Anticancer activity of Aloe vera and Calligonum comosum extracts separetely on hepatocellular carcinoma cells

Antimicrobial Activity and Phytochemical Screening of Aloe vera (Aloe barbadensis Miller)

“…It is revealed that it has conspicuous pharmacological activities such as antibacterial (Subramanian et al, 2006;Arunkumar and Muthuselvam, 2009;Saritha et al, 2010;Fani and Kohanteb, 2012;Nejatzadeh-Barandozi, 2013), antifungal (Bajwa et al, 2007;Rosca-Casian et al, 2007;Khaing, 2011;Sitara et al, 2011), antiviral (Zandi et al, 2007), antioxidant (Baradaran et al, 2013;Ray et al, 2013;Kang et al, 2014), cytotoxic (Jose et al, 2014;Shalabi et al, 2015), antidiabetic (Tanaka et al, 2006;Choudhary et al, 2014;Suleyman et al, 2014), anti-inflammatory (Vijayalakshmi et al, 2012;Bhattacharjee et al, 2014), antitumor (El-Shemy et al, 2010;Srihari et al, 2015), nephroprotective (Iftikhar et al, 2015;Virani et al, 2016), antiulcer (Borra et al, 2011) and anti-aging effects which can be used as a moisturizing agent to cure cardiovascular diseases as well as to enhance the immune system (Chatterjee et al, 2013). It is used as an herbal medicine since long time which contains more than 100 bioactive constituents.…”

Metabolomic profiling of cancer cells to Aloe vera extract by 1HNMR spectroscopy

“…It also has anti tumorigenic properties and increases expression of p53 gene and Bcl2 as demonstrated on human hepatocellular carcinoma cells [16,17]. Ehrlich ascites carcinoma in Swiss albino mice were apparently healed by Aloe vera extract by reversion of their hematological profiles towards normal levels and a decrease of peroxidation enzymes of lipid peroxidation and increased the levels of reduced glutathione and other antioxidant enzymes, like superoxide dismutase, catalase and glutathione peroxidase [16]. The anti- cancer activity of Aloe vera on Raji cells was exhibited by IC50 of 40µg/ml in vitro confirming the above results.…”

“…Anti-cancer properties of Aloe vera have been reported from 2010 when its anti-proliferation effects on some types of cancer cells in vitro such as lung, squamous, glioma, and neuro-ectodermal were described [15,16]. It also has anti tumorigenic properties and increases expression of p53 gene and Bcl2 as demonstrated on human hepatocellular carcinoma cells [16,17].…”

“…Anti-cancer properties of Aloe vera have been reported from 2010 when its anti-proliferation effects on some types of cancer cells in vitro such as lung, squamous, glioma, and neuro-ectodermal were described [15,16]. It also has anti tumorigenic properties and increases expression of p53 gene and Bcl2 as demonstrated on human hepatocellular carcinoma cells [16,17]. Ehrlich ascites carcinoma in Swiss albino mice were apparently healed by Aloe vera extract by reversion of their hematological profiles towards normal levels and a decrease of peroxidation enzymes of lipid peroxidation and increased the levels of reduced glutathione and other antioxidant enzymes, like superoxide dismutase, catalase and glutathione peroxidase [16].…”

In vitro antiapoptotic effects of the calligonum extract on spermatogonial stem cells

“…Studies have shown that the cytotoxic activity of Calligonum comosum might be through modulation of apoptosis (17). …”