Antibiotics Combinations and Chitosan Nanoparticles for Combating Multidrug Resistance Acinetobacter baumannii

Banoub, Nancy G; Saleh, Sarra E.; Helal, Hala S; Aboshanab, Khaled M.

doi:10.2147/idr.s328788

Cited by 15 publications

(8 citation statements)

References 76 publications

(113 reference statements)

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“…The samples were grown in blood agar, TSB, MacConkey, and Simmons citrate agar cultures at 37 °C for 24 h. Gram staining, catalase, oxidase, urease, and lysine decarboxylase tests verified the detection of Staphylococcus aureus isolates. Based on the CLSI (Clinical and Laboratory Standards Institute, 2019) protocol, the Kirby‐Bauer disc diffusion method was used to evaluate antibiotic susceptibility [45] . Muller Hinton agar culture was used to assess the sensitivity of Staphylococcus aureus isolates to imipenem (IMI, 10 g), methicillin (MET, 10 g), ciprofloxacin (CIP, 5 g), vancomycin (VA, 10 g), erythromycin (E, 15 g), chloramphenicol (C, 30 g), amikacin (AK, 10), clindamycin (CD, 2 μg), kanamycin (KAN, 30 μg), ceftazidime (CAZ, 30 μg) and colistin (CS, 5 μg) and), tetracycline (TE, 30 μg) (MAST, UK) disks.…”

Section: Methodsmentioning

confidence: 99%

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confidence: 99%

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Designing Alginate/Chitosan Nanoparticles Containing Echinacea angustifolia: A Novel Candidate for Combating Multidrug‐Resistant Staphylococcus aureus

Taghiloo

Ghajari

Zand

et al. 2023

Chemistry & Biodiversity

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Nanoparticles (NPs) may help treat multidrug-resistant Staphylococcus aureus (MDR). This study prepared and evaluated chitosan/alginate-encapsulated Echinacea angustifolia extract against MDR strains. Evaluating synthesized NPs with SEM, DLS, and FT-IR. Congo red agar and colorimetric plate techniques examined isolate biofilm formation. NP antibacterial power was assessed using well diffusion. Real-time PCR assessed biofilmforming genes. MTT assessed the synthesized NPs' toxicity. According to DLS measurements, spherical E. angustifolia NPs had a diameter of 335.3 � 1.43 nm. The PDI was 0.681, and the entrapment effectiveness (EE%) of the E. angustifolia extract reached 83.45 %. Synthesized NPs were most antimicrobial. S. aureus resistant to several treatments was 80 percent of 100 clinical samples. Biofilm production was linked to MDR in all strains. The ALG/CS-encapsulated extract had a 4 to 32-fold lower MIC than the free extract, which had no bactericidal action. They also significantly decreased the expression of genes involved in biofilm formation. E. angustifolia-encapsulated ALG/CS decreased IcaD, IcaA, and IcaC gene expression in all MDR strains (***p < 0.001). Free extract, free NPs, and E. angustifolia-NPs had 57.5 %, 85.5 %, and 90.0 % cell viability at 256 μg/ml. These discoveries could assist generate stable plant extracts by releasing natural-derived substances under controlled conditions.

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Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

Designing Alginate/Chitosan Nanoparticles Containing Echinacea angustifolia: A Novel Candidate for Combating Multidrug‐Resistant Staphylococcus aureus

Taghiloo

Ghajari

Zand

et al. 2023

Chemistry & Biodiversity

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“…Thus, they will kill useful microbes along with their target microbes. Therefore, the enhancement of the antibacterial capacity can be achieved by combining photocatalysts with a bacterial targeting strategy including nanocarriers, aptamers, antibodies, bacteriophages, etc. − …”

Section: Design Strategies For Improving Photocatalytic Performancementioning

confidence: 99%

Photocatalytic Antimicrobials: Principles, Design Strategies, and Applications

Ran,

Wang

et al. 2023

Chem. Rev.

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Nowadays, the increasing emergence of antibiotic-resistant pathogenic microorganisms requires the search for alternative methods that do not cause drug resistance. Phototherapy strategies (PTs) based on the photoresponsive materials have become a new trend in the inactivation of pathogenic microorganisms due to their spatiotemporal controllability and negligible side effects. Among those phototherapy strategies, photocatalytic antimicrobial therapy (PCAT) has emerged as an effective and promising antimicrobial strategy in recent years. In the process of photocatalytic treatment, photocatalytic materials are excited by different wavelengths of lights to produce reactive oxygen species (ROS) or other toxic species for the killing of various pathogenic microbes, such as bacteria, viruses, fungi, parasites, and algae. Therefore, this review timely summarizes the latest progress in the PCAT field, with emphasis on the development of various photocatalytic antimicrobials (PCAMs), the underlying antimicrobial mechanisms, the design strategies, and the multiple practical antimicrobial applications in local infections therapy, personal protective equipment, water purification, antimicrobial coatings, wound dressings, food safety, antibacterial textiles, and air purification. Meanwhile, we also present the challenges and perspectives of widespread practical implementation of PCAT as antimicrobial therapeutics. We hope that as a result of this review, PCAT will flourish and become an effective weapon against pathogenic microorganisms and antibiotic resistance.

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“…A preclinical analysis of bupivacaine-loaded CNPs revealed the enhanced anesthetic outcome of the payload following infraorbital nerve blockade [ 102 ]. Antibiotics-loaded CNPs were studied to combat multidrug resistance due to A. baumannii from clinical isolates of AL Kasr Al Aini hospital, Cairo, Egypt [ 105 ]. Similarly, ketorolac tromethamine-loaded CNPs were implemented for managing the local inflammatory process in the postoperative stage after the surgical removal of warts [ 106 ].…”

Section: Clinical Manifestation Of Cnps Against Infectious Diseasesmentioning

confidence: 99%

A clinical perspective of chitosan nanoparticles for infectious disease management

2023

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Antibiotics Combinations and Chitosan Nanoparticles for Combating Multidrug Resistance Acinetobacter baumannii

Cited by 15 publications

References 76 publications

Designing Alginate/Chitosan Nanoparticles Containing Echinacea angustifolia: A Novel Candidate for Combating Multidrug‐Resistant Staphylococcus aureus

Designing Alginate/Chitosan Nanoparticles Containing Echinacea angustifolia: A Novel Candidate for Combating Multidrug‐Resistant Staphylococcus aureus

Photocatalytic Antimicrobials: Principles, Design Strategies, and Applications

A clinical perspective of chitosan nanoparticles for infectious disease management

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