Anticancer activity of essential oils: a review

Bhalla, Yashika; Gupta, V. K.; Jaitak, Vikas

doi:10.1002/jsfa.6267

Cited by 239 publications

(145 citation statements)

References 132 publications

(131 reference statements)

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“…Resultados de estudios indican que los AEs y componentes aislados poseen actividad in vitro anticancerígena y en ratones de laboratorio pueden reducir el tamaño de tumores inducidos (Bhalla et al, 2013;Lesgards et al, 2014;Sobral et al, 2014;Manion y Widder, 2017). Existe suficiente evidencia para concluir que los AEs pueden servir como puntos de partida para desarrollo de medicamentos herbales y descubrimiento de nuevos fármacos.…”

Section: Introductionunclassified

Actividad antiproliferativa de aceites esenciales de plantas cultivadas en Colombia

et al. 2018

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RESUMENColombia posee gran diversidad de plantas medicinales, pero pocas han sido objeto de investigación. En este trabajo se evaluó la actividad antiproliferativa de aceites esenciales obtenidos por hidrodestilación asistida por microondas. Se analizaron 15 muestras de 11 especies en ensayos del MTT en células cancerosas MCF-7, HeLa y HepG-2 y se incluyeron células normales humanas (HEK293) y de animales (Vero y BF16F10) para evaluar selectividad. La composición química de muestras activas se determinó por cromatografía de gases acoplada a espectrometría de masas (GC-MS). Aceites esenciales de cuatro especies mostraron actividad antiproliferativa (CI 50 : 50 μg/mL) en células HeLa y/o MCF-7, en el siguiente rango (índice de selectividad en paréntesis): Piper cumanense H.B.K. (4,7) > Piper subflavum var. espejuelanum C.DC (3,9) > Salvia officinalis L. (3,6) > Piper eriopodom (Miq.) C. DC. (3,1). Ninguna muestra fue activa en células HepG-2. El análisis por CG-MS identificó β-cariofileno, α-copaeno, β-pineno, α-pineno y linalol como componentes mayoritarios. Los aceites esenciales activos pueden ser puntos de partida para desarrollo de medicamentos herbales para cuidado paliativo del cáncer.Palabras clave: aceite esencial, apoptosis, cáncer, fitoterapia, MTT. ABSTRACTColombia has a great diversity of medicinal plants, but few have been investigated. In this work, the antiproliferative activity of essential oils obtained by microwave-assisted hydrodistillation was evaluated. Fifteen samples from 11 species were analyzed in MTT assays in cancer cells MCF-7, HeLa and HepG-2, and normal human cells (HEK293) and animal cells (Vero and B16F10) were included to evaluate selectivity. The chemical composition of the active oils was determined by gas chromatography coupled to mass spectrometry (GC-MS). Essential oils from four species showed antiproliferative activity (IC 50 : <50 μg / mL) in HeLa and / or MCF-7 cells, in the following range (selectivity index in parenthesis): Piper cumanense H.B.K. (4.7) > Piper subflavum var. espejuelanum C. DC (3.9) > Salvia officinalis Linneo. (3.6) > Piper eriopodom (Miq.) C.DC. (31). The CG-MS analysis identified β-caryophyllene, α-copaene, β-pinene, α-pinene and linalool as major components. Active essential oils could serve as starting points to develop herbal medicines for cancer palliative care.

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Section: Introductionunclassified

Actividad antiproliferativa de aceites esenciales de plantas cultivadas en Colombia

et al. 2018

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“…They are an important source of potential therapeutic compounds (Sherry et al, 2013). Essential oil constituents from aromatic herbs and dietary plants include monoterpenes, sesquiterpenes, oxygenated monoterpenes, oxygenated sesquiterpenes, and phenolics, among others (Bhalla et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

In vitro cytotoxic, genotoxic, and oxidative effects of acyclic sesquiterpene farnesene

Çelik¹,

Toğar²,

Türkez³

et al. 2014

Turk J Biol

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IntroductionEssential oils are complex volatile natural compounds formed by aromatic plants as secondary metabolites. They are an important source of potential therapeutic compounds (Sherry et al., 2013). Essential oil constituents from aromatic herbs and dietary plants include monoterpenes, sesquiterpenes, oxygenated monoterpenes, oxygenated sesquiterpenes, and phenolics, among others (Bhalla et al., 2013).Sesquiterpenes, which are one of the most common terpenes, are a class of natural products with a diverse range of attractive industrial properties (Wang et al., 2011;Scalcinati et al., 2012). They are compounds containing 3 isoprene units, which have 15 carbons and 24 hydrogens per molecule (C 15 H 24 ). There are more than 10,000 kinds of sesquiterpenes (Davis and Croteau, 2000). They have long been investigated for biological activities including anticarcinogenic (

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“…have attracted considerable research interest due to their ability to inhibit cell proliferation and, thus, reduce cancer progression 4 . Essential oils are considered promising substances for investigation of this therapeutic goal, as they appear to contain interesting dietary phytochemicals capable of suppressing the initiation of carcinogenesis, cellular hyperproliferation, inflammatory processes, and malignant transformation 5 . Citrus hystrix DC.…”

Section: Introductionmentioning

confidence: 99%

Cytostatic, cytotoxic, and antibacterial activities of essential oil isolated from Citrus hystrix

Borusiewicz¹,

Trojanowska²,

Paluchowska³

et al. 2017

ScienceAsia

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ABSTRACT:The essential oil obtained from the peel of Citrus hystrix fruits is a colourless or light yellow liquid with a strong citrus scent. It was analysed for its constituents using gas chromatography/mass spectroscopy. The major components of the oil were β-pinene, limonene, terpinen-4-ol, α-pinene, α-terpinene, γ-terpinene, and α-terpineol. The antibacterial activity of C. hystrix essential oil was tested by disc diffusion and serial macrodilution methods against 50 multidrug-resistant Acinetobacter baumannii strains. The results confirmed its good activity expressed by minimal inhibitory concentration values in the range of 0.125-1 µl/ml. The effect on the viability and proliferation of normal human skin fibroblasts (HSF) and the human melanoma cells (WM793 and A375) was also examined. The observed cytostatic and cytotoxic activities were dependent on the dose of tested oil and the incubation time. Melanoma cells (WM793 and A375) were more sensitive to the essential oil from C. hystrix peel than normal cells (HSF). These results suggest a need for more detailed research on its possible use in therapy.

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Anticancer activity of essential oils: a review

Cited by 239 publications

References 132 publications

Actividad antiproliferativa de aceites esenciales de plantas cultivadas en Colombia

Actividad antiproliferativa de aceites esenciales de plantas cultivadas en Colombia

In vitro cytotoxic, genotoxic, and oxidative effects of acyclic sesquiterpene farnesene

Cytostatic, cytotoxic, and antibacterial activities of essential oil isolated from Citrus hystrix

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