Antibiofilm efficacy of green synthesized graphene oxide-silver nanocomposite using Lagerstroemia speciosa floral extract: A comparative study on inhibition of gram-positive and gram-negative biofilms

Kulshrestha, Shatavari; Qayyum, Shariq; Khan, Asad U.

doi:10.1016/j.micpath.2016.12.022

Cited by 73 publications

(41 citation statements)

References 45 publications

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“…As well as, the nanomaterials have a significant impact on the treatment of S. aureus infection by preventing the biofilm formation whereas, the main component of the biofilm is the glycocalyx with anionic charge, it can interact with the nanoparticles with a positive charge which have the ability to penetrate the thick biofilm (Kulshrestha et al, 2017). Sathyanarayanan et al (2013), reported that the gold nanoparticles had a significant decrease in the biofilm that was formed by S. aureus.…”

Section: Inhibition Of Biofilm Formationmentioning

confidence: 99%

Nanoparticles for treatment of bovine Staphylococcus aureus mastitis

2020

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Staphylococcus aureus (S. aureus) is one of the most important zoonotic bacterial pathogens, infecting human beings and a wide range of animals, in particular, dairy cattle. Globally. S. aureus causing bovine mastitis is one of the biggest problems and an economic burden facing the dairy industry with a strong negative impact on animal welfare, productivity, and food safety. Furthermore, its smart pathogenesis, including facultative intracellular parasitism, increasingly serious antimicrobial resistance, and biofilm formation, make it challenging to be treated by conventional therapy. Therefore, the development of nanoparticles, especially liposomes, polymeric nanoparticles, solid lipid nanoparticles, nanogels, and inorganic nanoparticles, are gaining traction and excellent tools for overcoming the therapeutic difficulty accompanied by S. aureus mastitis. Therefore, in this review, the current progress and challenges of nanoparticles in enhancing the S. aureus mastitis therapy are focused stepwise. Firstly, the S. aureus treatment difficulties by the antimicrobial drugs are analyzed. Secondly, the advantages of nanoparticles in the treatment of S. aureus mastitis, including improving the penetration and accumulation of their payload drugs intracellular, decreasing the antimicrobial resistance, and preventing the biofilm formation, are also summarized. Thirdly, the progression of different types from the nanoparticles for controlling the S. aureus mastitis are provided. Finally, the difficulties that need to be solved, and future prospects of nanoparticles for S. aureus mastitis treatment are highlighted. This review will provide the readers with enough information about the challenges of the nanosystem to help them to design and fabricate more efficient nanoformulations against S. aureus infections. ARTICLE HISTORY ). So, these new nanocarriers provide a new strategy to combat S. aureus mastitis problems. In order to provide an overview of the emerging nanocarriers in the bovine mastitis management and help the researcher to understand how they can discover a new trend to combat S. aureus mastitis by shifting their attention toward the world of nanocarriers. We searched PubMed, Scopus, and Web of Science for all the studies published over the last 20 years using the keywords "S. aureus mastitis" or "virulence factors of S. aureus" and "antimicrobial resistance" or "nanoparticles and nanogel". About 3000 records and 550 of closely related papers were screened for suitable studies. We summarized the features and treatment difficulty of S. aureus mastitis, the advantages, and prospects of nanoparticles and nanogels according to the related publications.

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Section: Inhibition Of Biofilm Formationmentioning

confidence: 99%

Nanoparticles for treatment of bovine Staphylococcus aureus mastitis

2020

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“…The utilization of nanoparticles with antibiotics as anti-biofilm or efflux pump inhibitor has been well examined and explored [1, 9–11]. Metallic nanoparticles have been extensively used to treat infections in human cell lines due to their low cytotoxicity (concentration dependent), high surface area, and broad-spectrum antibacterial activity [12–14]. Moreover, the combined application of metallic nanoparticles with an antibiotic reduces their concentration as drug dosage and hence diminishes the toxicity of both agents to human cell lines [15].…”

