Anticancer activity of “Trigno M”, extract of Prunus spinosa drupes, against in vitro 3D and in vivo colon cancer models

Condello, Maria; Pellegrini, Evelin; Spugnini, Enrico P.; Baldi, Alfonso; Amadio, Bruno; Vincenzi, Bruno; Occhionero, Giovanni; Delfine, Sebastiano; Mastrodonato, Franco; Meschini, Stefania

doi:10.1016/j.biopha.2019.109281

Cited by 26 publications

(23 citation statements)

References 28 publications

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“…Besides, the daily administration of anthocyanin-rich extracts from black rice (100 mg/kg, during 28 weeks) in mice xenografted with human tumour models showed the ability to reduce breast cancer growth, causing reductions around 41% [ 185 ], mainly due to their ability to inhibit growth factor receptor 2, a gene overexpressed in this type of cancer [ 186 ]. Blackthorn fruits at 0.2 mg daily (5 days a week, for one month) already showed potential to slow down tumour growth xenografts in immunodeficient mice injected with human colon HCT116 cancer cells [ 187 ]. Anthocyanins from black rice already showed potential to increase immune responses in murine leukaemia cells, at concentrations higher than 50 mg/kg over 3 weeks of treatment, promoting CD3 (T cell), CD19 (B cell), CD11b (monocyte), and macrophage phagocytosis, and decreasing the NK cell activity when compared to the untreated control group [ 188 ].…”

Section: Putative Health Benefitsmentioning

confidence: 99%

Dietary Effects of Anthocyanins in Human Health: A Comprehensive Review

et al. 2021

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In recent years, the consumption of natural-based foods, including beans, fruits, legumes, nuts, oils, vegetables, spices, and whole grains, has been encouraged. This fact is essentially due to their content in bioactive phytochemicals, with the phenolic compounds standing out. Among them, anthocyanins have been a target of many studies due to the presence of catechol, pyrogallol, and methoxy groups in their chemical structure, which confer notable scavenging, anti-apoptotic, and anti-inflammatory activities, being already recommended as supplementation to mitigate or even attenuate certain disorders, such as diabetes, cancer, and cardiovascular and neurological pathologies. The most well-known anthocyanins are cyanidin 3-O-glucoside and cyanidin 3-O-rutinoside. They are widespread in nature, being present in considerable amounts in red fruits and red vegetables. Overall, the present review intends to discuss the most recent findings on the potential health benefits from the daily intake of anthocyanin-rich foods, as well as their possible pharmacological mechanisms of action. However, before that, some emphasis regarding their chemical structure, dietary sources, and bioavailability was done.

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Section: Putative Health Benefitsmentioning

confidence: 99%

Dietary Effects of Anthocyanins in Human Health: A Comprehensive Review

et al. 2021

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“…Other berries like red raspberry and strawberry extract, lingonberry, elderberry, and black currant showed antitumor effects in CRC cell lines by inhibiting cell growth and promoting cell apoptosis [33,52]. The anthocyanin extract from flowering plant berries such as Prunus spinosa drupes (blackthorn) could inhibit the growth and colony formation, promote apoptosis in HCT-116 cells, and reduce tumor growth in xenograft mice [53]. Pistacia atlantica sub kurdica HT 29 cell Inhibited cell growth; arrested S phase [72] Chinese eggplant HT 29 cell Antioxidant, protected cell from DNA damage [71] Apple Rat…”

Section: Other Berriesmentioning

confidence: 99%

Anthocyanins in Colorectal Cancer Prevention Review

Shi

Chen

2021

Antioxidants

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Colorectal cancer (CRC) is still a big health burden worldwide. Nutrition and dietary factors are known to affect colorectal cancer development and prognosis. The protective roles of diets rich in fruits and vegetables have been previously reported to contain high levels of cancer-fighting phytochemicals. Anthocyanins are the most abundant flavonoid compounds that are responsible for the bright colors of most blue, purple, and red fruits and vegetables, and have been shown to contribute to the protective effects of fruits and vegetables against cancer and other chronic diseases. Berries and grapes are the most common anthocyanin-rich fruits with antitumor effects. The antitumor effects of anthocyanins are determined by their structures and bioavailability as well as how they are metabolized. In this review, we aimed to discuss the preventive as well as therapeutic potentials of anthocyanins in CRC. We summarized the antitumor effects of anthocyanins and the mechanisms of action. We also discussed the potential pharmaceutical application of anthocyanins in practice.

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“…The anticancer effect of Prunus spinosa extract in combination with NAC has been extensively studied on 2D, 3D and in vivo models of colon cancer [ 6 ]. The treatments on the 2D model confirmed the previous results and showed the inhibiting effect on the migration ability of the HCT116 cell.…”

Section: Experimental Evidence Of Dual Antioxidant or Pro-oxidant Effect Of Prunus Spinosa Extract On Colorectal Cancementioning

confidence: 99%

“…Finally, we present an experimental analysis performed in our laboratory, using colorectal carcinoma cell line (HCT116), treated with a natural compound derived from Prunus spinosa , Trigno ecotype (Trigno M) [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Role of Natural Antioxidant Products in Colorectal Cancer Disease: A Focus on a Natural Compound Derived from Prunus spinosa, Trigno Ecotype

Condello¹,

Meschini²

2021

Cells

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Colorectal cancer (CRC) is on the rise in industrialized countries, which is why it is important to find new compounds that are effective, with little or no adverse health effects. CRC arises from some cells of the epithelium which, following a series of genetic or epigenetic mutations, obtain a selective advantage. This work consists of a review on endogenous and exogenous antioxidant products that may have an efficacy in the treatment of CRC and an experimental study, in which the treatment was carried out with a natural compound with antitumor and antiproliferative activity, Prunus spinosa Trigno ecotype, patented by us, on HCT116 colorectal carcinoma cell line. The superoxide content was quantified after the treatments at different concentrations (2, 5, or 10 mg/mL) by means of the DHR123 probe; loss of the mitochondrial membrane potential with the tetramethylrodamine methyl ester (TMRM) cationic probe and reduced glutathione content (GSH) from monochlorobimane (MCB). This study revealed the importance of a careful choice of the concentration of the natural compound to be used in the CRC, due to the presence of a paradoxical effect, both antioxidant and pro-oxidant, depending on the different physiological conditions of the cell.

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Anticancer activity of “Trigno M”, extract of Prunus spinosa drupes, against in vitro 3D and in vivo colon cancer models

Cited by 26 publications

References 28 publications

Dietary Effects of Anthocyanins in Human Health: A Comprehensive Review

Dietary Effects of Anthocyanins in Human Health: A Comprehensive Review

Anthocyanins in Colorectal Cancer Prevention Review

Role of Natural Antioxidant Products in Colorectal Cancer Disease: A Focus on a Natural Compound Derived from Prunus spinosa, Trigno Ecotype

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