Anticholinergics Do Not Improve Cure Rate of Alarm Treatment of Monosymptomatic Nocturnal Enuresis

The biofeedback treatment for non‐monosymptomatic enuresis nocturna

“…28 The underlying mechanism of EAT is reported to be the inhibition of the micturition reflex in the central nervous system and the increase of the nocturnal and daytime bladder capacity. 22 Because of the high discontinuation of EAT and the related symptoms that need to be solved along with enuresis, we have been using biofeedback therapy for NMSEN in children from 2005 to present. It has good tolerability and demonstrates efficacy (64%) in children with enuresis and LUTS.…”

“…Hoeck et al reported that holding exercises combined with anticholinergic (oxybutynin) rather than an anticholinergic alone could increase the functional bladder capacity in children with NMSEN but they reported only a 7% cure rate. Yucel et al reported a 33% cure rate in patients with NMSEN using only anticholinergics, with an effective functional bladder capacity increase (117 vs. 171 ml).…”

“…However, it has a high discontinuation rate because it disrupts the sleep of patients and parents, success is not immediate and it takes at least 6 or 8 weeks . The underlying mechanism of EAT is reported to be the inhibition of the micturition reflex in the central nervous system and the increase of the nocturnal and daytime bladder capacity …”

Brazilian consensus in enuresis–recomendations for clinical practice

“…Treatment with alarm is better than oxybutynin alone and the addition of oxybutynin to the alarm does not improve the success rate in the initial treatment. This association is only indicated in refractory cases (43). Alarm was shown to be better than imipramine in improving the number of dry nights (44).…”