Anticancer activity of limonoid from <i>Khaya senegalensis</i>

Zhang, Huaping; Wang, Xi; Chen, Feng; Androulakis, X Michelle; Wargovich, Michael J.

doi:10.1002/ptr.2148

Cited by 66 publications

(27 citation statements)

References 18 publications

(16 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, that study also examined the inhibitory mechanism and determined that the bark extracts had both antiproliferative and pro-apoptotic activities. Similarly, the growth of SiHa (cervical cancer cells) was inhibited by K. senegalensis stem bark extracts, 13 paralleling the HeLa cervical carcinoma proliferation results reported in our study. The previous study also examined the phytochemistry of the bark extracts and correlated the antiproliferative activity with limonoids.…”

Section: Discussionsupporting

confidence: 90%

“…Our findings support previous studies which have also reported antibacterial properties for K. senegalensis extracts from other plant parts. 12,13,16,18 The K. senegalensis bark extracts screened in our study were particularly potent inhibitors of P. mirabilis and P. vulgaris growth, with MIC values of several extracts substantially <500µg/mL. This activity is noteworthy as P. mirabilis has been implicated in urinary tract infections (UTI's) and the induction of rheumatoid arthritis (RA).…”

Section: Discussionmentioning

confidence: 73%

“…It is therefore likely that these extracts may contain substantial levels of similar limonoids, khayanolides and other triterpenoids as previously reported for the bark extracts. 13 Phytochemical isolation and identification studies using different analytical methods are required to confirm this. Whilst this study provides insight into the phytochemical compositions of the K. senegalensis extracts, it is noteworthy that no single technique will detect and identify all compounds responsible for any therapeutic property in an extract.…”

Section: Discussionmentioning

confidence: 99%

“…Whilst several studies verifying bioactivities associated with ethnobotanical usage exist, many of these reports have focussed on the bark, and to a lesser extent, the leaf. Bark extracts have been reported to have good anticancer 6,13,14 and anti-inflammatory properties 6 are good immunostimulants 11 and are insect deterrents. 8 K. senegalensis bark extracts have potential in the treatment of diabetes and have been reported to have anti-hyperglycemic activity comparable to glibenclamide.…”

Section: An Examination Of the Antimicrobial And Anticancer Propertiementioning

confidence: 99%

See 3 more Smart Citations

An examination of the Antimicrobial and Anticancer Properties of Khaya senegalensis (Desr.) A. Juss. Bark Extracts

Rabadeaux¹,

Vallette²,

Sirdaarta³

et al. 2017

Phcog J

View full text Add to dashboard Cite

Background: Khaya senegalensis (Desr.) A. Juss. is a common component of the pharmacopeia's of multiple African groupings which inhabit the areas in which it grows. Amongst these groups there is a myriad of medicinal uses in the treatment of a wide variety of bacterial, fungal and protozoal infections, as well as in the treatment of cancers. This study was undertaken to test K. senegalensis bark extracts for the ability to inhibit microbial and cancer cell growth, and thus to validate traditional African medicinal usage of this plant in treating a variety of diseases. Materials and Methods: K. senegalensis bark powder was extracted by both solvent maceration and subcritical fluid extraction (SFE). The extracts were tested for the ability to inhibit bacterial and G. duodenalis growth. Inhibition of Caco-2 and HeLa cancer cells was evaluated using MTS-based colorimetric cell proliferation assays. Toxicity was evaluated using an Artemia franciscana nauplii bioassay and GC-MS headspace analysis was used to identify phytochemical components. Results: K. senegalensis bark extracts displayed strong inhibitory activity against bacterial triggers of several autoimmune inflammatory diseases. The growth inhibitory activity of the methanolic and subcritical extracts was particularly noteworthy against P. mirabilis (MIC values of 185 and 211µg/mL, respectively against the reference strains). These extracts were similarly potent growth inhibitors of K. pneumoniae and A. baylyi, and were moderate inhibitors (MIC >1000µg/mL) of P. aeruginosa and S. pyogenes growth. The methanolic and subcritical K. senegalensis extracts were also potent inhibitors of G. duodenalis (187 and 328µg/mL, respectively), as well as Caco-2 (268 and 470µg/mL, respectively) and HeLa carcinomas (155 and 174µg/mL, respectively). GC-MS analysis of the SFE extract revealed relative abundances of a variety of mono-and sesquiterpenoids. Furthermore, all K. senegalensis bark extracts were non-toxic in the Artemia franciscana toxicity assay, indicating their safety for therapeutic use. Conclusion: These studies validate traditional African therapeutic usage of K. senegalensis in the treatment of microbial infections, autoimmune inflammatory diseases and some cancers.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Section: An Examination Of the Antimicrobial And Anticancer Propertiementioning

confidence: 99%

See 2 more Smart Citations

An examination of the Antimicrobial and Anticancer Properties of Khaya senegalensis (Desr.) A. Juss. Bark Extracts

