Anticholinergics for prolonged non-specific cough in children

Abstract

There is currently no evidence to support the use of inhaled anti-cholinergics for symptomatic control of non-specific cough in children. Further research examining the effects of this intervention is needed.

Analysis of the Literature on Chronic Cough in Children

“…In regard to these latter Cochrane SR references [29-33], our research failed to discover any subsequent noteworthy trials. There are two SRs regarding the use of inhaled corticosteroids [39, 40].…”

“…One of these 15 SRs examined the management algorithms that were mentioned earlier in this review [26]. Five SRs [29-33] did not include any pertinent work, nor did our research reveal more recent pertinent trials. These include trials with chromones, anticholinergic agents, obstructive sleep apnea syndrome therapies, modification of indoor environments, and honey or cough drop usage.…”

Analysis of the Literature on Chronic Cough in Children

“…In regard to these latter Cochrane SR references [29-33], our research failed to discover any subsequent noteworthy trials. There are two SRs regarding the use of inhaled corticosteroids [39, 40].…”

“…One of these 15 SRs examined the management algorithms that were mentioned earlier in this review [26]. Five SRs [29-33] did not include any pertinent work, nor did our research reveal more recent pertinent trials. These include trials with chromones, anticholinergic agents, obstructive sleep apnea syndrome therapies, modification of indoor environments, and honey or cough drop usage.…”

Histamine and H1-antihistamines: Celebrating a century of progress

“…[76][77][78][79][80][81][82][83][84][85][86][87][88][89][90][91] Atopic dermatitis. Histamine acts as a pruritogen through H 4 -receptors in patients with atopic dermatitis, and other mediators, including IL-31 and other cytokines, play an important role.…”

“…H 1 -antihistamines are used to treat symptoms of upper respiratory tract infections, acute otitis media, otitis media with effusion, sinusitis, nasal polyps, nonspecific cough, and nonallergic, nonspecific itching; however, their efficacy and safety have not been confirmed in high-quality randomized controlled trials in patients with any of these disorders. 1,18,57,[80][81][82][83][84][85] Central nervous system and vestibular disorders…”

Pediatric cough: what the otolaryngologist needs to know

“…Several Cochrane Database Reviews have concluded that there is no evidence to support the use of inhaled anticholinergics in chronic cough [40,41]. Use of b 2 -agonists for acute bronchitis or nonspecific chronic cough is not effective [42].…”

Analysis of the Literature on Chronic Cough in Children

“…In regard to these latter Cochrane SR references [29-33], our research failed to discover any subsequent noteworthy trials. There are two SRs regarding the use of inhaled corticosteroids [39, 40].…”

“…One of these 15 SRs examined the management algorithms that were mentioned earlier in this review [26]. Five SRs [29-33] did not include any pertinent work, nor did our research reveal more recent pertinent trials. These include trials with chromones, anticholinergic agents, obstructive sleep apnea syndrome therapies, modification of indoor environments, and honey or cough drop usage.…”

Histamine and H1-antihistamines: Celebrating a century of progress

“…[76][77][78][79][80][81][82][83][84][85][86][87][88][89][90][91] Atopic dermatitis. Histamine acts as a pruritogen through H 4 -receptors in patients with atopic dermatitis, and other mediators, including IL-31 and other cytokines, play an important role.…”

“…H 1 -antihistamines are used to treat symptoms of upper respiratory tract infections, acute otitis media, otitis media with effusion, sinusitis, nasal polyps, nonspecific cough, and nonallergic, nonspecific itching; however, their efficacy and safety have not been confirmed in high-quality randomized controlled trials in patients with any of these disorders. 1,18,57,[80][81][82][83][84][85] Central nervous system and vestibular disorders…”

Pediatric cough: what the otolaryngologist needs to know

“…Several Cochrane Database Reviews have concluded that there is no evidence to support the use of inhaled anticholinergics in chronic cough [40,41]. Use of b 2 -agonists for acute bronchitis or nonspecific chronic cough is not effective [42].…”

Analysis of the Literature on Chronic Cough in Children

“…In regard to these latter Cochrane SR references [29-33], our research failed to discover any subsequent noteworthy trials. There are two SRs regarding the use of inhaled corticosteroids [39, 40].…”

“…One of these 15 SRs examined the management algorithms that were mentioned earlier in this review [26]. Five SRs [29-33] did not include any pertinent work, nor did our research reveal more recent pertinent trials. These include trials with chromones, anticholinergic agents, obstructive sleep apnea syndrome therapies, modification of indoor environments, and honey or cough drop usage.…”

Histamine and H1-antihistamines: Celebrating a century of progress

“…[76][77][78][79][80][81][82][83][84][85][86][87][88][89][90][91] Atopic dermatitis. Histamine acts as a pruritogen through H 4 -receptors in patients with atopic dermatitis, and other mediators, including IL-31 and other cytokines, play an important role.…”

“…H 1 -antihistamines are used to treat symptoms of upper respiratory tract infections, acute otitis media, otitis media with effusion, sinusitis, nasal polyps, nonspecific cough, and nonallergic, nonspecific itching; however, their efficacy and safety have not been confirmed in high-quality randomized controlled trials in patients with any of these disorders. 1,18,57,[80][81][82][83][84][85] Central nervous system and vestibular disorders…”

Pediatric cough: what the otolaryngologist needs to know

“…Several Cochrane Database Reviews have concluded that there is no evidence to support the use of inhaled anticholinergics in chronic cough [40,41]. Use of b 2 -agonists for acute bronchitis or nonspecific chronic cough is not effective [42].…”