Anticancer and antiviral activities of Youngia japonica (L.) DC (Asteraceae, Compositae)

Ooi, Linda S. M.; Wang, Hua; Luk, Choi-Wan; Ooi, Vincent E.C.

doi:10.1016/j.jep.2004.05.004

Cited by 44 publications

(32 citation statements)

References 12 publications

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“…Fractions with similar R f values were combined and concentrated to afford 11 fractions. Fractions 10 and 11 are the most effective antiviral agents as reported previously (Ooi et al, 2004).…”

Section: Isolation Of Pure Compounds From the Ethanol Extracts Of Yousupporting

confidence: 63%

“…Further separation of this extract by column chromatography on silica gel-60 produced 11 fractions. Fractions 10 and 11 were the most effective antiviral agents as reported previously (Ooi et al, 2004). Fraction 10 was further fractionated to yield nine subfractions (B 1 -B 9 ).…”

Section: Resultsmentioning

confidence: 65%

“…In the previous paper (Ooi et al, 2004) we have found that the ethanol extract of a biannual common weed, Youngia japonica (also known as Oriental or Asiatic hawk's beard) (Asteraceae, Compositae) exhibited antiviral activity against respiratory syncytial virus (RSV) cultured in HEp-2 cells with 50% inhibitory concentration (IC 50 ) in the range of 3.0-6.0 g/ml, comparable to the current clinically used antiviral drug, ribavirin. The selective index (SI), i.e.…”

Section: Introductionmentioning

confidence: 99%

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Antiviral activities of purified compounds from Youngia japonica (L.) DC (Asteraceae, Compositae)

Ooi

Wang

et al. 2006

Journal of Ethnopharmacology

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Section: Isolation Of Pure Compounds From the Ethanol Extracts Of Yousupporting

confidence: 63%

Section: Resultsmentioning

confidence: 65%

Section: Introductionmentioning

confidence: 99%

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Antiviral activities of purified compounds from Youngia japonica (L.) DC (Asteraceae, Compositae)

Ooi

Wang

et al. 2006

Journal of Ethnopharmacology

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“…The findings of this study suggest that there may be cytotoxic compounds in Hibiscus rosa sinensis extract that can induce the cytotoxic action against cancer cells and initiate antiproliferation effect leading to cancer cell death [10]. Cytotoxic assays are an important approach for drug discovery from natural products.…”

Section: Discussionmentioning

confidence: 90%

Cytotoxic Activity of the Leaf and Stem Extracts of <i>Hibiscus rosa sinensis</i> (Malvaceae) against Leukaemic Cell Line (K-562)

Arullappan¹,

Muhamad²,

Zakaria³

2013

Trop. J. Pharm Res

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Purpose: To evaluate the cytotoxic activity of Hibiscus rosa sinensis against K-562 cancer cell line. Methods: The crude petroleum ether, ethyl acetate and methanol extracts of the leaf and stem of Hibiscus rosa sinensis were prepared using cold extraction method. The in vitro cytotoxic activity of the extracts (20 -100 µg/ml) was evaluated on leukaemic cancer cell line (K-562) and Mardin-Darby kidney cell line (MDBK) (control) using 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) and 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assays, followed by morphological detection with Hoeschst staining. Results: The methanol leaf extracts showed higher activity (IC50 value: 30.9 ± 1.1 µg/ml) against K-562 cells than petroleum ether and ethyl acetate extracts which exhibited IC50 of 87.6 ± 0.91 and 57.6 ± 0.61 µg/ml (p < 0.05), respectively. Meanwhile, stem extracts from methanol showed IC50 of 79.80 µg/ml against K-562. MDBK cells (positive control) showed IC50 > 100 µg/ml for all the extracts. On treating K-562 cells with methanol leaf extract (30 µg/ml), the former were observed to undergo apoptosis with nuclear segmentation after 24 h incubation. The methanol leaf extract produced cell death on K-562 cells by apoptosis. Conclusion: Hibiscus rosa sinensis extracts possess potentials as effective cytotoxic agents against K-562 cells.

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“…한편, 고들빼기 김치를 소재로 한 연구들 (Kang et al, 1983;Hwang et al, 1995a & b;Shin, 1996;Kim & Lee, 2008)이 있고, 김치 숙성 중 클로로필 및 유도체에 관한 연구 (Kim et al, 1998), 고들빼기의 채취 시기와 침지방법별 발효특성에 관한 연구 (Shin, 1996), Hwang et al (1995b) (Park, 1977)와 flavonoid 물질인 luteolin 등 (Young et al, 1992b)을, 분획물로부터 triterpene계통의 물질 (Shin, 1993) 을 각각 분리한 바 있다. Ma et al(1998)은 고들빼기 전초 로부터 항암성이 있는 것으로 보고 (Jang et al, 2000;Ooi et al, 2004)된 두 가지 guaianolide sesquiterpene lactone인 8-desoxyartelin[3-hydroxy-1(10), 3-guaiadiene-12,6-olide-2-one]…”

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Phenolics Level and Antioxidant Activity of Methanol Extracts from Different Plant Parts in Youngia sonchifolia

천상욱¹,

강종구²

2013

Korean Journal of Crop Science

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Proximate composition, total phenolics and total flavonoids level, DPPH radical scavenging activity, and cytotoxicity were determined in the methanol extracts of different plant parts of Youngia sonchifolia at reproductive growth stage. Crude protein and crude fat were present as the highest amount in flowers, and crude fiber in the stems and roots. The highest content of phenolics [mg ferulic acid equivalents (FAE) kg -1 dry weight (DW)] was found in flowers (highest) and followed by leaves, stems and roots (lowest). Flavonoids [mg rutin equivalents kg -1 DW] level, however, showed the highest in leaf extracts and lowest in root extracts. The antioxidant potential of the methanol extracts from the plants dose-dependently increased DPPH (1,1-diphenyl-2-picrylhydrazyl) free radical scavenging activity (%). DPPH radical scavenging activity were highest in root extracts (IC50 = 1,135.6 mg kg -1 ) and followed by leaf, stem and flower extracts. By way of MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay, methanol extracts of roots showed the highest anticancer activity on human cancer cell line Calu-6 for human pulmonary carcinoma (IC 50 = 196.3 mg kg -1 ) and HCT-116 for human colon carcinoma (IC50=623.6 mg kg -1 ).

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Anticancer and antiviral activities of Youngia japonica (L.) DC (Asteraceae, Compositae)

Cited by 44 publications

References 12 publications

Antiviral activities of purified compounds from Youngia japonica (L.) DC (Asteraceae, Compositae)

Antiviral activities of purified compounds from Youngia japonica (L.) DC (Asteraceae, Compositae)

Cytotoxic Activity of the Leaf and Stem Extracts of <i>Hibiscus rosa sinensis</i> (Malvaceae) against Leukaemic Cell Line (K-562)

Phenolics Level and Antioxidant Activity of Methanol Extracts from Different Plant Parts in Youngia sonchifolia

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