Anticardiolipin Antibodies and Recurrent Coronary Events

Bili, Androniki; Moss, Arthur J.; Francis, Charles W.; Zaręba, Wojciech; Watelet, Luc F. Miller; Sanz, Igñacio

doi:10.1161/01.cir.102.11.1258

Cited by 67 publications

(25 citation statements)

References 42 publications

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“…Zuckerman, et al 4) reported that the rates of thromboembolic events and myocardial reinfarction in patients with acute MI were significantly higher in aCL-positive patients than in the aCL negative group. The largest study on this issue was recently reported by Bili, et al 29) who studied 1150 AMI patients. They suggested that elevated aCL-IgG and low aCL-IgM antibodies were independent risk factors for recurrent cardiovascular events.…”

Section: Discussionmentioning

confidence: 99%

Association Between Anticardiolipin Antibodies and Recurrent Cardiac Events in Patients With Acute Coronary Syndrome

et al. 2005

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SUMMARYTo determine whether the presence of anticardiolipin (aCL) antibodies in patients with acute coronary syndome is predictive of recurrent cardiac events in hospital stay and follow-up.The study population consisted of 80 patients with acute coronary syndrome. IgM and IgG aCL levels were determined before hospital discharge. We divided the patients into those with an aCL IgG ≥ 40 IgG phospholipid units (group I, n = 30) and those with an aCL IgG < 40 IgG phospholipid units (group II, n = 50). All patients underwent coronary angiography. Follow-up coronary angiography was performed 12 months after percutaneous coronary intervention (PCI). Infectious and autoimmune diseases were exclusion criteria. Patients were observed to determine overall mortality, reinfarction, and restenosis.There were no differences between the groups with respect to the prevalence of hypertension, diabetes mellitus, and cigarette smoking, sex, or ejection fraction. The prevalence of left ventricular thrombus was similar between the groups (group I: 16% versus group II: 16.7%, P > 0.05). Although the presence of left atrial thrombus was much more frequent in cardiolipin positive patients (13% versus 4%, respectively), the difference was not statistically significant (P = 0.19). Restenosis was observed in 40% of the cardiolipin positive patients and 14% of the cardiolipin negative patients (P < 0.01). There was no significant association between reinfarction and anticardiolipin positivity during followup (26% versus 10%, P > 0.05). In group I patients, in-hospital mortality was somewhat more frequent compared to group II patients (4% versus 10%), but the difference was not statistically significant (P = 0.27). One year mortality was similar between the groups.These results suggest that 1) restenosis occurs more frequently in anticardiolipin positive patients and 2) no association is evident between positive aCL and mortality, reinfarction, and intracardiac thrombus. (Int Heart J 2005; 46: 631-638)

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Section: Discussionmentioning

confidence: 99%

Association Between Anticardiolipin Antibodies and Recurrent Cardiac Events in Patients With Acute Coronary Syndrome

et al. 2005

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“…The prevalence of anticardiolipin antibodies in the general population is reported to be between 1% and 9% [7,8]. Anticardiolipin antibodies were shown to be an independent risk factor for MI and recurrent events [9,10]. In the present study, we evaluated the yield of thrombophilia screening among young patients with MI and examined the relationship between the presence of thrombophilia and patients' traditional risk factor profile.…”

Section: Introductionmentioning

confidence: 95%

High prevalence of thrombophilia among young patients with myocardial infarction and few conventional risk factors

Segev¹,

Ellis²,

Segev³

et al. 2005

International Journal of Cardiology

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“…In addition, some authors 3,10 have found that aPL antibodies after MI are a risk factor for recurrent events, although these results have not been verified by others 11,12 . In addition, anticardiolipin antibodies in healthy men have been shown to confer a twofold increased relative risk for MI 2 .…”

Section: Discussionmentioning

confidence: 90%

Primary Antiphospholipid syndrome presenting with acute ST elevated MI with normal coronaries

et al. 2017

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Myocardial infarction (MI) under the age of 40 years accounts for around 3% of cases of coronary artery disease. Coronary artery atherosclerosis is less commonly the underlying aetiology in this age group and more comprehensive investigation of the cause is required. Antiphospholipid syndrome is a rare cause for MI which can be found younger age group. Here,We report a22 years young patients with MI who had normal coronary arteries on coronary angiogram that proved to have primary APS.University Heart Journal Vol. 12, No. 1, January 2016; 49-50

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Anticardiolipin Antibodies and Recurrent Coronary Events

Cited by 67 publications

References 42 publications

Association Between Anticardiolipin Antibodies and Recurrent Cardiac Events in Patients With Acute Coronary Syndrome

Association Between Anticardiolipin Antibodies and Recurrent Cardiac Events in Patients With Acute Coronary Syndrome

High prevalence of thrombophilia among young patients with myocardial infarction and few conventional risk factors

Primary Antiphospholipid syndrome presenting with acute ST elevated MI with normal coronaries

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