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Cited by 98 publications
(57 citation statements)
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“…Bothrops marajoensis venom LAAO (BmarLAAO) was shown to inhibit the growth of Pseudomonas aeruginosa, Candida albicans, and S. aureus with a MIC of 50.0 μg/mL. Moreover, BmarLAAO also inhibited the parasitic growth of promastigote forms of Leishmania chagasi significantly with an IC 50 =2.86 μg/mL and L. amazonensis with an IC 50 = 2.55 μg/mL (Costa Torres et al 2010). BmLAO from the Bothropoides mattogrosensis pit viper venom and peptide fragments of BmLAO also showed remarkable antibacterial activity against Gram-positive (Bacillus subtilis, Enterococcus faecalis, S. aureus, and Streptococcus pyogenes) and Gram-negative (E. coli, Klebsiella pneumoniae, Proteus mirabilis, P. aeruginosa, and Salmonella typhimurium) bacteria, whereas no cytotoxic activities against macrophages and erythrocytes were observed (Okubo et al 2012).…”
Section: Selective Antibacterial Actions Of Laaosmentioning
confidence: 99%
“…Bothrops marajoensis venom LAAO (BmarLAAO) was shown to inhibit the growth of Pseudomonas aeruginosa, Candida albicans, and S. aureus with a MIC of 50.0 μg/mL. Moreover, BmarLAAO also inhibited the parasitic growth of promastigote forms of Leishmania chagasi significantly with an IC 50 =2.86 μg/mL and L. amazonensis with an IC 50 = 2.55 μg/mL (Costa Torres et al 2010). BmLAO from the Bothropoides mattogrosensis pit viper venom and peptide fragments of BmLAO also showed remarkable antibacterial activity against Gram-positive (Bacillus subtilis, Enterococcus faecalis, S. aureus, and Streptococcus pyogenes) and Gram-negative (E. coli, Klebsiella pneumoniae, Proteus mirabilis, P. aeruginosa, and Salmonella typhimurium) bacteria, whereas no cytotoxic activities against macrophages and erythrocytes were observed (Okubo et al 2012).…”
Section: Selective Antibacterial Actions Of Laaosmentioning
confidence: 99%
“…Secreted PLA 2 s (sPLA 2 ) share several characteristics: low molecular mass (13–18 kDa), numerous disulfide bonds, histidyl and aspartyl catalytic residues and a highly conserved calcium (Ca 2+ ) binding region [13,14]. PLA 2 s from snake venom exhibit a variety of pharmacological/toxicological activities, such as myotoxicity, neurotoxicity, anticoagulant activity, edema-forming activity, cardiotoxicity, antibacterial activity, antiparasite effect and anti-aggregation activity on platelets, among others [15,16,17,18,19,20,21,22,23,24,25]. …”
Section: Introductionmentioning
confidence: 99%
“…Based on the already described antimicrobial and anti-parasitic activity of PLA 2 [17,25,26,27,28] from snake venoms, the antimalarial potential of the venom of B. asper and PLA 2 s from this venom were explored. Two PLA 2 s from the whole venom were purified and characterized, and their in vitro antiplasmodial activity against P. falciparum was investigated.…”
Section: Introductionmentioning
confidence: 99%
“…Apoptosis is an important pathway of LAAOs of exerting cytotoxicity activity selectively against cancer cells, it is reported many previous reports [37,[43][44][45][46][47]. Several of the LAAOs isolated have been considered cytotoxic, including APIT to Jurkat T cells [48], Vipera berus berus LAAO to HeLa and K562 cells [49], BpirLAAOI to S180 cells and macrophages [50], ABU-LAO to human monocytes and T cells [43], BmooLAAO-I to Ehrlich ascites tumor cells [23], BatroxLAAO to HL-60, Jurkat, B16F10, and PC12 cells [49], ACTX-8 to HeLa cells [37], BjarLAAO-I to Ehrlich ascites tumour [45], BF-LAAO to A549 cells [35], BpLAAO to SKBR3 breast carcinoma and Jurkat leukemia cells [49], BmarLAAO to macrophages [51], Bl-LAAO to LL-24, RKO, HUTU, and MKN-45 cells [52], and LmLAAO to AGS cellsgastric adenocarcinoma and MCF-7 cells-breast adenocarcinoma [53]. Cura et al [54] reported that Ophiophagus hannah LAAO venom decreases thymidine uptake in fibrosarcoma, colorectal cancer and Chinese hamster ovary cell line as well as also showed reduction in cellular proliferation.…”
Section: Recent Update On Cancer Managementmentioning
confidence: 99%