Anticancer activities of marine macroalgae: status and future perspectives

Gopeechund, Arvind; Bhagooli, Ranjeet; Neergheen, Vidushi S.; Bolton, John J.; Bahorun, Theeshan

doi:10.1016/b978-0-12-819541-3.00014-1

Cited by 9 publications

(5 citation statements)

References 118 publications

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“…Cyanobacteria (blue-green algae) are well known for their production of antibiotics and active pharmaceutical compounds (API) [1,2]. Despite increasing interest, the economic utilisation of macroalgae for their antioxidant [3,4], anti-tumour [4], and antiviral properties [5] remains in its infancy. They contain complex structure compounds with a variety of biological activities, such as terpenes (antioxidant, anti-tumour, antifungal, etc.…”

Section: Introductionmentioning

confidence: 99%

In Vivo and In Vitro Antioxidant Activity of Less Polar Fractions of Dasycladus vermicularis (Scopoli) Krasser 1898 and the Chemical Composition of Fractions and Macroalga Volatilome

et al. 2022

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The present research is a comprehensive investigation of Dasycladus vermicularis (Scopoli) Krasser 1898 from the Adriatic Sea (Croatia) regarding volatilome–volatile organic compounds (VOCs, mostly nonpolar compounds) and less polar nonvolatile compounds for the first time. Headspace solid-phase microextraction (HS-SPME) and hydrodistillation (HD) were used showing the great volatilome variability among fresh (HS-FrDV and HD-FrDV) and dried (HS-DrDV and HD-DrDV) samples after GC–MS analysis. Aromatic aldehydes were dominant in both fresh and air-dried HS samples with benzaldehyde as the most abundant in fresh samples and decreasing 2.7–3.7 times after drying together with 2-phenylbut-2-enal that was not present after drying. Aliphatic compounds (unsaturated hydrocarbons in HS-FrDV; saturated hydrocarbons in HS-DrDV) were also present. C11-hydrocarbons (dictyopterpene C’ and dictyopterpene D’) were detected in HS-FrDV. (E)-Phytol was the most dominant compound in HD-FrDV and HD-DrDV. Diterpene alcohols (cembra-4,7,11,15-tetraen-3-ol and (Z)-falcarinol) and sesquiterpene alcohol, cubenol, were dominant in HD-FrDV, and their abundance decreased after drying. C13-norisoprenoides (α-ionone and β-ionone) increased after drying. Aliphatic compounds were present in both HD-FrDV and HD-DrDV samples. The less polar nonvolatile compounds in the obtained fractions F3 and F4 were analysed and identified by UHPLC-ESI(+)-HRMS. Identified compounds belonged to a group of pigments (7 compounds), fatty acid derivatives (13 compounds), as well as steroids and terpenes (10 compounds). Porphyrin-based compounds (C55H74N4O5–7), xanthophylls, sphingolipid compounds, fatty acid amides, and phytosterols represented the majority of identified compounds. By implementing both in vitro and in vivo assays for antioxidant activity determination, F3 showed a higher activity than F4. Inhibitory concentrations (IC50) for F3 and F4 were 498.00 ± 0.01 µg/mL and 798.00 ± 0.81 µg/mL, respectively, while a 1.5-fold reduction in the ROS level was observed after pre-treatment of zebrafish larvae with 45 µg/mL of F3.

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Section: Introductionmentioning

confidence: 99%

In Vivo and In Vitro Antioxidant Activity of Less Polar Fractions of Dasycladus vermicularis (Scopoli) Krasser 1898 and the Chemical Composition of Fractions and Macroalga Volatilome

et al. 2022

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“…The use of macroalgae for therapeutic purposes has a long history, but the search for biologically active substances from these organisms is quite recent. Numerous studies have demonstrated the biological properties of macroalgae extracts and compounds, including antioxidant, anti-inflammatory [ 20 ], antithrombotic, anticoagulant and coagulant [ 21 ], antimicrobial [ 22 ], and anticancer [ 23 ]. In addition, macroalgae have been demonstrated to exert biological properties applicable to cosmetic products, such as photo-protection, anti-aging, or anti-cellulite ( Table 1 ).…”

