Antibody Responses to SARS-CoV-2 at 8 Weeks Postinfection in Asymptomatic Patients

Abstract

RESEARCH LETTERS We compared levels of severe acute respiratory syndrome coronavirus 2 neutralizing antibodies in recovery plasma from 7 completely asymptomatic coronavirus disease patients with those in symptomatic patients in South Korea. We found that serologic diagnostic testing was positive for 71% (5/7) of completely asymptomatic patients, but neutralizing antibody response occurred in all 7 patients. as informing the public about food shortage while reassuring the public that supply will arrive in a few days. China has provided free, country-wide psychosocial support, funded by the government and institutions (5-7). The accessibility is remarkable compared with that in other countries that depend on health insurance benefits. Our review suggests that China has overcome resource shortages with coordination and resource allocation in its mental health response. The government, universities, and academic societies provide coordination, and independent organizations provide local support. We recommend integration of assessment in direct support, monitoring of organizations, and advocating for affected persons. These recommendations can inform how other countries can overcome shortage of mental health resources when facing this pandemic.

Detection, prevalence, and duration of humoral responses to SARS-CoV-2 under conditions of limited population exposure

“…Through campus screening efforts, we also identified 6 PCR+ individuals who either never developed symptoms or had only a brief and mild headache or anosmia. Although previous reports suggested that such individuals may infrequently seroconvert or frequently serorevert (Long et al, 2020a;Sekine et al, 2020), all such individuals in our cohort showed seroreactivity to RBD, S2, and all but one to N (Figures S3A-C), consistent with other recent studies (Choe et al;Ko et al, 2020). Given that older adults, as well as those of male sex, exhibit disproportional morbidity and mortality from COVID-19, we also sought to test whether humoral immunity in these subjects may be quantitatively reduced (Liu et al, 2020).…”

Convalescent plasma treatment of severe COVID-19: a propensity score–matched control study

“…3b) and in a larger cohort of individuals screened for serum antibodies within our health system 25 . Others have reported similar findings [26][27][28] . We did not observe a correlation between donor serum neutralizing titers and convalescent plasma-recipient outcomes (Fig.…”

Antibody Responses to SARS-CoV-2: Let’s Stick to Known Knowns

“…Their increased and possibly continued presence in severely ill patients underscores the nature of this humoral response as an "emergency supply system," ensuring the rapid production of protective Abs, both switched and nonswitched. Asymptomatic patients and those with mild disease exhibit lower overall Ab responses but do also possess neutralizing titers (33)(34)(35). As convalescence begins, B cell responses shift from "emergency supply" to the development of long-lived responses in germinal center responses, which are geared toward developing protection from future re-encounters.…”