression in EA.hy926 Endothelial Cells by Inhibiting the Noncanonical NF-κB and Wnt/β-Catenin Signaling Pathways

Ping

Hsieh

Wang

et al. 2022

Plants

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Panax notoginseng (PN) exerts cardiovascular-disease-protective effects, but the effect of PN on reducing vascular calcification (VC) is unknown. Under the VC process, however, endothelial bone morphogenetic protein-2 (BMP-2) signals connect endothelial and smooth muscle cells. To investigate the effects of PN water extract (PNWE) on BMP-2 expression, human EA.hy926 endothelial cells were pretreated with PNWE for 48 h, and BMP-2 expression was then induced using warfarin/β-glycerophosphate (W/BGP) for another 24 h. The expression of BMP-2, the degrees of oxidative stress and inflammation, and the activation of noncanonical NF-κB and Wnt/β-catenin signaling were analyzed. The results showed that the BMP-2 levels in EA.hy926 cells were reduced in the groups treated with 10, 50, or 100 μg/mL PNWE combined with W/BGP. PNWE combined with W/BGP significantly reduced thiobarbituric-acid-reactive substrate and reactive oxygen species levels as well as prostaglandin E2, IL-1β, IL-6, and TNF-α. PNWE (10, 50, and 100 μg/mL) reduced the p52 levels and p52/p100 protein ratio. Wnt and β-catenin protein expression was decreased in the groups treated with PNWE combined with W/BGP. These results showed that PNWE reduced BMP-2 expression in EA.hy926 cells by inhibiting the noncanonical NF-κB and Wnt/β-catenin signaling pathways.

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Production of rare ginsenosides by biotransformation of Panax notoginseng saponins using Aspergillus fumigatus

Yang,

Lin,

et al. 2024

Bioresour. Bioprocess.

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Panax notoginseng saponins (PNS) are the main active components of Panax notoginseng. But after oral administration, they need to be converted into rare ginsenosides by human gut microbiota and gastric juice before they can be readily absorbed into the bloodstream and exert their effects. The sources of rare ginsenosides are extremely limited in P. notoginseng and other medical plants, which hinders their application in functional foods and drugs. Therefore, the production of rare ginsenosides by the transformation of PNS using Aspergillus fumigatus was studied in this research. During 50 days at 25 ℃ and 150 rpm, A. fumigatus transformed PNS to 14 products (1–14). They were isolated by varied chromatographic methods, such as silica gel column chromatography, Rp-C18 reversed phase column chromatography, semi-preparative HPLC, Sephadex LH-20 gel column chromatography, and elucidated on the basis of their 1H-NMR, 13C-NMR and ESIMS spectroscopic data. Then, the transformed products (1–14) were isolated and identified as Rk3, Rh4, 20 (R)-Rh1, 20 (S)-Protopanaxatriol, C-K, 20 (R)-Rg3, 20 (S)-Rg3, 20 (S)-Rg2, 20 (R)-R2, Rk1, Rg5, 20 (S)-R2, 20 (R)-Rg2, and 20 (S)-I, respectively. In addition, all transformed products (1–14) were tested for their antimicrobial activity. Among them, compounds 5 (C-K) and 7 [20 (S)-Rg3] showed moderate antimicrobial activities against Staphylococcus aureus and Candida albicans with MIC values of 6.25, 1.25 μg/mL and 1.25, 25 μg/mL, respectively. This study lays the foundation for production of rare ginsenosides. Graphical abstract

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Antidepressant Active Ingredients From Chinese Traditional Herb Panax Notoginseng: A Pharmacological Mechanism Review

Cited by 5 publications

References 90 publications

The potential of Panax notoginseng against COVID-19 infection

The potential of Panax notoginseng against COVID-19 infection

Panax notoginseng Suppresses Bone Morphogenetic Protein-2 Expression in EA.hy926 Endothelial Cells by Inhibiting the Noncanonical NF-κB and Wnt/β-Catenin Signaling Pathways

Production of rare ginsenosides by biotransformation of Panax notoginseng saponins using Aspergillus fumigatus

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