Antibiotic prophylaxis for elective hysterectomy

Abstract

Antibiotic prophylaxis appears to be effective in preventing postoperative infection in women undergoing elective vaginal or abdominal hysterectomy, regardless of the dose regimen. However, evidence is insufficient to show whether use of prophylactic antibiotics influences rates of adverse effects. Similarly, evidence is insufficient to show which (if any) individual antibiotic, dose regimen, or route of administration is safest and most effective. The most recent studies included in this review were 14 years old at the time of our search. Thus findings from included studies may not reflect current practice in perioperative and postoperative care and may not show locoregional antimicrobial resistance patterns.

Prophylactic antibiotic bundle compliance and surgical site infections: an artificial neural network analysis

“…Kim, et al [22] in a systematic review and meta-analysis of laparoscopic cholecystectomy found prophylactic antibiotic reduced superficial SSI’s but not deep SSI’s in low-risk patients. On the other hand, several studies have found benefit in colorectal surgery [23–25], neurosurgery [26], hysterectomy [27], as well as a board national surgical database [9]. In fact, in our study, compliance with the antibiotic type and timing was associated with a lower incidence of postoperative SSI, although it did not quite reach statistical significance.…”

Prophylactic antibiotic bundle compliance and surgical site infections: an artificial neural network analysis

“…Kim, et al [22] in a systematic review and meta-analysis of laparoscopic cholecystectomy found prophylactic antibiotic reduced superficial SSI’s but not deep SSI’s in low-risk patients. On the other hand, several studies have found benefit in colorectal surgery [23–25], neurosurgery [26], hysterectomy [27], as well as a board national surgical database [9]. In fact, in our study, compliance with the antibiotic type and timing was associated with a lower incidence of postoperative SSI, although it did not quite reach statistical significance.…”

Surgical site infection in obstetrics and gynaecology: prevention and management

“…The overall effect of prophylactic antibiotics was to decrease the risk of postoperative infection from about 16% to 1–6%. This was also true for vaginal hysterectomy 42 …”

Symptomatic pelvic hematoma following hysterectomy: risk factors, bacterial pathogens and clinical outcome

“…These findings raise the possibility of alternative antibiotic regimens which may give better coverage for possible anaerobic pathogens. As mentioned earlier previous studies have pointed towards the superiority of beta-lactam prophylaxis with regard to risk of infection following hysterectomy [12,13]. These studies did not differentiate between skin infections and vaginal cuff infections.…”

Prophylactic antibiotic bundle compliance and surgical site infections: an artificial neural network analysis

“…Kim, et al [22] in a systematic review and meta-analysis of laparoscopic cholecystectomy found prophylactic antibiotic reduced superficial SSI’s but not deep SSI’s in low-risk patients. On the other hand, several studies have found benefit in colorectal surgery [23–25], neurosurgery [26], hysterectomy [27], as well as a board national surgical database [9]. In fact, in our study, compliance with the antibiotic type and timing was associated with a lower incidence of postoperative SSI, although it did not quite reach statistical significance.…”

Surgical site infection in obstetrics and gynaecology: prevention and management

“…The overall effect of prophylactic antibiotics was to decrease the risk of postoperative infection from about 16% to 1–6%. This was also true for vaginal hysterectomy 42 …”

Symptomatic pelvic hematoma following hysterectomy: risk factors, bacterial pathogens and clinical outcome

“…These findings raise the possibility of alternative antibiotic regimens which may give better coverage for possible anaerobic pathogens. As mentioned earlier previous studies have pointed towards the superiority of beta-lactam prophylaxis with regard to risk of infection following hysterectomy [12,13]. These studies did not differentiate between skin infections and vaginal cuff infections.…”

Prophylactic antibiotic bundle compliance and surgical site infections: an artificial neural network analysis

“…Kim, et al [22] in a systematic review and meta-analysis of laparoscopic cholecystectomy found prophylactic antibiotic reduced superficial SSI’s but not deep SSI’s in low-risk patients. On the other hand, several studies have found benefit in colorectal surgery [23–25], neurosurgery [26], hysterectomy [27], as well as a board national surgical database [9]. In fact, in our study, compliance with the antibiotic type and timing was associated with a lower incidence of postoperative SSI, although it did not quite reach statistical significance.…”

Surgical site infection in obstetrics and gynaecology: prevention and management

“…The overall effect of prophylactic antibiotics was to decrease the risk of postoperative infection from about 16% to 1–6%. This was also true for vaginal hysterectomy 42 …”

Symptomatic pelvic hematoma following hysterectomy: risk factors, bacterial pathogens and clinical outcome

“…These findings raise the possibility of alternative antibiotic regimens which may give better coverage for possible anaerobic pathogens. As mentioned earlier previous studies have pointed towards the superiority of beta-lactam prophylaxis with regard to risk of infection following hysterectomy [12,13]. These studies did not differentiate between skin infections and vaginal cuff infections.…”