2012
DOI: 10.5581/1516-8484.20120071
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Abstract: Objective To evaluate viral vaccine antibody levels in children with acute lymphoblastic leukemia after chemotherapy and after vaccine booster doses. Methods Antibody levels against hepatitis B, rubella, measles and mumps vaccine antigens were evaluated in 33 children after completing chemotherapy (before and after vaccine booster doses) and the results were compared to the data of 33 healthy children matched for gender, age and social class. Results After chemotherapy, 75.9%, 67.9%, 59.3% and 51.7% of the pat… Show more

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Cited by 6 publications
(33 citation statements)
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“…In this issue Viana et al ( 1 ) discuss immunity after chemotherapy for acute lymphoblastic leukemia whose recostitution does not garantee protection against vaccine preventable disease. Current treatment for acute lymphoblastic leukaemia (ALL) cures the majority of patients but as a consequence it causes severe immunosuppression which may even last after completing chemotherapy.…”
mentioning
confidence: 99%
“…9 However, other studies have also shown no effect of age on posttreatment vaccine titers in children with ALL. 16,17 While these studies and ours showed that some trends do exist, what is important is that considerable portions of individuals exhibit loss of immunogenicity against VPDs following chemotherapy in all ages throughout these studies.…”
Section: Loss Of Vaccine Response Is Significant and Variable After Cmentioning
confidence: 58%
“…Immune competence decreases not only due to chemotherapy-induced neutropenia, but also due to the reduction of serum antibody titers gained from previous immunizations [2].The damage to the immune system varies with the age of the patient, the type of cancer, and the intensity of the chemotherapy used to treat it [3].There is a reduction of vaccine-antigen specific antibody concentration after completion of chemotherapy with or without radiotherapy. The immune system recovers to normal three to six months aftercompletion of chemotherapy [4].Therefore children with cancer after finishing chemotherapy may become susceptible to infectious diseases [5].…”
Section: Introduction:-mentioning
confidence: 99%