Antibodies against the cytoplasm of human epidermal cells

Bystryn, Jean‐Claude

doi:10.1001/archderm.108.2.241

Cited by 21 publications

(9 citation statements)

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“…These proteins comigrated with keratins defined by specific anti-keratin monoclonal antibodies {data not shown). The presence, however, of these antibodies and their association with keratins has been shown to occur in a number of skin disorders, as well as in normal individuals [25,[44][45]. Therefore, the detection of such antibodies in only two of the five sera tested is considered unspecific and not related to the disease.…”

Section: Discussionmentioning

confidence: 99%

Toxic epidermal necrolysis: a study of 22 cases

Ioannides

Vakali

Chrysomallis

et al. 1994

Acad Dermatol Venereol

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Toxic epidermal necrolysis leads to extensive exfoliative epidermal slough, fever, systemic toxic reactions, conjunctivitis and severe mueous membrane involvement. As it evolves many other organs can be affected. Whether or not toxic epidermal necrolysis is the most severe form of erythema multiform is still a subject of discussion. The pathophysiological events involved are not well understood. Indirect evidence suggests a hyperscnsitivity reaction, but the search for potential immunoiogical mechanisms has resulted in little data to support this hypothesis. Drug reactions remain the most common associated factor. Twenty-two patients, 3-84 years old, have been included in this retrospective study. In 15 patients, clinical evidence points to drugs as the most important cause of toxic epidermal necrolysis. Recent infections were implicated in three patients and ulcerative colitis and lymphoma in one case each. Symptomatic therapy included fluid replacement, nutritional support and local treatment. Steroids were administered in 13 patients, followed by plasmapheresis in three. The mortality rate was approximately 27%. Elderly patients and patients with extensive lesions were at greater risk. Results of immunofluorescence and immunoblot analysis were of no significant interest.

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Section: Discussionmentioning

confidence: 99%

Toxic epidermal necrolysis: a study of 22 cases

Ioannides

Vakali

Chrysomallis

et al. 1994

Acad Dermatol Venereol

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“…Lehner as well as Donatsky and Dabelsteen found specific localization in the intracytoplasmic region of the prickle cell layer. It is worth noting, firstly, that this is not the site of the epithelial damage in the early lesion of RAU, and secondly, that there is evidence from other sources that circulating autoantibodies such as these can be the result of epithelial cell damage rather than its cause (Bystryn et al 1973). It is possible that the antibodies represent a cross-reaction between antigens of an organism, such as Streptococcus sanguis, and oral mucous membrane epithelial cells.…”

Section: Reeurrent Aphthous Ulceration (Aphthous Stomatitis)mentioning

confidence: 99%

Infections and non‐neoplastic diseases of the oral mucosa

1983

J Oral Pathology Medicine

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“…Indirect immunofluorescence was used to test sera for IC antibodies. The tests were performed by a standard technique (11), as previously described (24). Briefly, 0.2 ml of the appropriate dilution of human serum in PBS was incubated for 30 min at 27°C with cryostat-cut sections of frozen normal allogeneic skin and monkey and guinea pig esophagus.…”

Section: Introductionmentioning

confidence: 99%