Antibiotics for sore throat

Abstract

Analysis 01.01. Comparison 01 Antibiotics versus control for the treatment of sore throat: incidence of complications, Outcome 01 Incidence of acute rheumatic fever within two months. Rheumatic fever defined by clinical diagnosis Analysis 01.02. Comparison 01 Antibiotics versus control for the treatment of sore throat: incidence of complications, Outcome 02 Incidence of acute rheumatic fever within two months. Penicillin versus control. .. .. . Analysis 01.03. Comparison 01 Antibiotics versus control for the treatment of sore throat: incidence of complications, Outcome 03 Incidence of acute rheumatic fever within two months: early (pre-1975) versus late studies (post-1975) Analysis 01.04. Comparison 01 Antibiotics versus control for the treatment of sore throat: incidence of complications, Outcome 04 Incidence of otitis media within 14 days. Otitis media defined by clinical diagnosis. .. .. Analysis 01.05. Comparison 01 Antibiotics versus control for the treatment of sore throat: incidence of complications, Outcome 05 Incidence of otitis media within 14 days: early (pre-1975) versus late studies (post-1975). .. Analysis 01.06. Comparison 01 Antibiotics versus control for the treatment of sore throat: incidence of complications, Outcome 06 Incidence of sinusitis within 14 days. Sinusitis defined by clinical diagnosis. .. .. .. . Analysis 01.07. Comparison 01 Antibiotics versus control for the treatment of sore throat: incidence of complications, Outcome 07 Incidence of quinsy within two months. Quinsy defined by clinical diagnosis. .. .. .. Analysis 01.08. Comparison 01 Antibiotics versus control for the treatment of sore throat: incidence of complications, Outcome 08 Incidence of acute glomerulonephritis within one month.

Treatment outcomes of acute streptococcal tonsillitis according to antibiotic treatment. A retrospective analysis of 242,366 cases treated in the community

“…showed that prescriptions other than penicillin-V, including amoxicillin, were associated with a greater risk of re-consultations within four weeks [ 37 ]. While the rate of complications seen in our study are similar to rates described in previous studies [ 5 , 38–40 ], studies comparing complication rates with different antibiotic treatments are scarce and underpowered [ 10 ], and non-suppurative sequels were not described at all in these studies. Our search could not identify any studies supporting or contradicting our findings of reduced complications with amoxicillin treatment.…”

Treatment outcomes of acute streptococcal tonsillitis according to antibiotic treatment. A retrospective analysis of 242,366 cases treated in the community

“…showed that prescriptions other than penicillin-V, including amoxicillin, were associated with a greater risk of re-consultations within four weeks [ 37 ]. While the rate of complications seen in our study are similar to rates described in previous studies [ 5 , 38–40 ], studies comparing complication rates with different antibiotic treatments are scarce and underpowered [ 10 ], and non-suppurative sequels were not described at all in these studies. Our search could not identify any studies supporting or contradicting our findings of reduced complications with amoxicillin treatment.…”

Symptomatic treatment of uncomplicated lower urinary tract infections in the ambulatory setting: randomised, double blind trial

“…Accordingly, antibiotics are often withheld in cases of self limited, benign bacterial diseases such as acute otitis media, sinusitis, and traveller’s diarrhoea at the cost of a prolongation of symptoms by typically 1-3 days. 29 30 31 32 33 34 35 36 Our results in women with uncomplicated lower UTI are well in line with the prolongation of symptoms observed with symptomatic treatment of these conditions. As many women in the diclofenac group resorted to antibiotic treatment in our trial, a strategy of selectively deferring rather than completely withholding antibiotic treatment may be preferable for uncomplicated lower UTI.…”

Incidence and clinical variables associated with streptococcal throat infections: a prospective diagnostic cohort study

“…2,4,31 Historical comparisons tentatively suggest that these variables may identify a group of patients who are more likely to benefit from antibiotics. 1 The study confirmed the importance of cervical glands and the absence of a bad cough and of fever. 7,8 However, this study documents that although the feature of purulence is associated with the presence of group A streptococci in univariate analysis, in this data set it is not independently predictive -and other features may be important, particularly the severity of both the sore throat and the inflammation, the prior duration (reflecting the more rapid severe onset), muscle aches, and possibly the absence of coryza.…”

