Anticipating social incentives recruits alpha-beta oscillations in the human substantia nigra and invigorates behavior across the life span

Sobczak, Alexandra; Repplinger, Stefan; Bauch, Eva M.; Brueggemann, Norbert; Lohse, C.; Hinrichs, Hermann; Buentjen, Lars; Voges, J.; Zaehle, Tino; Bunzeck, Nico

doi:10.1016/j.neuroimage.2021.118696

Cited by 4 publications

(5 citation statements)

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“…The BF signals valence across a variety of stimuli, including food [36], liquids, air-puffs, and electrical shocks in animals [37][38][39][40] but also social incentives in humans [4,36]. Specifically, cholinergic neurons in the NBM and DB in mice respond to reward delivery [38], and neurons in the SI and MS / DB in primates respond to reward predicting stimuli [37,39].…”

Section: Empirical Evidence For a Role Of The Bf In Motivation And So...mentioning

confidence: 99%

“…Specifically, cholinergic neurons in the NBM and DB in mice respond to reward delivery [38], and neurons in the SI and MS / DB in primates respond to reward predicting stimuli [37,39]. In humans, affiliative rewards increased activity in the septohypothalamic area [36] and predictors of positive social feedback increased functional coupling between the NBM and interconnected ventral SN [4]. The anticipation and delivery of punishments, on the other hand, elicit responses in the SI and MS/DB as shown in monkeys and mice [37,39,40].…”

Section: Empirical Evidence For a Role Of The Bf In Motivation And So...mentioning

confidence: 99%

“…The suppression of cholinergic projections from the BF to the mPFC during the anticipation of a negative outcome impairs the learning of aversive associations with a negative cue in mice [42]. In humans, anticipating social punishment (avoidance) was associated with increased BOLD activity in septal nuclei [17] and increased functional connectivity between the MS/DB and lateral SN [4]. Another study found that functional connectivity patterns of the NBM and septum with a wider social information processing network (including the VTA, NAcc, amygdala, insula, and orbitofrontal cortex) depends on the valence of social interactions [43].…”

Section: Empirical Evidence For a Role Of The Bf In Motivation And So...mentioning

confidence: 99%

“…Furthermore, the cholinergic projections of the NBM and PFC are involved in sustained attention [74,75]. Along these lines, functional coupling between the NAcc and NBM during social feedback anticipation (irrespective of the valence of the feedback) in humans [4] may also implicate a mechanism that guides attention towards relevant information.…”

Section: A More General Perspective On "Cortical and Subcortical Soci...mentioning

confidence: 99%

“…The basal forebrain (BF) is involved in attentional control, learning and memory, and, as shown in more recent studies, motivational processing [1][2][3][4]. To further clarify the latter aspect, this review aims to characterize the BF's role in social cognition with a focus on motivational aspects that shape social behaviors.…”

Section: Introductionmentioning

confidence: 99%

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The Basal Forebrain Serves Social Information Processing

Sobczak,

Bunzeck

2023

Preprint

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Empirical evidence suggests a critical, but little understood, contribution of the cholinergic basal forebrain (BF) to motivational aspects of social cognition. Therefore, we review the current literature on reward and punishment processing in the BF, including social information, in both animals and more recently human imaging studies. This also includes possible interactions with other subcortical structures, especially the ventral striatum and dopaminergic midbrain. Importantly, the BF typically degenerates during healthy and pathological aging, including Parkinson’s disease with dementia, which helps to further understand its role in social information processing. Finally, we suggest a model of cortical and subcortical social information processing (CASSI) bringing together BF contributions in concert with the dopaminergic midbrain and prefrontal cortex to promote social cognition.

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Section: Empirical Evidence For a Role Of The Bf In Motivation And So...mentioning

confidence: 99%

Section: Empirical Evidence For a Role Of The Bf In Motivation And So...mentioning

confidence: 99%

Section: Empirical Evidence For a Role Of The Bf In Motivation And So...mentioning

confidence: 99%

Section: A More General Perspective On "Cortical and Subcortical Soci...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Basal Forebrain Serves Social Information Processing

Sobczak,

Bunzeck

2023

Preprint

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Anticipating social feedback involves basal forebrain and mesolimbic functional connectivity

2023

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Effects of positive and negative social feedback on motivation, evaluative learning, and socio-emotional processing

Sobczak,

Bunzeck

2023

npj Sci. Learn.

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Social rewards and punishments are strong motivators. Since experimental work has focused on young adults using simplistic feedback, the effects of more naturalistic stimuli on motivation, evaluative learning, and socio-emotional processing with advanced age remain unclear. Therefore, we compared the effects of static (photos) vs dynamic (videos) social feedback in a social incentive delay (SID) task in young (18–35 years) and older adults (50–84 years) with neutral, positive, and negative feedback, on response times (RTs), and assessed the emotional valence of feedback cues and feedback videos. We found that anticipating positive and negative social feedback accelerated RTs regardless of age and without additional effects of video feedback. Furthermore, the results suggest a valence transfer from positive feedback videos to predictive cues in both groups (i.e., evaluative learning). Finally, older adults reported less pronounced negative affect for negative feedback videos, indicating age differences in socio-emotional processing. As such, our findings foster our understanding of the underlying cognitive and emotional aspects involved in the processing of social rewards and punishments.

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Anticipating social incentives recruits alpha-beta oscillations in the human substantia nigra and invigorates behavior across the life span

Cited by 4 publications

References 80 publications

The Basal Forebrain Serves Social Information Processing

The Basal Forebrain Serves Social Information Processing

Anticipating social feedback involves basal forebrain and mesolimbic functional connectivity

Effects of positive and negative social feedback on motivation, evaluative learning, and socio-emotional processing

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