2005
DOI: 10.1111/j.1365-2249.2005.02864.x
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Abstract: SummaryBoth viral effect and immune-mediated mechanism are involved in the pathogenesis of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infection. In this study, we showed that in SARS patient sera there were autoantibodies (autoAbs) that reacted with A549 cells, the type-2 pneumocytes, and that these autoAbs were mainly IgG. The autoAbs were detectable 20 days after fever onset. Tests of non-SARS-pneumonia patients did not show the same autoAb production as in SARS patients.

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Cited by 57 publications
(55 citation statements)
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“…One monoclonal antibody (S110) was also found that did not mediate enhancement. This is consistent with other studies that have shown cross-reactivity between anti-S2 (aa927-937 and aa942-951) and lung cell antigens Lin et al, 2005b).…”
Section: Vaccinessupporting
confidence: 93%
“…One monoclonal antibody (S110) was also found that did not mediate enhancement. This is consistent with other studies that have shown cross-reactivity between anti-S2 (aa927-937 and aa942-951) and lung cell antigens Lin et al, 2005b).…”
Section: Vaccinessupporting
confidence: 93%
“…SARS-CoV starts as a mild pneumonia and clinical worsening typically appears at a late stage of infection (> 1 week), when virus load in the lungs starts to decrease and virus specific antibodies appear in the circulation. Respiratory dysfunction is caused by diffuse alveolar damage (DAD), which is believed to be triggered by an immunopathological reaction [48,49]. In PRCV we have seen also DAD appearing at 7-9 DPI when antibodies were already detectable in the blood (Fig.…”
Section: Discussionmentioning
confidence: 70%
“…Auto-immune responses may also be involved in the pathogenesis of SARS. In vitro experiments have shown that auto-antibodies obtained from sera of SARS patients induce cytotoxicity against epithelial and endothelial cells (Lin et al, 2005;Yang et al, 2005a,b).…”
Section: Pathogenesis Of Sarsmentioning
confidence: 99%