Rabadeaux¹,

Vallette²,

Sirdaarta³

et al. 2017

Phcog J

View full text Add to dashboard Cite

show abstract

“…Activities such as insecticidal, insect antifeedant, antibacterial, antifungal, antimalarial, anticancer, and antiviral have been reported. [1][2][3][4][5] In the course of our studies on the bark extract of Chisocheton ceramicus, 6,7) we have isolated five new limonoids, ceramicines E-I (1-5). Here we sought to report the isolation, structure elucidation, and cytotoxic activity of 1-5 isolated from C. ceramicus.…”

mentioning

confidence: 99%

Ceramicines E-I, New Limonoids from Chisocheton ceramicus

Wong

Shimada

Nagakura

et al. 2011

CHEMICAL & PHARMACEUTICAL BULLETIN

View full text Add to dashboard Cite

Five new limonoids, ceramicines E-I (1-5), have been isolated from the bark of Chisocheton ceramicus. The structures and relative stereochemistry of them were fully elucidated based on 1D-and 2D-NMR data. Ceramicines E-I (1-5) exhibited moderate cell growth inhibitory activities on a range of cell lines (HL-60, A549, MCF7, and HCT116). The absolute structure of previously isolated ceramicine B (6) was also elucidated by circular dichroism (CD) and X-ray analysis.

show abstract

Review on medicinal plants and natural compounds as anti-Onchocerca agents

2018

View full text Add to dashboard Cite

Onchocerciasis is a filarial vector borne disease which affects several million people mostly in Africa. The therapeutic approach of its control was based on a succession of drugs which always showed limits. The last one: ivermectin is not the least. It was shown to be only microfilaricidal and induced resistance to the human parasite Onchocerca volvulus. The approach using medicinal plants used in traditional medicine is a possible alternative method to cure onchocerciasis. Onchocerca ochengi and Onchocerca gutturosa are the parasite models used to assess anthelmintic activity of potentially anthelmintic plants. Numerous studies assessed the in vitro and/or in vivo anthelmintic activity of medicinal plants. Online electronic databases were consulted to gather publications on in vitro and in vivo studies of anti-Onchocerca activity of plants from 1990 to 2017. Globally, 13 plant families were investigated for anti-Onchocerca activity in 13 studies. The most active species were Anacardium occidentale, Euphorbia hirta and Acacia nilotica each with an LC value of 2.76, 6.25 and 1.2 μg/mL, respectively. Polycarpol, voacamine, voacangine, ellagic acid, gallic acid, gentisic acid, 3-O-acetyl aleuritolic acid and (-)-epigallocatechin 3-O-gallate were the isolated plant compounds with anti-Onchocerca activity. Most of the assessed extract/compounds showed a good safety after in vivo acute toxicity assays and/or in vitro cytotoxicity test. The exception was the ethanol extract of Trichilia emetica, which killed completely and drastically mice at a dose of 3000 mg/kg. Several plant groups of compounds were shown active against Onchocerca sp. such as tannins, alkaloids, triterpenoids and essential oils. Nevertheless, none of the active compounds was subjected to clinical trial, to assessment of its diffusibility through nodular wall or its capability to induce genetic resistance of Onchocerca sp.

show abstract

Anticancer activity of limonoid from Khaya senegalensis

Cited by 66 publications

References 18 publications

An examination of the Antimicrobial and Anticancer Properties of Khaya senegalensis (Desr.) A. Juss. Bark Extracts

An examination of the Antimicrobial and Anticancer Properties of Khaya senegalensis (Desr.) A. Juss. Bark Extracts

Ceramicines E-I, New Limonoids from Chisocheton ceramicus

Review on medicinal plants and natural compounds as anti-Onchocerca agents

Contact Info

Product

Resources

About