Antibiotic-Resistant and Non-Resistant Bacteria Display Similar Susceptibility to Dielectric Barrier Discharge Plasma

Sakudo, Akikazu; Misawa, Tatsuya

doi:10.3390/ijms21176326

Cited by 21 publications

(10 citation statements)

References 33 publications

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“…It is also demonstrated that plasma multi jets can be a potent bactericidal agent for native or mature bacterial lawns contaminated with a single but also a mix of various pathogens. Similar efficiency was demonstrated for antibiotic-resistant and non-resistant P. aeruginosa (see Figure 9) as previously reported but for E. coli bacteria and with dielectric barrier discharge applicator [33]. This strengthens the well-known unique status of plasma technology in comparison with conventional antibiotic drugs, as a broad spectrum and non-systemic, and thus likely a low side-effect, therapeutic option.…”

Section: Discussionsupporting

confidence: 88%

“…Planktonic or biofilm growth on borosilicate slides cultured in 24-well plates were considered in this work, and a combination of plasma treatment with antibiotics was also evaluated. In [33], a dielectric barrier discharge (DBD) plasma torch generated with an air flow at 3.5 L/min and delivering a plasma jet 4 mm in diameter was used to study the sensitivity of antibiotic-resistant and non-resistant bacteria. The microorganisms were set in a thin liquid layer covering a glass substrate.…”

Section: Introductionmentioning

confidence: 99%

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Anti-Bacterial Action of Plasma Multi-Jets in the Context of Chronic Wound Healing

et al. 2021

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This work is a contribution to the development and implementation of non-thermal plasma technology for decontamination in the perspective of nosocomial and chronic wound innovative therapies. Multi jets devices based on Plasma Gun® technology in static and scanning operation modes and bacterial lawns inoculated with resistant and non-resistant bacterial strains were designed and used. A pilot toxicity study exploring plasma treatment of wound bearing patients, performed with a low voltage plasma applicator, is documented as a first step for the translation of in vitro experiments to clinical care. Bacterial inactivation was demonstrated for Staphylococcus aureus, Pseudomonas aeruginosa and drug resistant S. aureus, P. aeruginosa and Escherichia Coli strains collected from patient wounds at Orleans (France) hospital. A few square centimeter large contaminated samples were inactivated following a single plasma exposure as short as one minute. Samples inoculated with a single but also a mix of three resistant pathogens were successfully inactivated not only right after their contamination but for mature lawns as well. Similar bactericidal action was demonstrated for antibiotic-resistant and non-resistant P. aeruginosa. The time exposure dependent increase of the inhibition spots, following multi jets exposure, is discussed as either the accumulation of reactive species or the likely combinatory action of both the reactive species and transient electric field delivery on inoculated samples.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Anti-Bacterial Action of Plasma Multi-Jets in the Context of Chronic Wound Healing

et al. 2021

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“…Independent studies by the likes of Socransky et al. [ 44 ] amongst others have found that various types of bacteria like P. aeruginosa [ 45 ], Staphylococcus aureus [ 4 ], Escherichia Coli [ 4 , 46 ] , Enterococcus faecalis [ 47 ], can be inactivated by plasma, as mentioned in Table 2 .…”

Section: Application Of Ntp In Dentistrymentioning

confidence: 99%

Aurora Borealis in dentistry: The applications of cold plasma in biomedicine

Lata

Chakravorty

Mitra

et al. 2022

Materials Today Bio

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Plasma is regularly alluded to as the fourth form of matter. Its bounty presence in nature along with its potential antibacterial properties has made it a widely utilized disinfectant in clinical sciences. Thermal plasma and non-thermal (or cold atmospheric) plasma (NTP) are two types of plasma. Atoms and heavy particles are both available at the same temperature in thermal plasma. Cold atmospheric plasma (CAP) is intended to be non-thermal since its electrons are hotter than the heavier particles at ambient temperature. Direct barrier discharge (DBD), atmospheric plasma pressure jet (APPJ), etc. methods can be used to produce plasma, however, all follow a basic concept in their generation. This review focuses on the anticipated uses of cold atmospheric plasma in dentistry, such as its effectiveness in sterilizing dental instruments by eradicating bacteria, its advantage in dental cavity decontamination over conventional methods, root canal disinfection, its effects on tooth whitening, the benefits of plasma treatment on the success of dental implant placement, and so forth. Moreover, the limitations and probable solutions has also been anticipated. These conceivable outcomes thus have proclaimed the improvement of more up-to-date gadgets, for example, the plasma needle and plasma pen, which are efficient in treating the small areas like root canal bleaching, biofilm disruption, requiring treatment in dentistry.

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“…An air DBD-based indirect LTP source is shown in Fig. 1(c) [32]. A commercial version of this type of LTP is the PlasmaDerm device.…”

Section: Introductionmentioning

confidence: 99%

Low-Temperature Plasma for Biology, Hygiene, and Medicine: Perspective and Roadmap

Laroussi

Bekeschus

Keidar

et al. 2022

IEEE Trans. Radiat. Plasma Med. Sci.

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Plasma, the fourth and most pervasive state of matter in the visible universe, is a fascinating medium that is connected to the beginning of our universe itself. Man-made plasmas are at the core of many technological advances that include the fabrication of semiconductor devices, which enabled the modern computer and communication revolutions. The introduction of low temperature, atmospheric pressure plasmas to the biomedical field has ushered a new revolution in the healthcare arena that promises to introduce plasma-based therapies to combat some thorny and long-standing medical challenges. This article presents an overview of where research is at today and discusses innovative concepts and approaches to overcome present challenges and take the field to the next level. It is written by a team of experts who took an in-depth look at the various applications of plasma in hygiene, decontamination, and medicine, made critical analysis, and proposed ideas and concepts that should help the research community focus their efforts on clear and practical steps necessary to keep the field advancing for decades to come.

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Antibiotic-Resistant and Non-Resistant Bacteria Display Similar Susceptibility to Dielectric Barrier Discharge Plasma

Cited by 21 publications

References 33 publications

Anti-Bacterial Action of Plasma Multi-Jets in the Context of Chronic Wound Healing

Anti-Bacterial Action of Plasma Multi-Jets in the Context of Chronic Wound Healing

Aurora Borealis in dentistry: The applications of cold plasma in biomedicine

Low-Temperature Plasma for Biology, Hygiene, and Medicine: Perspective and Roadmap

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