Antibody Formation in Transfusion Therapy

Passwater, Michael

doi:10.1097/nan.0000000000000264

Cited by 5 publications

(4 citation statements)

References 18 publications

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“…More importantly, the immune response is closely associated with transfusion therapy (Passwater, 2018). Landers et al (1996) showed the immunomodulatory effects of blood transfusion in 1996.…”

Section: Introductionmentioning

confidence: 99%

The Immune System in Transfusion-Related Acute Lung Injury Prevention and Therapy: Update and Perspective

Guo

S.K.

2021

Front. Mol. Biosci.

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As an initiator of respiratory distress, transfusion-related acute lung injury (TRALI) is regarded as one of the rare complications associated with transfusion medicine. However, to date, the pathogenesis of TRALI is still unclear, and specific therapies are unavailable. Understanding the mechanisms of TRALI may promote the design of preventive and therapeutic strategies. The immune system plays vital roles in reproduction, development and homeostasis. Sterile tissue damage, such as physical trauma, ischemia, or reperfusion injury, induces an inflammatory reaction that results in wound healing and regenerative mechanisms. In other words, in addition to protecting against pathogens, the immune response may be strongly associated with TRALI prevention and treatment through a variety of immunomodulatory strategies to inhibit excessive immune system activation. Immunotherapy based on immune cells or immunological targets may eradicate complications. For example, IL-10 therapy is a promising therapeutic strategy to explore further. This review will focus on ultramodern advances in our understanding of the potential role of the immune system in TRALI prevention and treatment.

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Section: Introductionmentioning

confidence: 99%

The Immune System in Transfusion-Related Acute Lung Injury Prevention and Therapy: Update and Perspective

Guo

S.K.

2021

Front. Mol. Biosci.

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“…Blood transfusions save lives every day and have become an indispensable part of clinical practice in modern medicine. However, there have always been numerous limitations and problems with their use, namely dependence on donor readiness, short shelf life [ 1 ], risk of infection [ 2 ], transfusion reactions in the case of non-blood group-specific transfusion [ 3 ], immunization with the formation of antibodies [ 4 ], and an overall high personnel and financial expense [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Recognition mechanisms of hemoglobin particles by monocytes – CD163 may just be one

Nimz,

Rerkshanandana,

Kloypan

et al. 2023

Beilstein J. Nanotechnol.

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Hemoglobin-based oxygen carriers (HBOCs) as blood substitutes are one of the great hopes of modern transfusion and emergency medicine. After the major safety-relevant challenges of the last decades seem to be largely overcome, current developments have in common that they are affected by degradation and excretion at an early stage in test organisms. Several possible mechanisms that may be responsible for this are discussed in the literature. One of them is CD163, the receptor of the complex of haptoglobin (Hp) and hemoglobin (Hb). The receptor has been shown in various studies to have a direct affinity for Hb in the absence of Hp. Thus, it seems reasonable that CD163 could possibly also bind Hb within HBOCs and cause phagocytosis of the particles. In this work we investigated the role of CD163 in the uptake of our hemoglobin sub-micron particles (HbMPs) in monocytes and additionally screened for alternative ways of particle recognition by monocytes. In our experiments, blockade of CD163 by specific monoclonal antibodies proved to partly inhibit HbMP uptake by monocytes. It appears, however, that several other phagocytosis pathways for HbMPs might exist, independent of CD163 and also Hb.

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“…In addition, the immune response is a critical factor in transfusion therapy ( 9 ), as demonstrated by Landers et al in 1996, who showed blood transfusion-related immunomodulatory impacts ( 10 ). These responses are crucial for TRALI development ( 10 ), which involves recruiting inflammatory cells, producing proinflammatory factors, elevating reactive oxygen species levels, dysregulation of proteases, and impairment of the alveolar epithelium-capillary barrier ( 9 , 10 ).…”

Section: Introductionmentioning

confidence: 99%

The Alarmin Effect of Hmgb1/Rip3 on Transfusion-Related Acute Lung Injury via Tlr4/Nf-Κb or Mapk Pathway

Liu

Lin

Zhang

et al. 2023

Shock

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Non-antibody-mediated transfusion-related acute lung injury (TRALI) may account for up to 25% of TRALI cases. This indicates the need for further research to understand the pathophysiological mechanisms involved beyond antibody mediation fully. During this research, a TRALI rat model was developed using the trauma-blood loss-massive transfusion method. The severity of pulmonary edema was checked via measurement of lung histopathological changes and the amount of Evans blue dye fluid and bronchoalveolar lavage fluid protein leakage. In addition, potential mechanisms of pathophysiological pathways and inflammation cascades were investigated in TRALI rats in vivo. The findings indicated that TRALI increased inflammatory cytokines and triggered elevated levels of high-mobility group box 1(HMGB1)/ receptor-interacting protein kinase 3 (RIP3), apoptosis protein, and mRNAs in the TM (TRALI Model) group as opposed to the normal control.Furthermore, TRALI activated the Toll-like receptor 4 (TLR4) / Nuclear Factor-Kappa B (NF-κB) and mitogen-activated protein kinase (MAPK)signaling pathways, which partially regulated the inflammatory response in the TRALI rats. A significant increase was observed in the inflammatory mediators HMGB1 and RIP3 during the early stages of TRALI, suggesting that these mediators could be used as diagnostic markers for TRALI. In addition, HMGB1 and RIP3 promoted the inflammatory response by stimulating the TLR4/NF-κB and MAPK signaling pathways in the lung tissue of rats. Identifying efficient agents from inflammatory mediators such as alarmin can be an innovative scheme for diagnosing and preventing TRALI. These findings give HMGB1 and RIP3 a strong theoretical and experimental foundation for clinical use.

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Antibody Formation in Transfusion Therapy

Cited by 5 publications

References 18 publications

The Immune System in Transfusion-Related Acute Lung Injury Prevention and Therapy: Update and Perspective

The Immune System in Transfusion-Related Acute Lung Injury Prevention and Therapy: Update and Perspective

Recognition mechanisms of hemoglobin particles by monocytes – CD163 may just be one

The Alarmin Effect of Hmgb1/Rip3 on Transfusion-Related Acute Lung Injury via Tlr4/Nf-Κb or Mapk Pathway

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