Antibiotics for uncomplicated urinary tract infection in women

Thompson, Sarah; Yacomeni, Sarah; Townsend, Robert

doi:10.1002/psb.606

Cited by 4 publications

(4 citation statements)

References 7 publications

(10 reference statements)

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“…Portugal is one of the European countries with MRSA rates higher than 50% [36] which may explain the higher frequency of this bacterium in UTI at the community level relatively to other countries. Staphylococcus saprophyticus , according to the literature has been the second most common cause of uncomplicated UTI, causing 5-10% of the UTI, [40,41] but in this study S. saprophyticus was not among the most implicated bacteria in UTI.…”

Section: Discussioncontrasting

confidence: 56%

Frequency and antimicrobial resistance patterns of bacteria implicated in community urinary tract infections: a ten-year surveillance study (2000–2009)

Linhares

Raposo²,

Rodrigues³

et al. 2013

BMC Infect Dis

209

147

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BackgroundUrinary tract infection (UTI) is one of the most common infectious diseases at the community level. In order to assess the adequacy of the empirical therapy, the prevalence and the resistance pattern of the main bacteria responsible for UTI in the community (in Aveiro, Portugal) was evaluated throughout a ten-year period.MethodsIn this retrospective study, all urine samples from patients of the District of Aveiro, in ambulatory regime, collected at the Clinical Analysis Laboratory Avelab during the period 2000–2009 were analysed. Samples with more than 105 CFU/mL bacteria were considered positive and, for these samples, the bacteria were identified and the profile of antibiotic susceptibility was characterized.ResultsFrom the 155597 samples analysed, 18797 (12.1%) were positive for bacterial infection. UTI was more frequent in women (78.5%) and its incidence varied with age, affecting more the elderly patients (38.6%). Although E. coli was, as usual, the most common pathogen implicated in UTI, it were observed differences related to the other bacteria more implicated in UTI relatively to previous studies. The bacteria implicated in the UTI varied with the sex of the patient, being P. aeruginosa a more important cause of infection in men than in women. The incidence of the main bacteria changed over the study period (P. aeruginosa, Klebsiella spp and Providencia spp increased and Enterobacter spp decreased). Although E. coli was responsible for more than an half of UTI, its resistance to antibiotics was low when compared with other pathogens implicated in UTI, showing also the lowest percentage of multidrug resistant (MDR) isolates (17%). Bacteria isolated from females were less resistant than those isolated from males and this difference increased with the patient age.ConclusionsThe differences in sex and age must be taken into account at the moment of empirical prescription of antimicrobials. From the recommended antimicrobials by the European Association of Urology guidelines, the first line drugs (pivmecillinam and nitrofurantoin) and the alternative antibiotic amoxicillin-clavulanic acid (AMX-CLA) are appropriate to treat community-acquired UTI, but the fluoroquinolones should not be suitable to treat male infections and the trimethoprim-sulfamethoxazole (SXT) shall not be used in the treatment of UTI at this level.

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Section: Discussioncontrasting

confidence: 56%

Frequency and antimicrobial resistance patterns of bacteria implicated in community urinary tract infections: a ten-year surveillance study (2000–2009)

Linhares

Raposo²,

Rodrigues³

et al. 2013

BMC Infect Dis

209

147

View full text Add to dashboard Cite

show abstract

“…Portugal is one of the European countries with MRSA rates higher than 50% [36] which may explain the higher frequency of this bacterium in UTI at the community level relatively to other countries. Staphylococcus saprophyticus, according to the literature has been the second most common cause of uncomplicated UTI, causing 5-10% of the UTI, [40,41] but in this study S. saprophyticus was not among the most implicated bacteria in UTI. Although E. coli was the most common uropathogen in both sexes, its incidence was significantly higher in women (71.7%) than in men (58.5%).…”

Section: Discussioncontrasting

confidence: 59%

Extended-Spectrum β-Lactamase and Multidrug Resistance in Urinary Sepsis Patients Admitted to the Intensive Care Unit

