Antibacterial potential of saliva in children with leukemia

Karolewska, Ewa; Konopka, Tomasz; Pupek, Małgorzata; Chybicka, Alicja; Mendak, Magdalena

doi:10.1016/j.tripleo.2007.10.010

Cited by 28 publications

(30 citation statements)

References 27 publications

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“…According to those authors, a statistically significant low salivary S-IgA level was maintained after chemotherapy. 18 A statistically significant lower level of saliva IgA in patients with leukemia (2.9-1.9 μg/mL) as compared to controls (5.4 μg/mL) was reported by Thomaz et al 19 Månsson-Rahemtulla et al also reported that the value of saliva IgA in patients with ALL undergoing chemotherapy was significantly reduced. The authors revealed that at the time of diagnosis, salivary IgA in patients with ALL was 0.183 ±0.193 mg/mL, and that it was higher than in the control group.…”

Section: Discussionmentioning

confidence: 79%

“…According to a pathomechanism outlined by Sonis et al, a low S-IgA concentration in patients undergoing anti-tumor treatment could be partially responsible for a higher risk of mucositis development. 8,18 In my own previous studies, decreases in salivary TNF-α and IL-2 was observed in patients with ALL as compared to healthy children. 25,26 In an effort to minimize the side effects of radiation therapy and chemotherapy used in cancer treatment, there have been studies aimed at developing therapeutic strategies to regenerate oral mucosal tissues affected by mucositis.…”

Section: Discussionmentioning

confidence: 89%

“…Similar correlations have also been observed by other authors. [16][17][18][19][20] Mucositis is most frequently induced by a reduced number of white blood cells, the use of cytotoxic antibiotics and by alkylating factors. 16,17 A significant decrease in salivary S-IgA following chemotherapy in children with leukemia was reported by Karolewska et al, although the authors did not report differences in the S-IgA concentration in comparison with the control group prior to anti-tumor treatment.…”

Section: Discussionmentioning

confidence: 99%

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Oral mucositis and saliva IgA, IgG and IgM concentration during anti-tumor treatment in children suffering from acute lymphoblastic leukemia

Pels¹

2017

Adv Clin Exp Med

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Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

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Oral mucositis and saliva IgA, IgG and IgM concentration during anti-tumor treatment in children suffering from acute lymphoblastic leukemia

Pels¹

2017

Adv Clin Exp Med

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“…The sIgA level then drops back and remains constant after the age of 7, and there is no significant difference in sIgA levels in those between 15 and 70 years of age. Other studies have shown that saliva is stable between the ages of 10 and 12 years [9,10].…”

Section: Discussionmentioning

confidence: 90%

Salivary Secretory Immunoglobulin a Level of Children With Acute Lymphoblastic Leukemia in Maintenance Phase

Rani

Budiardjo

Suharsini

2018

Asian J Pharm Clin Res

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Objective: The objective of this research is to investigate the differences in salivary secretory immunoglobulin A (sIgA) levels between children with gingivitis who have acute lymphoblastic leukemia (ALL) and are in the maintenance phase of chemotherapy and the levels in healthy children with gingivitis.Methods: This study used cross-sectional and laboratory observation methods with 19 ALL children and 19 healthy children who all had mild gingivitis. Two mL of saliva were collected and stored at −200°C. Then, salivary sIgA levels were measured using the ELISA method. Results:The results indicate an insignificant difference (p>0.05) in salivary sIgA levels between the ALL children in the maintenance phase with the level of 21.38 (7.23-107.26) and 37.26 (11.24-135.63) for the healthy children. Conclusion:There is no significant difference in salivary sIgA levels between the ALL children in the maintenance phase and the healthy children.

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“…The decrease in SF may also be the result of alcohol withdrawal syndrome stress. Alcohol www.fhc.viamedica.pl withdrawal syndrome stress is characterized by a significant central and peripheral sympathetic hyperactivity, hypercortisolemia, reduced food intake and fluid diet (which reduces mastication that stimulates SF), and reduced number of muscarinic receptors as well as reduced secretion/action of paracrine gastrointestinal hormones and transmitters such as somatostatin, PP peptide, and cholecystokinin [5,9,[40][41][42].…”

Section: Discussionmentioning

confidence: 99%

Decrease in salivary lactoferrin output in chronically intoxicated alcohol-dependent patients

Waszkiewicz

Zalewska-Szajda

Zalewska

et al. 2012

Folia Histochem Cytobiol.

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Salivary lactoferrin is a glycoprotein involved in the elimination of pathogens and the prevention of massive overgrowth of microorganisms that affect oral and general health. A high concentration of lactoferrin in saliva is often considered to be a marker of damage to the salivary glands, gingivitis, or leakage through inflamed or damaged oral mucosa, infiltrated particularly by neutrophils. We conducted a study to determine the effect of chronic alcohol intoxication on salivary lactoferrin concentration and output. The study included 30 volunteers consisting of ten non-smoking male patients after chronic alcohol intoxication (group A), and 20 control nonsmoking male social drinkers (group C) with no history of alcohol abuse. Resting whole saliva was collected 24 to 48 hours after a chronic alcohol intoxication period. Lactoferrin was assessed by enzyme-linked immunosorbent assay. For all participants, the DMFT index (decayed, missing, or filled teeth), gingival index (GI) and papilla bleeding index (PBI) were assessed. The differences between groups were evaluated using the Mann--Whitney U test. We noticed significantly decreased salivary flow (SF) in alcohol dependent patients after chronic alcohol intoxication (A), compared to the control group (C). Although there was no significant difference in salivary lactoferrin concentration between the alcohol dependent group A and the control group C, we found significantly decreased lactoferrin output in group A compared to group C. We found a significant correlation between the amount of daily alcohol use and a decrease in lactoferrin output. There was a significant increase in GI and a tendency of PBI to increase in group A compared to group C. We demonstrated that chronic alcohol intoxication decreases SF and lactoferrin output. The decreased lactoferrin output in persons chronically intoxicated by alcohol may be the result of lactoferrin exhaustion during drinking (due to its alcohol-related lower 249Alcohol and salivary lactoferrin

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Antibacterial potential of saliva in children with leukemia

Cited by 28 publications

References 27 publications

Oral mucositis and saliva IgA, IgG and IgM concentration during anti-tumor treatment in children suffering from acute lymphoblastic leukemia

Oral mucositis and saliva IgA, IgG and IgM concentration during anti-tumor treatment in children suffering from acute lymphoblastic leukemia

Salivary Secretory Immunoglobulin a Level of Children With Acute Lymphoblastic Leukemia in Maintenance Phase

Decrease in salivary lactoferrin output in chronically intoxicated alcohol-dependent patients

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