Section: Reviewmentioning

confidence: 99%

Nanoparticles as Efflux Pump and Biofilm Inhibitor to Rejuvenate Bactericidal Effect of Conventional Antibiotics

Singh²,

2017

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The universal problem of bacterial resistance to antibiotic reflects a serious threat for physicians to control infections. Evolution in bacteria results in the development of various complex resistance mechanisms to neutralize the bactericidal effect of antibiotics, like drug amelioration, target modification, membrane permeability reduction, and drug extrusion through efflux pumps. Efflux pumps acquire a wide range of substrate specificity and also the tremendous efficacy for drug molecule extrusion outside bacterial cells. Hindrance in the functioning of efflux pumps may rejuvenate the bactericidal effect of conventional antibiotics. Efflux pumps also play an important role in the exclusion or inclusion of quorum-sensing biomolecules responsible for biofilm formation in bacterial cells. This transit movement of quorum-sensing biomolecules inside or outside the bacterial cells may get interrupted by impeding the functioning of efflux pumps. Metallic nanoparticles represent a potential candidate to block efflux pumps of bacterial cells. The application of nanoparticles as efflux pump inhibitors will not only help to revive the bactericidal effect of conventional antibiotics but will also assist to reduce biofilm-forming capacity of microbes. This review focuses on a novel and fascinating application of metallic nanoparticles in synergy with conventional antibiotics for efflux pump inhibition.

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“…Silver nanoparticles (AgNPs) are attracting much attention in the fields of biomedical technology because of their antibacterial, anti-biofilm, anti-cancer and antioxidant properties (Taglietti et al 2014;Ghosh et al 2015;Zhang et al 2016). There are reports on anti QS and the biofilm inhibitory activity of green synthesized AgNPs/nanocomposites (Masurkar et al 2012;Singh et al 2015;Kulshrestha et al 2017;Srinivasan et al 2017). Piper betle L. (Pb) is a widely cultivated plant in the Indian subcontinent and Southeast Asia and has long been in use for several medicinal formulations.…”

Section: Introductionmentioning

confidence: 99%

Biofilm inhibition and anti-quorum sensing activity of phytosynthesized silver nanoparticles against the nosocomial pathogen Pseudomonas aeruginosa

et al. 2019

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Quorum sensing (QS), the communication signaling network, regulates biofilm formation and several virulence factors in Pseudomonas aeruginosa PAO1, a nosocomial opportunistic pathogen. QS is considered to be a challenging target for compounds antagonistic to virulent factors. Biologically synthesized silver nanoparticles (AgNPs) are reported as anti-QS and anti-biofilm drugs against bacterial infections. The present study reports on the synthesis and characterization of Piper betle (Pb) mediated AgNPs (Pb-AgNPs). The anti-QS activity of Pb-AgNPs against Chromobacterium violaceum and the potential effect of Pb-AgNPs on QS-regulated phenotypes in PAO1 were studied. FTIR analysis exhibited that Pb-AgNPs had been capped by phytochemical constituents of Pb. Eugenol is one of the active phenolic phytochemicals in Pb leaves, therefore molecular docking of eugenol-conjugated AgNPs on QS regulator proteins (LasR, LasI and MvfR) was performed. Eugenol-conjugated AgNPs showed considerable binding interactions with QS-associated proteins. These results provide novel insights into the development of phytochemically conjugated nanoparticles as promising anti-infective candidates.

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Antibiofilm efficacy of green synthesized graphene oxide-silver nanocomposite using Lagerstroemia speciosa floral extract: A comparative study on inhibition of gram-positive and gram-negative biofilms

Cited by 73 publications

References 45 publications

Nanoparticles for treatment of bovine Staphylococcus aureus mastitis

Nanoparticles for treatment of bovine Staphylococcus aureus mastitis

Nanoparticles as Efflux Pump and Biofilm Inhibitor to Rejuvenate Bactericidal Effect of Conventional Antibiotics

Biofilm inhibition and anti-quorum sensing activity of phytosynthesized silver nanoparticles against the nosocomial pathogen Pseudomonas aeruginosa

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