Treatment outcomes of acute streptococcal tonsillitis according to antibiotic treatment. A retrospective analysis of 242,366 cases treated in the community

“…showed that prescriptions other than penicillin-V, including amoxicillin, were associated with a greater risk of re-consultations within four weeks [ 37 ]. While the rate of complications seen in our study are similar to rates described in previous studies [ 5 , 38–40 ], studies comparing complication rates with different antibiotic treatments are scarce and underpowered [ 10 ], and non-suppurative sequels were not described at all in these studies. Our search could not identify any studies supporting or contradicting our findings of reduced complications with amoxicillin treatment.…”

Symptomatic treatment of uncomplicated lower urinary tract infections in the ambulatory setting: randomised, double blind trial

“…Accordingly, antibiotics are often withheld in cases of self limited, benign bacterial diseases such as acute otitis media, sinusitis, and traveller’s diarrhoea at the cost of a prolongation of symptoms by typically 1-3 days. 29 30 31 32 33 34 35 36 Our results in women with uncomplicated lower UTI are well in line with the prolongation of symptoms observed with symptomatic treatment of these conditions. As many women in the diclofenac group resorted to antibiotic treatment in our trial, a strategy of selectively deferring rather than completely withholding antibiotic treatment may be preferable for uncomplicated lower UTI.…”

Incidence and clinical variables associated with streptococcal throat infections: a prospective diagnostic cohort study

“…2,4,31 Historical comparisons tentatively suggest that these variables may identify a group of patients who are more likely to benefit from antibiotics. 1 The study confirmed the importance of cervical glands and the absence of a bad cough and of fever. 7,8 However, this study documents that although the feature of purulence is associated with the presence of group A streptococci in univariate analysis, in this data set it is not independently predictive -and other features may be important, particularly the severity of both the sore throat and the inflammation, the prior duration (reflecting the more rapid severe onset), muscle aches, and possibly the absence of coryza.…”

Treatment outcomes of acute streptococcal tonsillitis according to antibiotic treatment. A retrospective analysis of 242,366 cases treated in the community

“…showed that prescriptions other than penicillin-V, including amoxicillin, were associated with a greater risk of re-consultations within four weeks [ 37 ]. While the rate of complications seen in our study are similar to rates described in previous studies [ 5 , 38–40 ], studies comparing complication rates with different antibiotic treatments are scarce and underpowered [ 10 ], and non-suppurative sequels were not described at all in these studies. Our search could not identify any studies supporting or contradicting our findings of reduced complications with amoxicillin treatment.…”

Symptomatic treatment of uncomplicated lower urinary tract infections in the ambulatory setting: randomised, double blind trial

“…Accordingly, antibiotics are often withheld in cases of self limited, benign bacterial diseases such as acute otitis media, sinusitis, and traveller’s diarrhoea at the cost of a prolongation of symptoms by typically 1-3 days. 29 30 31 32 33 34 35 36 Our results in women with uncomplicated lower UTI are well in line with the prolongation of symptoms observed with symptomatic treatment of these conditions. As many women in the diclofenac group resorted to antibiotic treatment in our trial, a strategy of selectively deferring rather than completely withholding antibiotic treatment may be preferable for uncomplicated lower UTI.…”

Incidence and clinical variables associated with streptococcal throat infections: a prospective diagnostic cohort study

“…2,4,31 Historical comparisons tentatively suggest that these variables may identify a group of patients who are more likely to benefit from antibiotics. 1 The study confirmed the importance of cervical glands and the absence of a bad cough and of fever. 7,8 However, this study documents that although the feature of purulence is associated with the presence of group A streptococci in univariate analysis, in this data set it is not independently predictive -and other features may be important, particularly the severity of both the sore throat and the inflammation, the prior duration (reflecting the more rapid severe onset), muscle aches, and possibly the absence of coryza.…”