Antibiotic regimens for management of intraamniotic infection

Abstract

Antibiotic regimens for management of intraamniotic infection.

A First Look at Chorioamnionitis Management Practice Variation among US Obstetricians

“…A 2002 Cochrane Database Review indicated that there are insufficient data on which to base a recommendation for optimal antibiotic regimens in the setting of chorioamnionitis [13]. Not surprisingly, our results demonstrate a wide variety of antibiotic regimens in common use.…”

“…Not surprisingly, our results demonstrate a wide variety of antibiotic regimens in common use. Most of these regimens contain sufficient Gram-negative coverage and consist of broad spectrum antibiotics that cover for beta-lactamase producing aerobes and anaerobes, as has been recommended by expert consensus and nonrandomized published studies [1–6, 9, 13–16, 22–27]. However, 15% of providers use ampicillin or cefazolin alone, regimens that do not contain Gram-negative coverage and are theoretically insufficient for covering the spectrum of microbes commonly seen with chorioamnionitis.…”

A First Look at Chorioamnionitis Management Practice Variation among US Obstetricians

“…A 2002 Cochrane Database Review indicated that there are insufficient data on which to base a recommendation for optimal antibiotic regimens in the setting of chorioamnionitis [13]. Not surprisingly, our results demonstrate a wide variety of antibiotic regimens in common use.…”

“…Not surprisingly, our results demonstrate a wide variety of antibiotic regimens in common use. Most of these regimens contain sufficient Gram-negative coverage and consist of broad spectrum antibiotics that cover for beta-lactamase producing aerobes and anaerobes, as has been recommended by expert consensus and nonrandomized published studies [1–6, 9, 13–16, 22–27]. However, 15% of providers use ampicillin or cefazolin alone, regimens that do not contain Gram-negative coverage and are theoretically insufficient for covering the spectrum of microbes commonly seen with chorioamnionitis.…”

A Survey on Variation in Diagnosis and Treatment of Chorioamnionitis in Tertiary Centres in Canada

“…We saw considerable differences between sites in the choice of antibiotics, the duration of antibiotic treatment, and the criteria determining treatment cessation. The difficulties in establishing antibiotic treatment guidelines for chorioamnionitis from the available literature have been described elsewhere 17 .…”

Clinical chorioamnionitis at term VIII: a rapid MMP-8 test for the identification of intra-amniotic inflammation

“…Currently, the diagnosis of clinical chorioamnionitis is based on maternal clinical signs that have only about a 50% accuracy for the identification of proven intra-amniotic infection (8). The management of mothers with suspected clinical chorioamnionitis includes treatment with antimicrobial agents (47, 71, 104-106) and labor augmentation (4, 6, 73, 107). Neonatologists often perform a laboratory work-up for sepsis and initiate antibiotic treatment (108-114).…”

A First Look at Chorioamnionitis Management Practice Variation among US Obstetricians

“…A 2002 Cochrane Database Review indicated that there are insufficient data on which to base a recommendation for optimal antibiotic regimens in the setting of chorioamnionitis [13]. Not surprisingly, our results demonstrate a wide variety of antibiotic regimens in common use.…”

“…Not surprisingly, our results demonstrate a wide variety of antibiotic regimens in common use. Most of these regimens contain sufficient Gram-negative coverage and consist of broad spectrum antibiotics that cover for beta-lactamase producing aerobes and anaerobes, as has been recommended by expert consensus and nonrandomized published studies [1–6, 9, 13–16, 22–27]. However, 15% of providers use ampicillin or cefazolin alone, regimens that do not contain Gram-negative coverage and are theoretically insufficient for covering the spectrum of microbes commonly seen with chorioamnionitis.…”

A Survey on Variation in Diagnosis and Treatment of Chorioamnionitis in Tertiary Centres in Canada

“…We saw considerable differences between sites in the choice of antibiotics, the duration of antibiotic treatment, and the criteria determining treatment cessation. The difficulties in establishing antibiotic treatment guidelines for chorioamnionitis from the available literature have been described elsewhere 17 .…”

Clinical chorioamnionitis at term VIII: a rapid MMP-8 test for the identification of intra-amniotic inflammation

“…Currently, the diagnosis of clinical chorioamnionitis is based on maternal clinical signs that have only about a 50% accuracy for the identification of proven intra-amniotic infection (8). The management of mothers with suspected clinical chorioamnionitis includes treatment with antimicrobial agents (47, 71, 104-106) and labor augmentation (4, 6, 73, 107). Neonatologists often perform a laboratory work-up for sepsis and initiate antibiotic treatment (108-114).…”

A First Look at Chorioamnionitis Management Practice Variation among US Obstetricians

“…A 2002 Cochrane Database Review indicated that there are insufficient data on which to base a recommendation for optimal antibiotic regimens in the setting of chorioamnionitis [13]. Not surprisingly, our results demonstrate a wide variety of antibiotic regimens in common use.…”

“…Not surprisingly, our results demonstrate a wide variety of antibiotic regimens in common use. Most of these regimens contain sufficient Gram-negative coverage and consist of broad spectrum antibiotics that cover for beta-lactamase producing aerobes and anaerobes, as has been recommended by expert consensus and nonrandomized published studies [1–6, 9, 13–16, 22–27]. However, 15% of providers use ampicillin or cefazolin alone, regimens that do not contain Gram-negative coverage and are theoretically insufficient for covering the spectrum of microbes commonly seen with chorioamnionitis.…”

A Survey on Variation in Diagnosis and Treatment of Chorioamnionitis in Tertiary Centres in Canada

“…We saw considerable differences between sites in the choice of antibiotics, the duration of antibiotic treatment, and the criteria determining treatment cessation. The difficulties in establishing antibiotic treatment guidelines for chorioamnionitis from the available literature have been described elsewhere 17 .…”

Clinical chorioamnionitis at term VIII: a rapid MMP-8 test for the identification of intra-amniotic inflammation

“…Currently, the diagnosis of clinical chorioamnionitis is based on maternal clinical signs that have only about a 50% accuracy for the identification of proven intra-amniotic infection (8). The management of mothers with suspected clinical chorioamnionitis includes treatment with antimicrobial agents (47, 71, 104-106) and labor augmentation (4, 6, 73, 107). Neonatologists often perform a laboratory work-up for sepsis and initiate antibiotic treatment (108-114).…”