Kim

Lee

et al. 2014

Korean J Crit Care Med

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Background: Urinary tract infection (UTI) is one of the most common infectious diseases at the community level. In order to assess the adequacy of the empirical therapy, the prevalence and the resistance pattern of the main bacteria responsible for UTI in the community (in Aveiro, Portugal) was evaluated throughout a ten-year period.Methods: In this retrospective study, all urine samples from patients of the District of Aveiro, in ambulatory regime, collected at the Clinical Analysis Laboratory Avelab during the period 2000-2009 were analysed. Samples with more than 10 5 CFU/mL bacteria were considered positive and, for these samples, the bacteria were identified and the profile of antibiotic susceptibility was characterized. Results: From the 155597 samples analysed, 18797 (12.1%) were positive for bacterial infection. UTI was more frequent in women (78.5%) and its incidence varied with age, affecting more the elderly patients (38.6%). Although E. coli was, as usual, the most common pathogen implicated in UTI, it were observed differences related to the other bacteria more implicated in UTI relatively to previous studies. The bacteria implicated in the UTI varied with the sex of the patient, being P. aeruginosa a more important cause of infection in men than in women. The incidence of the main bacteria changed over the study period (P. aeruginosa, Klebsiella spp and Providencia spp increased and Enterobacter spp decreased). Although E. coli was responsible for more than an half of UTI, its resistance to antibiotics was low when compared with other pathogens implicated in UTI, showing also the lowest percentage of multidrug resistant (MDR) isolates (17%). Bacteria isolated from females were less resistant than those isolated from males and this difference increased with the patient age.Conclusions: The differences in sex and age must be taken into account at the moment of empirical prescription of antimicrobials. From the recommended antimicrobials by the European Association of Urology guidelines, the first line drugs (pivmecillinam and nitrofurantoin) and the alternative antibiotic amoxicillin-clavulanic acid (AMX-CLA) are appropriate to treat community-acquired UTI, but the fluoroquinolones should not be suitable to treat male infections and the trimethoprim-sulfamethoxazole (SXT) shall not be used in the treatment of UTI at this level.

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“…The βlactam groups differ from each other by additional rings other than the β-lactam ring for instance; Double ring structure for carbapenem, thiazolidine ring for penicillin, cephem nucleus for cephalosporin, none for monobactam (Lima et al, 2020). Earlier β-lactam antibiotics were active mainly against Gram-positive bacteria, while the discovery of broad spectrum β-lactam antibiotics which are active against Gram-negative organisms has increased their usefulness (Thompson et al, 2010).…”

Section: β-Lactam Antimicrobial Agentsmentioning

confidence: 99%

Review on β-lactams resistance among Klebsiella pneumoniae and Escherichia Coli clinical isolates

El-Antrawy,

El-Lakany

2023

Delta University Scientific Journal

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Escherichia coli and Klebsiella pneumoniae are two important members of Enterobacteriaceae family. They are involved in sever community and hospital acquired infections such as urinary tract infections (UTIs), gastroenteritis, and pneumonia. Some of these diseases are associated with high mortality rates if not treated properly, so it is important to combat them with highly effective antibiotics. The most commonly used antimicrobial agents are beta-lactams such as penicillins, cephalosporins and other non-beta lactams such as aminoglycosides and quinolones. Extensive use of antimicrobials and disinfectants has promoted the rapid development of bacterial resistance. This bacterial resistance becomes a global health problem especially in developing countries. The increased rate of resistance towards different classes of antibiotics limits the treatment options for such infections. The antibacterial activity of some antimicrobial agents can be enhanced by the addition of new β-lactamase inhibitors. Further in vivo investigation is needed to confirm their therapeutic efficacy against local isolates.

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Antibiotics for uncomplicated urinary tract infection in women

Cited by 4 publications

References 7 publications

Frequency and antimicrobial resistance patterns of bacteria implicated in community urinary tract infections: a ten-year surveillance study (2000–2009)

Frequency and antimicrobial resistance patterns of bacteria implicated in community urinary tract infections: a ten-year surveillance study (2000–2009)

Extended-Spectrum β-Lactamase and Multidrug Resistance in Urinary Sepsis Patients Admitted to the Intensive Care Unit

Review on β-lactams resistance among Klebsiella pneumoniae and Escherichia Coli clinical isolates

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