Biochemical Pharmacology volume 82, issue 5, P464-475 2011 DOI: 10.1016/j.bcp.2011.05.030 View full text
Chern Chiuh Woo, Ser Yue Loo, Veronica Gee, Chun Wei Yap, Gautam Sethi, Alan Prem Kumar, Kwong Huat Benny Tan

Abstract: Thymoquinone (TQ), an active ingredient of Nigella sativa, has been reported to exhibit anti-oxidant, anti-inflammatory and anti-tumor activities through mechanism(s) that is not fully understood. In this study, we report the anticancer effects of TQ on breast cancer cells, and its potential effect on the PPAR-γ activation pathway. We found that TQ exerted strong anti-proliferative effect in breast cancer cells and, when combined with doxorubicin and 5-fluorouracil, increased cytotoxicity. TQ was found to incr…

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