Section: Possible Exploitation Of the Invasive Speciesmentioning

confidence: 99%

The Use of Invasive Algae Species as a Source of Secondary Metabolites and Biological Activities: Spain as Case-Study

et al. 2021

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In the recent decades, algae have proven to be a source of different bioactive compounds with biological activities, which has increased the potential application of these organisms in food, cosmetic, pharmaceutical, animal feed, and other industrial sectors. On the other hand, there is a growing interest in developing effective strategies for control and/or eradication of invasive algae since they have a negative impact on marine ecosystems and in the economy of the affected zones. However, the application of control measures is usually time and resource-consuming and not profitable. Considering this context, the valorization of invasive algae species as a source of bioactive compounds for industrial applications could be a suitable strategy to reduce their population, obtaining both environmental and economic benefits. To carry out this practice, it is necessary to evaluate the chemical and the nutritional composition of the algae as well as the most efficient methods of extracting the compounds of interest. In the case of northwest Spain, five algae species are considered invasive: Asparagopsis armata, Codium fragile, Gracilaria vermiculophylla, Sargassum muticum, and Grateulopia turuturu. This review presents a brief description of their main bioactive compounds, biological activities, and extraction systems employed for their recovery. In addition, evidence of their beneficial properties and the possibility of use them as supplement in diets of aquaculture animals was collected to illustrate one of their possible applications.

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“…Moreover, no study has documented the effect of steadily increasing temperature on non-geniculate RCAs, under current and predicted climate change scenarios. It is noteworthy that limited studies on RCAs have been conducted around Mauritius in the Western Indian Ocean, though studies on other macroalgae of the Republic of Mauritius have been documented (Bolton et al 2012;Somanah et al 2012;Mattio et al 2013;Ramah et al 2014Ramah et al , 2021aKaullysing et al 2016;Bhagooli and Kaullysing 2019;Gopeechund et al 2020;Bhagooli et al 2021a,c,d;Narrain et al 2023). To explore the effect of temperature on the photo-physiology of non-geniculate RCAs, two species were used to assess the photo-physiological thermal tolerance in laboratory-based experiments.…”

Section: Introductionmentioning

confidence: 99%

The red coralline alga Hydrolithon onkodes, an attractor of coral larvae, is photosynthetically more susceptible to thermal stress than Lithophyllum incrustans

PERRINE

MUNDIL²,

Kaullysing

et al. 2023

Indo Pac J Ocean Life

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Abstract. Perrine MJS, Mundil S, Kaullysing D, Bhagooli R. 2023. The red coralline alga Hydrolithon onkodes, an attractor of coral larvae, is photosynthetically more susceptible to thermal stress than Lithophyllum incrustans. Indo Pac J Ocean Life 7: 91-99. Red Coralline Algae (RCAs) are important components of coral reefs and are involved in reef-building via calcification, cementation, the synthesis of anti-fouling compounds and of chemicals to aid recruitment, settlement and metamorphosis of reef species. This study aimed to investigate the distribution of RCAs at four sites around Mauritius Island and the effects of thermal stress on the effective photosynthetic yield of photosystem II (FPSII) of two species of RCA namely, Lithophyllum incrustans (Philippi, 1837) and Hydrolithon onkodes, known to attract coral larvae. Out of the nine RCA species observed, two non-geniculate RCAs, H. onkodes and L. incrustans, were among the most dominant, especially at the lagoonal and reef zones of the four studied sites Flic en Flac, Belle Mare, Trou aux Biches and Flat Island. These two RCAs were collected, acclimated for 24 hours on a 12h:12h dark-light cycle and then exposed to 27°C, 30°C and 33°C for 3 (T3), 6 (T6) and 19 (T19) hours. After 3, 6 and 19 hours, relative change in FPSII compared to initial (T0) was used for comparison among tested species. At 27°C the FPSII did not fluctuate significantly during the experiment for both RCAs. At a temperature 30°C only H. onkodes significantly decreased from 0.541 ± 0.54 at T0 to 0.445 ± 0.116 at T19. At 33°C, L. incrustans showed a significant decline of 24.82 ± 7.4% while H. onkodes decreased by 90 ± 12.6%. Visual observations revealed that H. onkodes changed from the initial healthy-looking color of light grey to pale purple after thermal exposure. These findings indicate that the coral larvae-attracting H. onkodes is more susceptible than the L. incrustans to thermal stress, implying subsequent possible impacts on coral recruitment process especially in the wake of climate change-driven ocean warming.

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Anticancer activities of marine macroalgae: status and future perspectives

Cited by 9 publications

References 118 publications

In Vivo and In Vitro Antioxidant Activity of Less Polar Fractions of Dasycladus vermicularis (Scopoli) Krasser 1898 and the Chemical Composition of Fractions and Macroalga Volatilome

In Vivo and In Vitro Antioxidant Activity of Less Polar Fractions of Dasycladus vermicularis (Scopoli) Krasser 1898 and the Chemical Composition of Fractions and Macroalga Volatilome

The Use of Invasive Algae Species as a Source of Secondary Metabolites and Biological Activities: Spain as Case-Study

The red coralline alga Hydrolithon onkodes, an attractor of coral larvae, is photosynthetically more susceptible to thermal stress than Lithophyllum incrustans

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