Antibiotic Susceptibility Profile and Occurrence of Escherichia coli Isolated from Clinical and Environmental Samples in Cape Coast, Ghana

Adinortey, Cynthia Ayefoumi; Amewowor, Dhak; Otwe, Emmanuel Plas; Galyuon, I.K.A.; Asante, D.K.A.

doi:10.3923/jm.2017.170.176

Cited by 4 publications

(3 citation statements)

References 13 publications

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“…In the case of urine samples, the antibiotic sensitivity profile showed that E. coli isolates were extremely sensitive to ertapenem and imipenem and highly resistant to ampicillin. This result is in agreement with previous studies showing that E. coli isolates from urine samples were highly resistant to ampicillin (5) and highly sensitive to imipenem (21). In another study conducted in Iraq, the majority of clinical E. coli isolates from urine samples were resistant to amoxicillin/clavulanic acid (3).…”

Section: Discussionsupporting

confidence: 92%

Antibiotic Susceptibility Pattern of Escherichia coli Isolated from Various Clinical Samples in Duhok City, Kurdistan Region of Iraq

et al. 2020

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Background: Escherichia coli (E. coli) is one of the most common causative agents of bacterial infections. The emergence of multidrug-resistant E. coli is a major public health threat worldwide. Objectives: This study aimed to determine the antibiotic susceptibility profile of clinical isolates of E. coli from different samples. Methods: A total number of 454 clinical samples, including urine, wound, cervical swab, blood, semen, ascetic, and cerebral spinal fluid samples were collected from patients between January 2017 and February 2020. Then, E. coli was confirmed and susceptibility to different antibiotics was determined using the Vitek-2 compact system. Results: Escherichia coli isolates were more frequent in females (70.7%) than in males (29.3%). In the case of urine samples, E. coli was found to be highly susceptible to ertapenem (97.6%) and imipenem (96.4%) but resistant to ampicillin (87.8%). For wound and cervical swabs, E. coli was 100% resistant to ampicillin and cefepime but 100% sensitive to ertapenem and imipenem. It was found that E. coli isolates from blood samples were 100% resistant to ampicillin, ceftriaxone, and cefoxitin, and around 75% of them were sensitive to ertapenem, ciprofloxacin, and levofloxacin. Finally, E. coli isolated from other clinical samples were highly sensitive to ertapenem, imipenem, levofloxacin, nitrofurantoin, and cefazolin. Conclusions: Escherichia coli isolated from various clinical specimens showed differences in antibiotic sensitivity patterns, with high resistance to commonly used antibiotics. The most effective antibiotics against E. coli isolates were ertapenem, imipenem, and nitrofurantoin. However, the clinical isolates of E. coli displayed high resistance rates to ampicillin, ceftriaxone, and cefepime. Therefore, it is proposed to perform antibiotic sensitivity testing by physicians to select the most effective antibiotics.

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Section: Discussionsupporting

confidence: 92%

Antibiotic Susceptibility Pattern of Escherichia coli Isolated from Various Clinical Samples in Duhok City, Kurdistan Region of Iraq

et al. 2020

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“…Based on the target in the bacterial cell, antibiotics can be divided into three groups: inhibitors of cell wall synthesis (ampicillin, cefuroxime, ceftriaxone, and cefotaxime), inhibitors of protein synthesis (gentamicin, tetracycline, and chloramphenicol), and inhibitors of metabolite synthesis (co-trimoxazole) [ 26 ]. As reported in other studies conducted in Ghana, the highest level of resistance was recorded for ampicillin in this study [ 16 , 42 , 45 ]. Ampicillin is a broad-spectrum penicillin that is active against many bacteria and has been used for a relatively long period.…”

