Antibacterial Potential of a Newly Synthesized Zinc Peroxide Nanoparticles (Zno2-Nps) to Combat Biofilm-Producing Multi-Drug Resistant  Pseudomonas aeruginosa

El-Shounya, Wagih A.; Moawad, Mahmoud; Haider, Ashraf; Ali, Sameh S.; Nouh, Somaia

doi:10.21608/ejbo.2019.7062.1277

Cited by 6 publications

(4 citation statements)

References 12 publications

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“…It has many applications across a variety of industries: it is used by the rubber industry [1]; it is used in the production of plastics [2], in cosmetics and pharmacy [3]; it is an oxidant for explosives and pyrotechnic mixtures [4], and a precursor to ZnO [5,6,7,8,9,10,11,12,13,14]; it is a photocatalyst [15,16], a luminophore [17,18]; it can be used to purify water [19] and as a detoxification agent against mustard gas [20]. Recently, antibacterial and antiviral properties of ZnO 2 nanoparticles were also reported [21,22]. A progress report by Hu et al published in 2021 summarizes and discusses the advances in the construction of versatile metal peroxide nanoparticles for disease-specific chemoreactive nanotherapeutics [23].…”

Section: Introductionmentioning

confidence: 99%

A comprehensive study of structure and properties of nanocrystalline zinc peroxide

Bocharov

Chesnokov

Chikvaidze

et al. 2022

Journal of Physics and Chemistry of Solids

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Section: Introductionmentioning

confidence: 99%

A comprehensive study of structure and properties of nanocrystalline zinc peroxide

Bocharov

Chesnokov

Chikvaidze

et al. 2022

Journal of Physics and Chemistry of Solids

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“…Biofilm formation occurs in two sequential steps by initial attachment of the bacteria to a solid surface and through the proliferation and accumulation of cells in multilayers and enclosing of the bacterial community in a polymeric matrix this matrix is essentially constituted by exopolysaccharides, but it can also contain surface proteins responsible for the bacteria attachment to surfaces (Oliveira et al, 2006), also contributing to the evasion of the immunological defenses and to the difficulty of pathogen eradication, often resulting in persistent infections (Melchior et al, 2006;El-Shouny et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Antibacterial potential of some seaweeds species to combat biofilm-producing multi-drug resistant Staphylococcus aureus of Nile tilapia

et al. 2019

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T HERE is an increasing worldwide demand for seafood due to the awareness of fish as an important protein source for a growing population. However, the diseases caused by multi-drug resistant (MDR) bacterial infections and the low survival rate of the fish represent significant challenges to fish farmers. The virulence and pathogenicity of bacteria are often enhanced when growing as a biofilm. Therefore, a variety of new antimicrobial drugs has attracted wide attention in treating fish pathogen bacteria. Herein, the efficiency of macroalgal extracts as an antibacterial agent against MDR Staphylococcus aureus bacteria isolated from Nile tilapia (Oreochromis niloticus) was studied. Out of 200 bacterial isolates, 50 strains were identified as S. aureus. Of these strains, 37 were MDR and showed a potential role in the production of virulence factors, including staphylokinase (70.2%), lecithinase (81%), protease (56.7%) and lipase (59.4%). Significant production of biofilm virulence factor by MDR S. aureus strains was also observed from the quantitative and qualitative analysis. Four algal species namely Jania rubens, Ulva lactuca, Sargassum vulgare, and Sargassum fusiforme were tested for their antibacterial activity against MDR S. aureus strains. Of those, S. vulgare diethyl ether extract showed the highest antibacterial. In addition, GC-MS analysis revealed 20 identified components in S. vulgare diethyl ether extract, in which Longifolene was dominant (16.5%). This study thus established the possibility of developing an antibacterial agent to combat developing MDR S. aureus and biofilm-related infections in Nile tilapia.

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“…HPLC results also revealed that the rates of degradation by sophorolipid were 100% for MB and 86.834% for CR, suggesting the high emulsifying activity of biosurfactant (Ghribi et al, 2012) and demonstrating its enhancement of hydrocarbon biodegradation (Mnif et al, 2014). Antibacterial and anti-biofilm activity of biosurfactant Bacterial biofilms are a critical problem, especially for pathogens that exhibit strong drug resistance (El-Shounya et al, 2019;Mohamed et al, 2020a). Here, the antibacterial and antibiofilm effects of biosurfactant produced by Candida tropicalis were investigated on four MDR Klebsiella pneumoniae biofilm-producing pathogenic strains.…”

Section: Degradation Of Different Dyes Determined Using Ftir and Hplcmentioning

confidence: 99%

Applications of Candida tropicalis Bioactive Biosurfactant Produced Using Simple Substrate Medium

et al. 2022

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B IOSURFACTANTS have been generating increasing interest due to their wide range of applications. This work aimed to propose a low-cost method for producing a biosurfactant using Candida tropicalis and studying its optimal conditions and applications.A biosurfactant-producing Candida strain was selected and subjected to molecular identification. Optimum medium composition was determined using Plackett-Burman design; and response surface methodology using the central composite design. The Placket-Burman design showed that the maximum dry weight of biosurfactant (69.06mg/10mL) was obtained at the under optimal conditions of culture medium supplemented with 30g L −1 of carbon source and 1.5g L −1 of nitrogen source and incubation at 42 °C for 15 days. The extracted biosurfactant was characterized using FTIR. The dye decolorization/degradation ability was tested and antibacterial/antibiofilm assays were performed using the tissue culture plate method.Crude biosurfactant of Candida tropicalis showed good antibacterial activity, with inhibition zones ranging from 1 to 2.8cm in diameter against standard bacterial strains. Using FTIR, the biosurfactant was confirmed to be sophorolipid. High degradation rates of 50.76% and 20.88% were recorded for methylene blue and Congo red dyes, respectively, using the partially purified biosurfactant, which was further, confirmed using FTIR analysis and HPLC. The partially purified biosurfactant showed significant anti-biofilm activity against pathogenic MDR Klebsiella pneumoniae biofilm at concentrations of 100 and 50mg mL −1 . Conclusion: Candida tropicalis biosurfactant is potent at degrading different synthetic dyes in water, as well as exerting remarkable antibacterial and anti-biofilm activity against MDR pathogenic bacteria. Our results, suggest the value of using mixed substrates as low-cost substrates to increase the production of biosurfactant by Candida tropicalis.

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Antibacterial Potential of a Newly Synthesized Zinc Peroxide Nanoparticles (Zno2-Nps) to Combat Biofilm-Producing Multi-Drug Resistant Pseudomonas aeruginosa

Cited by 6 publications

References 12 publications

A comprehensive study of structure and properties of nanocrystalline zinc peroxide

A comprehensive study of structure and properties of nanocrystalline zinc peroxide

Antibacterial potential of some seaweeds species to combat biofilm-producing multi-drug resistant Staphylococcus aureus of Nile tilapia

Applications of Candida tropicalis Bioactive Biosurfactant Produced Using Simple Substrate Medium

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