“…Apoptosis is an important pathway of LAAOs of exerting cytotoxicity activity selectively against cancer cells, it is reported many previous reports [37,[43][44][45][46][47]. Several of the LAAOs isolated have been considered cytotoxic, including APIT to Jurkat T cells [48], Vipera berus berus LAAO to HeLa and K562 cells [49], BpirLAAOI to S180 cells and macrophages [50], ABU-LAO to human monocytes and T cells [43], BmooLAAO-I to Ehrlich ascites tumor cells [23], BatroxLAAO to HL-60, Jurkat, B16F10, and PC12 cells [49], ACTX-8 to HeLa cells [37], BjarLAAO-I to Ehrlich ascites tumour [45], BF-LAAO to A549 cells [35], BpLAAO to SKBR3 breast carcinoma and Jurkat leukemia cells [49], BmarLAAO to macrophages [51], Bl-LAAO to LL-24, RKO, HUTU, and MKN-45 cells [52], and LmLAAO to AGS cellsgastric adenocarcinoma and MCF-7 cells-breast adenocarcinoma [53]. Cura et al [54] reported that Ophiophagus hannah LAAO venom decreases thymidine uptake in fibrosarcoma, colorectal cancer and Chinese hamster ovary cell line as well as also showed reduction in cellular proliferation.…”