Antibody-independent functions of B cells during viral infections

Upasani, Vinit; Rodenhuis-Zybert, Izabela A.; Cantaert, Tineke

doi:10.1371/journal.ppat.1009708

Cited by 44 publications

(30 citation statements)

References 99 publications

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“…B cells also contribute to antiviral immunity through mechanisms other than antibody production, including cytokine secretion and presentation of antigen to T cells [ 39 ]. ABCs secrete an array of cytokines with substantial production of IFNγ, tumor necrosis factor (TNF), and interleukin 6 (IL-6) [ 33 – 35 ].…”

Section: Introductionmentioning

confidence: 99%

Age-associated B cells in viral infection

Mouat

Horwitz

2022

PLoS Pathog

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Age-associated B cells (ABCs) are a recently identified, unique B cell population that displays both protective and pathogenic characteristics, depending on the context. A major role of ABCs is to protect from viral infection. ABCs expand during an array of viral infections and display various functional capacities, including secretion of antibodies and activation of T cells. Following resolution of infection, ABCs appear to persist and play a crucial role in memory and recall responses. Here, we review the currently understanding of ABCs in the antiviral response in both humans and mice. We discuss avenues for future research, including the impact of sex on the ABC population and heterogeneity of ABCs between contexts.

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Section: Introductionmentioning

confidence: 99%

Age-associated B cells in viral infection

Mouat

Horwitz

2022

PLoS Pathog

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“…Meanwhile, there was a correlation between eosinophils and B cells in this study. Recent studies [21][22][23] have found that there is a correlation between B cells and viral infections because B cells can secrete interleukin-10 (IL-10), IL-35 and transforming growth factor-β and play a negative immunomodulatory role. This reminds us that we should pay attention to the role of innate immunity in VZV infection, as this will be helpful in judging the severity of the disease and selecting appropriate treatment.…”

Section: Discussionmentioning

confidence: 99%

Predictive role of blood eosinophils in adult varicella patients

et al. 2022

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The study aimed to explore the relationship between eosinophils and the prognosis of varicella in adults. We retrospectively reviewed the medical records of patients who were hospitalized in The Fifth People's Hospital of Suzhou with a diagnosis of adult varicella during the period between 1 January 2012 and 31 December 2020. Of the 359 patients, 228 (63.51%) had eosinopenia. The proportion of patients with mild type disease was significantly lower in the eosinopenia group than in the noneosinopenia group (50.44% vs. 65.65%, P=0.006). The proportion of the patients with common type disease was significantly higher in the eosinopenia group than in the noneosinopenia group (39.47% vs. 28.24%, P=0.039).The proportion of the patients with severe type disease was higher in the eosinopenia group, although the difference did not reach statistical significance (10.09% vs. 6.11%, P = 0.243).

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“…Techniques with single cell resolution are required to uncover the contributions of individual clones to the polyclonal ASC pool, the prevalence of specific groups of ASC, and the relationships between the factors and markers that differentiate ASC. It should be noted that many other soluble effectors besides antibodies are also known to be secreted from ASC (12,13), including various interleukins and transforming growth factor-beta one (TGF-b1), and HT functional assays may also be readily adapted to study the role of these soluble factors.…”

Section: Functional Analysesmentioning

confidence: 99%

Single-Cell Technologies for the Study of Antibody-Secreting Cells

Broketa

Bruhns

2022

Front. Immunol.

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Antibody-secreting cells (ASC), plasmablasts and plasma cells, are terminally differentiated B cells responsible for large-scale production and secretion of antibodies. ASC are derived from activated B cells, which may differentiate extrafollicularly or form germinal center (GC) reactions within secondary lymphoid organs. ASC therefore consist of short-lived, poorly matured plasmablasts that generally secrete lower-affinity antibodies, or long-lived, highly matured plasma cells that generally secrete higher-affinity antibodies. The ASC population is responsible for producing an immediate humoral B cell response, the polyclonal antibody repertoire, as well as in parallel building effective humoral memory and immunity, or potentially driving pathology in the case of autoimmunity. ASC are phenotypically and transcriptionally distinct from other B cells and further distinguishable by morphology, varied lifespans, and anatomical localization. Single cell analyses are required to interrogate the functional and transcriptional diversity of ASC and their secreted antibody repertoire and understand the contribution of individual ASC responses to the polyclonal humoral response. Here we summarize the current and emerging functional and molecular techniques for high-throughput characterization of ASC with single cell resolution, including flow and mass cytometry, spot-based and microfluidic-based assays, focusing on functional approaches of the secreted antibodies: specificity, affinity, and secretion rate.

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Antibody-independent functions of B cells during viral infections

Cited by 44 publications

References 99 publications

Age-associated B cells in viral infection

Age-associated B cells in viral infection

Predictive role of blood eosinophils in adult varicella patients

Single-Cell Technologies for the Study of Antibody-Secreting Cells

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