Anticoagulants and Antiplatelet Agents in Pregnancy

Monitoring of anticoagulation in thrombotic antiphospholipid syndrome

“…14 Figure 1 summarizes coagulation mechanisms and targets for actions of different anticoagulants. 15 Anticoagulation, in combination with corticosteroids, plasma exchange, and/or intravenous immunoglobulin (IVIG), is standard treatment for CAPS. 3,4,16 Non-criteria APS manifestations, which include livedo reticularis, thrombocytopenia, hemolytic anemia, cardiac valve disease, nephropathy, skin ulcers, and cognitive dysfunction, 1 are generally anticoagulant-refractory and require consideration of further therapeutic approaches.…”

“…Abbreviations: AT, antithrombin; LMWH, low molecular weight heparin; PC, protein C; PS, protein S; UFH, unfractionated heparin. (Adapted from Drebes et al 15 )…”

“…LMWH, in combination with low dose aspirin (LDA), is standard treatment for thrombotic APS during pregnancy 14 . Figure 1 summarizes coagulation mechanisms and targets for actions of different anticoagulants 15 . Anticoagulation, in combination with corticosteroids, plasma exchange, and/or intravenous immunoglobulin (IVIG), is standard treatment for CAPS 3,4,16 .…”