Anticancer and antimicrobial activity of mangrove derived fungi Hypocrea lixii VB1

Bhimba, B. Valentin; Franco, Don A.; Mathew, Jibi Merin; Jose, Geena Mary; Joel, Elsa Lycias; Thangaraj, M.

doi:10.1016/s1875-5364(12)60017-x

Cited by 32 publications

(26 citation statements)

References 9 publications

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“…A. marina has been used as a traditional medicine for the treatment of skin diseases, rheumatism, ulcers, and smallpox. In vitro antimalarial, antibacterial, analgesic, and cytotoxic activities of A. marina have been reported [15]. Hence, A. marina is considered a valuable source of chemical constituents with medicinal potential.…”

Section: Introductionmentioning

confidence: 99%

Polyphenol-rich Avicennia marina leaf extracts induce apoptosis in human breast and liver cancer cells and in a nude mouse xenograft model

Huang

et al. 2016

Oncotarget

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Avicennia marina is the most abundant and common mangrove species and has been used as a traditional medicine for skin diseases, rheumatism, ulcers, and smallpox. However, its anticancer activities and polyphenol contents remain poorly characterized. Thus, here we investigated anticancer activities of secondary A. marina metabolites that were purified by sequential soxhlet extraction in water, ethanol, methanol, and ethyl acetate (EtOAc). Experiments were performed in three human breast cancer cell lines (AU565, MDA-MB-231, and BT483), two human liver cancer cell lines (HepG2 and Huh7), and one normal cell line (NIH3T3). The chemotherapeutic potential of A. marina extracts was evaluated in a xenograft mouse model. The present data show that EtOAc extracts of A. marina leaves have the highest phenolic and flavonoid contents and anticancer activities and, following column chromatography, the EtOAc fractions F2-5, F3-2-9, and F3-2-10 showed higher cytotoxic effects than the other fractions. 1H-NMR and 13C-NMR profiles indicated that the F3-2-10 fraction contained avicennones D and E. EtOAc extracts of A. marina leaves also suppressed xenograft MDA-MB-231 tumor growth in nude mice, suggesting that EtOAc extracts of A. marina leaves may provide a useful treatment for breast cancer.

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Section: Introductionmentioning

confidence: 99%

Polyphenol-rich Avicennia marina leaf extracts induce apoptosis in human breast and liver cancer cells and in a nude mouse xenograft model

Huang

et al. 2016

Oncotarget

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“…Mangrove plants, distributed in tropical and subtropical intertidal forest wetlands, are reported as biodiverse ‘hotspots’ that harbor a variety of endophytic fungi, which can potentially be prolific sources of structurally unique and biologically active secondary metabolites . Some of these secondary metabolites have shown various forms of biological activities such as antibacterial, cytotoxic, anti‐inflammatory, antioxidant, and anticancer . Therefore, in recent years, more attention have been led to the discovery of promising clinical targets from these endophytes.…”

Section: Introductionmentioning

confidence: 99%

Chaetochromones A – C, Three New Polyketides from Mangrove Plant Derived Endophytic Fungus Phomopsis sp. SCSIO 41006

Zhang

Lin

et al. 2017

Chemistry & Biodiversity

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“…H. virens has generally been found earlier from soil, decaying wood, on other fungi (such as basidiomycetes) and as opportunistic plant symbionts (Herman et al, 2004;Druzhinina et al, 2011). According to some previous reports H. virens and H. lixii have been isolated from several mangrove plants, Rhizophora apiculata, R. mucronata, Avicenna officialis and A. marina (Liu et al, 2011;Bhimba et al, 2012). However, to the best of our knowledge this is the first isolation of an endophytic H. virens from the plant P. serratifolia.…”

Section: Discussionmentioning

confidence: 98%

Antimicrobial constituents of Hypocrea virens, an endophyte of the mangrove-associate plant Premna serratifolia L.

Ratnaweera¹,

Silva²,

Wijesundera³

et al. 2016

J. Natn. Sci. Foundation Sri Lanka

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Emergence of multidrug-resistant pathogenic microorganisms has prompted a worldwide search for new antibiotics from various sources. Endophytic fungi from unique habitats are considered as potential sources of novel bioactive compounds. Sri Lankan mangrove ecosystem is such a distinctive and unexploited resource for the discovery of structurally diverse and biologically active metabolites including antimicrobials. Nine endophytic fungi were isolated from the leaves and twigs of Premna serratifolia L. from a mangrove habitat in the Negombo lagoon and the antimicrobial activities of their laboratory cultures were evaluated. The most promising antimicrobial activity was exhibited by the endophytic fungus Hypocrea virens. Bioassay guided fractionation of the organic extract of this fungus led to the isolation of two known metabolites; the antimicrobial epidithiodioxopiperazine, gliotoxin (1), and the closely related but less active bisdethiobis(methylthio)gliotxin (2). The chemical structures of the two compounds were determined by spectroscopy and confirmed by comparison of mass and nuclear magnetic resonance (NMR) spectral data with the reported values for these molecules. The minimum inhibitory concentration (MIC) values obtained for gliotoxin (1) in the current study are 0.13 µg mL -1 for Bacillus subtilis, 16 µg mL -1 for Staphylococcus aureus, 32 µg mL -1 for Methicillin Resistant Staphylococcus aureus (MRSA) and Escherichia coli, 64 µg mL -1 for Pseudomonas aeruginosa and Candida albicans fungus. This is the first study to report the isolation of endophytic fungi from P. serratifolia and their antimicrobial activities.

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Anticancer and antimicrobial activity of mangrove derived fungi Hypocrea lixii VB1

Cited by 32 publications

References 9 publications

Polyphenol-rich Avicennia marina leaf extracts induce apoptosis in human breast and liver cancer cells and in a nude mouse xenograft model

Polyphenol-rich Avicennia marina leaf extracts induce apoptosis in human breast and liver cancer cells and in a nude mouse xenograft model

Chaetochromones A – C, Three New Polyketides from Mangrove Plant Derived Endophytic Fungus Phomopsis sp. SCSIO 41006

Antimicrobial constituents of Hypocrea virens, an endophyte of the mangrove-associate plant Premna serratifolia L.

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