Antibacterial and antitumor activities of a lectin-rich preparation from Microgramma vacciniifolia rhizome

Silva, Gabriela Cavalcante da; Oliveira, Alisson Macário de; Costa, Wêndeo Kennedy; Filho, Antônio Felix da Silva; Pitta, Maíra Galdino da Rocha; Rêgo, Moacyr Jesus Barreto de Melo; Souza, Ivone Antônia de; Paiva, Patrícia Maria Guedes

doi:10.1016/j.crphar.2022.100093

Cited by 5 publications

(3 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Contagious bacterial illness resulted fatalities all over the world including less economically developed nations (Nair et al, 2013). Infections remain closely linked to illness and death (Cavalcante et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

“…The 2020 World Health Organization report recorded 48.9 million infections in 2017, leading to 11 million sepsis-related deaths worldwide (Cavalcante et al, 2022). These infections, caused by both Grampositive and Gram-negative bacteria, are responsible for severe human illnesses (Nair et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

“…Plant materials, rich in glycoproteins with inherent toxicity, significantly impact various biological processes (Khatun et al, 2009). Exploring plantderived phytochemical compounds holds promise for innovative antimicrobial agents (Cavalcante et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Antibacterial Properties and Cytotoxicity of Geodorum Densiflorum Rhizome Lectin: A Promising Solution to Combat Antibiotic Resistance

2023

Int. J. Biosci.

View full text Add to dashboard Cite

Antibiotic resistance is a pressing issue in modern medicine, posing a significant concern in the 21 st century.Microorganisms have developed new resistance mechanisms that spread widely, endangering our ability to treat various infectious diseases and increasing nosocomial infections. Lectins, which exhibit broad antibacterial activity, work based on carbohydrate specificity, varying in effectiveness depending on the plant species from which they are derived from. They offer a potential alternative to combat antibiotic resistance. However, further research is needed for clinical application. In our study, we explored the physiological effects of GDL, a lectin weighing around 12 ± 1 kDa, sourced from Geodorum densiflorum (Lam.) rhizomes. We assessed its antibacterial activity against six bacterial strains (Staphylococcus aureus, Shigella boydii, E. coli, Shigella sonnei, Agrobacterium sp., and Shigella dysentery). GDL displayed varying levels of growth inhibition, with minimal inhibitory concentrations ranging from 40 to 320 μg/mL. Additionally, we examined the cytotoxicity of Geodorum densiflorum lectin using the brine shrimp lethality bioassay. GDL exhibited dose-dependent toxicity towards Artemia larvae, with an LC50 value of 385 µg/ml. This cytotoxic result suggests that future research on lectin applications from Geodorum densiflorum rhizomes may have significant implications in clinical microbiology, paving the way for further in-depth investigations.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%