Antibiotics in dust originating from a pig-fattening farm: a new source of health hazard for farmers?

Hamscher, Gerd; Pawelzick, Heike Theresia; Sczesny, Silke; Nau, Heinz; Hartung, J.

doi:10.1289/ehp.6288

Cited by 185 publications

(120 citation statements)

References 19 publications

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“…Tetracycline has been found in swine manure, soil fertilized with feces, sewage, sewage sludge, surface waters and even in drinking water (Domínguez et al, 2014). Different amounts of tetracycline have been determined in soil: 5 mg kg -1 (Hamscher et al, 2003) and 98.2 mg kg -1 (Chen et al, 2012). The applied doses of tetracycline are comparable to their actual/determined concentrations in the soil environment.…”

Section: Discussionmentioning

confidence: 97%

Tetracycline Accumulation in Pea Seedlings and its Effects on Proteome and Enzyme Activities

Margas¹,

Piotrowicz-Cieślak

Ziółkowska³

et al. 2016

IJAB

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To cite this paper: Margas, M., A.I. Piotrowicz-Cieślak, A. Ziółkowska and B. Adomas, 2016. Tetracycline accumulation in pea seedlings and its effects on proteome and enzyme activities. AbstractAmong antibiotics, tetracyclines are the most commonly used and detected in the environment. In this study, the amount of tetracycline taken up from soil by pea seedlings was analyzed, identified its main site of accumulation in plants and determined also changes in the protein profile of pea. The study demonstrates that pea seedlings take up tetracycline from soil and transport the drug via roots to over-ground parts and then accumulate it in the youngest parts, such as upper stem and leaves. After the taken up of drug, the activity of guaiacol peroxidase is modified and changes in the profile of proteins, as determined by two-dimensional gel electrophoresis occur. The majority of proteins (∼40%) visualized possessed molecular weight between 25 and 37 kDa. Only 8% of the proteins had molecular weight lower than 20 kDa, and 2% greater than 75 kDa. The number of spots in the control samples was 194, which is less by 49 than at the concentration of 150 mg kg -1 of soil. Isoflavone reductase was present only in seedlings growing with tetracycline. Tetracycline uptake from soil modify mainly the changes in biochemical processes connected with protein.

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Section: Discussionmentioning

confidence: 97%

Tetracycline Accumulation in Pea Seedlings and its Effects on Proteome and Enzyme Activities

Margas¹,

Piotrowicz-Cieślak

Ziółkowska³

et al. 2016

IJAB

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“…Δείγματα σκόνης που συλ λέχθηκαν από ένα χοιροστάσιο σε χρονικό διάστημα δυο δεκαετιών εξετάστηκαν για την παρουσία κατά λοιπων αντιβιοτικών και στο 90% των δειγμάτων ανι χνεύθηκαν τα αντιβιοτικά τυλοσίνη, τετρακυκλινες, σουλφαμεθαζινη και χλωραμφενικόλη σε συνολική ποσότητα 12,5mg/kg σκόνης. Τα αποτελέσματα αυτά αποδεικνύουν ότι η σκόνη αποτελεί μια νέα οδό εισό δου των κτηνιατρικών φαρμάκων στο περιβάλλον με δυσμενή αποτελέσματα όχι μόνο για τα ζώα της εκμε τάλλευσης, αλλά και για την υγεία των εργαζομένων στις κτηνοτροφικές μονάδες (Hamscher et al 2003).…”

Section: είσοδος και τύχη των φαρμάκων στο περιβάλλονunclassified

Drugs and environment

Tyrpenou¹

2017

J Hellenic Vet Med Soc

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ABSTRACT. Medicines are very important for the treatment and prevention of disease in both humans and animals, but at the same time they may have and several unintended effects with adverse results to the environmental organisms. Although these effects of the drugs on human and animal have been studied and still are investigated from the safety point of view with toxicological studies, the potential environmental impacts of their manufacture and use are not absolutely defined and well understood. That is why during the last years this issue has become of first priority and of increased research concern, although some results of several chemical groups, specifically some anthelminthics and antibiotics, are known. But, there are many other groups of substances that can actively affect the organisms in the environment. This is further complicated by the fact that some pharmaceuticals can show adverse effects on bacteria and animals at concentrations well below of those that are usually used in safety and efficacy experimental tests. In addition, breakdown products, metabolism and the combination of different biologically active compounds may have unanticipated effects on the environment. Although it may be safe to assume that these substances do not harm humans, recent research has started to determine whether and how they affect the organisms in the environment and what this means for environmental health and our health too. Pharmaceuticals have been released into the environment for decades, but researchers have only recently begun to determine their concentration levels in the environment. Using information from different countries they have identified those pharmaceuticals that are most likely to be released into the environment. For example, data from the United Kingdom on annual usage of veterinary drugs was combined with information on administration routes, metabolism and eco toxicity to identify medicines that should be monitored in a national investigation programme. At the same time, similar programmes are performed for human medicines using information on annual usage, therapeutic dose along with predictive models. Although these studies are generally based on country-specific information, they still provide an indication of those substances that should be investigated at the international level. It is of special importance the contribution of the instrumental chemical analysis and the new analytical techniques, like high performance liquid chromatography coupled with mass spectrometry (LC/MS-MS), which have allowed us to develop a better understanding of how medicines behave in the environment as well as to determine their concentrations in several soils, surface waters, groundwaters and elsewhere. Once released into the environment, pharmaceuticals will be transported and distributed to air, water, soil or sediment depending on the influence of different physicochemical characteristics. The degree to which a pharmaceutical is transported into the environment primarilly depends on the sorption behaviou...

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“…Industrialisation of animal production may lead not only to greater animal-to-animal contact, but also to increasing animal-to-human contact, particularly when production facilities border urban areas (Murphy, 1998). Furthermore, Hamscher et al (2003) demonstrated that antibiotics can also be spread to the environment by dust. Besides environmental effects, there is concern whether the widespread use of antibiotics in animals exacerbates the rising incidence in human pathogens.…”

Section: The Problemmentioning

confidence: 99%

Sound Localisation in Practice: An Application in Localisation of Sick Animals in Commercial Piggeries

Exadaktylos¹,

Silva²,

Ferrari³

et al. 2011

Advances in Sound Localization

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Antibiotics in dust originating from a pig-fattening farm: a new source of health hazard for farmers?

Cited by 185 publications

References 19 publications

Tetracycline Accumulation in Pea Seedlings and its Effects on Proteome and Enzyme Activities

Tetracycline Accumulation in Pea Seedlings and its Effects on Proteome and Enzyme Activities

Drugs and environment

Sound Localisation in Practice: An Application in Localisation of Sick Animals in Commercial Piggeries

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