Antibiotics against viruses: Brazilian doctors adrift

Silva, Heslley Machado

doi:10.1017/ice.2021.434

Cited by 8 publications

(6 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another potential use of this plant comes from the popular perception that it is a forest antibiotic, with great potential for fighting bacteria 34 and fungi 35 . This approach to fighting bacteria can open up a space for the classroom to be a place of alert about the misuse of antibiotics, which increased a lot in Brazil during the COVID-19 pandemic, due to misinformation on the Internet and social networks, even by doctors 36 , reverberating in the increase of bacterial resistance 37 . It is necessary that students and society are aware of the consequences of this procedure, with the difficulty of fighting bacterial infections, and the increase in morbidity and mortality.…”

Section: The Valuable Foods We Inherited From the Indigenous Peoplementioning

confidence: 99%

Indigenous Culture: What can we learn (and teach)?

Silva

2023

Sym. Bio. Ed.

View full text Add to dashboard Cite

Valuing the culture of the native people of a country is always relevant, and science and biology classes can become an interesting space for this appreciation. It is suggested that cultural, behavioral, and social aspects inherited from the indigenous people in Brazil be used as didactic learning tools. It is demonstrated that knowledge related to the preservation of the Amazon Rainforest, hygiene, food, and medications, already present in different scales in Brazilian daily life, has its origin in knowledge from the native peoples of Brazil, although this origin is little known and publicized. It is noteworthy that these topics can be used in a multidisciplinary way so that students can perceive the acquisition in a broader way and interrelated to their daily lives. It is important not to miss any opportunity to increase scientific literacy in the classroom and the knowledge bequeathed by the Indians has potential for this learning. Finally, it is suggested to use the lessons to alert and confront the issue of scientific fake news through the internet and social media.

show abstract

Section: The Valuable Foods We Inherited From the Indigenous Peoplementioning

confidence: 99%

Indigenous Culture: What can we learn (and teach)?

Silva

2023

Sym. Bio. Ed.

View full text Add to dashboard Cite

show abstract

“…Fortunately, against the indications contrary to the vaccines of the president, and unbelievably, even some doctors [8], Brazilians did not opt for the drugs without effectiveness, such as chloroquine and similar. The people of Brazil started to take the available vaccines, the immunization of the population was regularized, changing this scenario in the second half of 2021, improving the prospects of the pandemic picture.…”

Section: Review Articlementioning

confidence: 99%

Brazil and the (Un)Natural Selection of SARS-CoV-2

Silva¹

2022

Ann Public Health Reports

View full text Add to dashboard Cite

“…Antibiotics are no solutions to rescue human beings from viruses ( 13 ) although some antiviral drugs are available for the cure. Food and Drug Administration (FDA) has approved mostly small molecules and some large molecules such as oligonucleotides, interferons, and monoclonal antibodies against viral infections ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

The potential of IFN-λ, IL-32γ, IL-6, and IL-22 as safeguards against human viruses: a systematic review and a meta-analysis

Sattar,

Qaiser,

Kausar

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

Many studies have investigated the antiviral activity of cytokines, including interleukin-6 (IL-6), interleukin-22 (IL-22), interleukin-32 gamma (IL-32γ), and interferon-lambda (IFN-λ) in diverse populations. This study aims to evaluate the role of these cytokines in inhibition of various human and animal viruses when administered exogenously. A comprehensive meta-analysis and systematic review were conducted on all the relevant studies from three databases. Standard mean differences (SMDs) of overall viral inhibition were used to generate the difference in the antiviral efficacy of these cytokines between control and experimental groups. A total of 4,618 abstracts for IL-6, 3,517 abstracts for IL-22, 2,160 abstracts for IL-32γ, and 1,026 abstracts for IFN-λ were identified, and 7, 4, 8, and 35 studies were included, respectively, for each cytokine. IFN-λ (SMD = 0.9540; 95% CI: 0.69–0.22) and IL-32γ (SMD = 0.459; 95% CI: 0.02–0.90) showed the highest influence followed by IL-6 (SMD = 0.456; CI: −0.04–0.95) and IL-22 (SMD = 0.244; 95% CI: −0.33–0.81). None of the cytokines represented heterogeneity (tau² > 0), but only IFN-λ indicated the funnel plot asymmetry (p = 0.0097). Results also indicated that IFN-λ and IL-32γ are more potent antivirals than IL-6 and IL-22. The collective findings of this study emphasize that exogenously administered pro-inflammatory cytokines, specifically IFN-λ and IL-32, exhibit a significant antiviral activity, thereby underscoring them as potent antiviral agents. Nonetheless, additional research is required to ascertain their clinical utility and potential for integration into combinatorial therapeutic regimens against viral infections.

show abstract

Antibiotics against viruses: Brazilian doctors adrift

Cited by 8 publications

References 10 publications

Indigenous Culture: What can we learn (and teach)?

Indigenous Culture: What can we learn (and teach)?

Brazil and the (Un)Natural Selection of SARS-CoV-2

The potential of IFN-λ, IL-32γ, IL-6, and IL-22 as safeguards against human viruses: a systematic review and a meta-analysis

Contact Info

Product

Resources

About