Antibakterielle Aktivität von Clindamycin und Linkomycin in Bouillon, Serum und in Kombination mit Polymorphkernigen Granulozyten gegen Staphylococcus aureus und Staphylococcus epidermidis

Abstract

We investigated the antibacterial activity of clindamycin and lincomycin at 1/4 X minimum inhibitory concentration (MIC), 1 X MIC and 4 X MIC against a serum-resistant Staphylococcus aureus and a serum-resistant Staphylococcus epidermidis strain in broth, in serum with and without the presence of leukocytes and in Hank's medium in combination with leukocytes alone. Against both test strains, lincomycin in broth and serum was similarly effective, whereas against S. aureus clindamycin in broth was somewhat more active. In the combined test mixture of serum with leukocytes, even a 1/4 X MIC of clindamycin or lincomycin markedly improved leukocyte killing of S. aureus, whereas both compounds could not further enhance the marked leukocyte killing of S. epidermidis, even at inhibitory concentrations. In Hank's medium with leukocytes alone, clindamycin and lincomycin had at the most only a bacteriostatic effect against both test strains.

Reduction of wall degradability of clindamycin-treated staphylococci within macrophages

“…However, there has been a controversial discussion about the intraphagosomal activity of clindamycin. The drug has been reported to be inactive (5,30), bactericidal (2,13,18), and bacteriostatic (1,12).…”