Section: Discussionsupporting

confidence: 83%

Multiple Antibiotic Resistance-Coliform Bacteria in Some Selected Fish Farms of the Central Region of Ghana

et al. 2020

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This study aimed at assessing the quality of water and fishery products as well as the antibiotic resistance status of some selected fish farms of the Central Region of Ghana. Interview guides were administered to farmers to get data on farming practices and antibiotic use. Total coliform loads of catfish (Clarias gariepinus), tilapia (Oreochromis niloticus), and water samples were determined. Coliforms were identified through various biochemical assays, and their antibiotic resistance patterns were determined. Generally, the total coliform loads of water samples significantly surpassed those of fish samples p < 0.05 . The maximum and minimum antibiotic resistance percentages were recorded for ampicillin (96.83%) and gentamicin (6.35%), respectively. Although farmers stated that antibiotics were sparingly used, coliform bacteria isolated exhibited various antibiotic resistance patterns. Four out of six fish farms harboured some coliforms with multiple antibiotic resistance (MAR) indices above 0.2, an indication that these bacteria originated from potentially dangerous sources where antibiotics are regularly used.

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“…28 The presence of Shiga toxins producing Escherichia coli and Shigella spps in foods in Ghana indicates that such foods should be contaminated with the toxins. 29,88 Also, heat-stable toxin-producing Staphylococcus aureus is associated with several foods sold on the streets of Ghana and in restaurants. 30 The reports on the outbreak of Listeriosis in South Africa cautioned the Ghanaians and the government to put measures in place to prevent the outbreak of that disease in Ghana.…”

Section: Microbial Contamination Of Food Cases In Ghanamentioning

confidence: 99%

Food Safety in Sub-Sahara Africa, An insight into Ghana and Nigeria

Cudjoe

Balali

Titus

et al. 2022

Environ�Health�Insights

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Food safety is a global concern in today’s world, and harnessing food safety in Sub-Saharan Africa, especially Nigeria and Ghana are momentous. This review presents an insight into the situation of food safety in Nigeria and Ghana. Using a desktop review technique, research papers were evaluated to find major sources of food safety concerns. It was revealed that many studies reported on food contamination at the consumption level whereas few reported on the healthiness of the production chain. Improper handling of food at the local markets, vending sites hygiene practices of food vendors, and bad transportation and packing systems have all been implicated. Inadequate education is a major cause of food contamination, especially at the consumption level. Again, etiologic agents responsible for food-borne illness in Ghana and Nigeria range from viruses, fungi, parasites, and protozoans to bacteria. They include rotavirus, hepatitis A virus, Lassa fever (LHF), human noroviruses (HNoV), Aspergillus parasiticus, Aspergillus flavus, Aspergillus niger, Taenia solium, Ascaris spp., Toxoplasma gondii, Cryptosporidium spp. Enterobacter spp., Pseudomonas spp., Campylobacter spp., Escherichia coli. Staphylococcus spp., Salmonella spp., Vibrio cholerae and Listeria monocytogenes. Their toxins are responsible for numerous food contaminants. Some foods are contaminated with chemicals including pesticide residues, lead, mercury, etc. Laws of food safety are not well enforced leading to complications in the food production chain. Rigorous monitoring and evaluation coupled with surveillance and education to harness the situation and detect issues that compromise the right process is a necessity. Finally, intentional enforcement of regulations by regulatory agencies will go a long way to curb food contamination and food-borne illnesses within the region.

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Antibiotic Susceptibility Profile and Occurrence of Escherichia coli Isolated from Clinical and Environmental Samples in Cape Coast, Ghana

Cited by 4 publications

References 13 publications

Antibiotic Susceptibility Pattern of Escherichia coli Isolated from Various Clinical Samples in Duhok City, Kurdistan Region of Iraq

Antibiotic Susceptibility Pattern of Escherichia coli Isolated from Various Clinical Samples in Duhok City, Kurdistan Region of Iraq

Multiple Antibiotic Resistance-Coliform Bacteria in Some Selected Fish Farms of the Central Region of Ghana

Food Safety in Sub-Sahara Africa, An insight into Ghana and Nigeria

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