Antibiotics for ureaplasma in the vagina in pregnancy

Abstract

There is insufficient evidence to assess whether pregnant women who have vaginal colonisation with ureaplasma should be treated with antibiotics to prevent preterm birth.Preterm birth is a significant perinatal problem. Upper genital tract infections, including ureaplasmas, are suspected of playing a role in preterm birth and preterm rupture of the membranes. Antibiotics are used to treat women with preterm prelabour rupture of the membranes; this may result in prolongation of pregnancy and lowers the risks of maternal and neonatal infection. However, antibiotics may be beneficial earlier in pregnancy to eradicate potentially causative agents.

Treatment of vaginal candidiasis for the prevention of preterm birth: a systematic review and meta-analysis

“…Despite the interest in infection as a risk factor for preterm birth, we found only two trials (including a small pilot study) to contribute to this review. Perhaps as Candida is considered a vaginal commensal organism [ 13 ], the role of candidiasis in preterm birth has not been pursued with the same attention as bacterial vaginosis and other vaginal organisms [ 11 , 50 - 53 ]. However, it is also possible that some relevant studies that could change the finding of the meta-analysis in the direction of no association were missed as only controlled vocabulary search terms were used and the search was limited to published studies.…”

Treatment of vaginal candidiasis for the prevention of preterm birth: a systematic review and meta-analysis

“…Despite the interest in infection as a risk factor for preterm birth, we found only two trials (including a small pilot study) to contribute to this review. Perhaps as Candida is considered a vaginal commensal organism [ 13 ], the role of candidiasis in preterm birth has not been pursued with the same attention as bacterial vaginosis and other vaginal organisms [ 11 , 50 - 53 ]. However, it is also possible that some relevant studies that could change the finding of the meta-analysis in the direction of no association were missed as only controlled vocabulary search terms were used and the search was limited to published studies.…”

Ureaplasma and Mycoplasma Screening for Pregnant Individuals Who Are at High Risk for Preterm Birth

“…If Ureaplasma cervical culture was positive, we prescribed azithromycin for pregnant individuals and doxycycline for sexual partners ( Table 1 ). 16 If Mycoplasma cervical culture was positive, we prescribed clindamycin for pregnant individuals and doxycycline for sexual partners ( Table 1 ). If pregnant individuals received antibiotics, we obtained Ureaplasma cervical culture 4 weeks after the initial treatment and treated them again if the second cervical culture was positive.…”

Prevalence and Antibiotic Susceptibility of Mycoplasma hominis and Ureaplasma urealyticum in Pregnant Women

“… 15 Macrolides are often used empirically in pregnant women, 9 as several agents are teratogens, such as tetracyclines and fluoroquinolones, which are the drugs of choice. 16 17 There was no resistance to doxycycline, josamycin, or pristinamycin for two isolates of M. hominis ; however, they were all resistant to azithromycin, clarithromycin, and erythromycin. Most of the U. urealyticum isolates were susceptible to josamycin and pristinamycin.…”

Treatment of vaginal candidiasis for the prevention of preterm birth: a systematic review and meta-analysis

“…Despite the interest in infection as a risk factor for preterm birth, we found only two trials (including a small pilot study) to contribute to this review. Perhaps as Candida is considered a vaginal commensal organism [ 13 ], the role of candidiasis in preterm birth has not been pursued with the same attention as bacterial vaginosis and other vaginal organisms [ 11 , 50 - 53 ]. However, it is also possible that some relevant studies that could change the finding of the meta-analysis in the direction of no association were missed as only controlled vocabulary search terms were used and the search was limited to published studies.…”

Ureaplasma and Mycoplasma Screening for Pregnant Individuals Who Are at High Risk for Preterm Birth

“…If Ureaplasma cervical culture was positive, we prescribed azithromycin for pregnant individuals and doxycycline for sexual partners ( Table 1 ). 16 If Mycoplasma cervical culture was positive, we prescribed clindamycin for pregnant individuals and doxycycline for sexual partners ( Table 1 ). If pregnant individuals received antibiotics, we obtained Ureaplasma cervical culture 4 weeks after the initial treatment and treated them again if the second cervical culture was positive.…”

Prevalence and Antibiotic Susceptibility of Mycoplasma hominis and Ureaplasma urealyticum in Pregnant Women

“… 15 Macrolides are often used empirically in pregnant women, 9 as several agents are teratogens, such as tetracyclines and fluoroquinolones, which are the drugs of choice. 16 17 There was no resistance to doxycycline, josamycin, or pristinamycin for two isolates of M. hominis ; however, they were all resistant to azithromycin, clarithromycin, and erythromycin. Most of the U. urealyticum isolates were susceptible to josamycin and pristinamycin.…”

Treatment of vaginal candidiasis for the prevention of preterm birth: a systematic review and meta-analysis

“…Despite the interest in infection as a risk factor for preterm birth, we found only two trials (including a small pilot study) to contribute to this review. Perhaps as Candida is considered a vaginal commensal organism [ 13 ], the role of candidiasis in preterm birth has not been pursued with the same attention as bacterial vaginosis and other vaginal organisms [ 11 , 50 - 53 ]. However, it is also possible that some relevant studies that could change the finding of the meta-analysis in the direction of no association were missed as only controlled vocabulary search terms were used and the search was limited to published studies.…”

Ureaplasma and Mycoplasma Screening for Pregnant Individuals Who Are at High Risk for Preterm Birth

“…If Ureaplasma cervical culture was positive, we prescribed azithromycin for pregnant individuals and doxycycline for sexual partners ( Table 1 ). 16 If Mycoplasma cervical culture was positive, we prescribed clindamycin for pregnant individuals and doxycycline for sexual partners ( Table 1 ). If pregnant individuals received antibiotics, we obtained Ureaplasma cervical culture 4 weeks after the initial treatment and treated them again if the second cervical culture was positive.…”

Prevalence and Antibiotic Susceptibility of Mycoplasma hominis and Ureaplasma urealyticum in Pregnant Women

“… 15 Macrolides are often used empirically in pregnant women, 9 as several agents are teratogens, such as tetracyclines and fluoroquinolones, which are the drugs of choice. 16 17 There was no resistance to doxycycline, josamycin, or pristinamycin for two isolates of M. hominis ; however, they were all resistant to azithromycin, clarithromycin, and erythromycin. Most of the U. urealyticum isolates were susceptible to josamycin and pristinamycin.…”