Antibacterial and antifungal activity of photoactivated ZnO nanoparticles in suspension

Kairyte, Kristina; Kadys, A.; Lukšienė, Živilė

doi:10.1016/j.jphotobiol.2013.07.017

Cited by 210 publications

(98 citation statements)

References 27 publications

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“…Similar results on antibacterial effect for P. aeruginosa and E. coli by ZnO NPs were reported previously in the literature [24]. The mechanism of antibacterial activity of ZnO NPs may be attributed to the penetration and disintegration of the membrane by smaller sized NPs which lead to cell lysis [25,26]. The release of H 2 O 2 from the surface of ZnO also reported as the possible mechanism for bactericidal activity.…”

Section: Antibacterial Activitysupporting

confidence: 84%

Fabrication of hollow particles composed of silica containing gadolinium compound and magnetic resonance imaging using them

et al. 2013

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A facile, eco-friendly synthesis of zinc oxide nanoparticles (ZnO NPs) employing Bauhinia tomentosa leaf extract as bioreducing agent was reported. The green-synthesized ZnO NPs were characterized by UV-Vis, TEM, EDX, XRD, and FTIR analyses. The formation of ZnO NPs was confirmed by the appearance of characteristic SPR peak at 370 nm due to the collective oscillation of electrons in the conduction band in UV-Vis spectra. The hexagonal morphology exhibiting nanosized ZnO was observed from the TEM and XRD analyses. The chemical bonds present in the as-synthesized ZnO NPs were identified by FTIR analysis. ZnO NPs showed a significant antibacterial activity against Gram-negative bacteria P. aeruginosa and E. coli than Gram-positive bacteria. Results of this study demonstrated that B. tomentosa leaf extract containing phytochemicals such as alkaloids, terpenoids, flavonoids, tannins, carbohydrates, and sterols possess bioreducing property for ZnO synthesis and the obtained ZnO NPs could be employed effectively as a better bactericidal agent for biological applications. Graphical abstract

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Section: Antibacterial Activitysupporting

confidence: 84%

Fabrication of hollow particles composed of silica containing gadolinium compound and magnetic resonance imaging using them

et al. 2013

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“…The ZnO ENPs were irradiated at the Massachusetts Institute of Technology Nuclear Reactor Laboratory (Cambridge, MA, USA) with thermal neutron flux of 5×10 13 n/(cm⋅s) for 120 hours. Neutron irradiation generated 65 Zn, which decays with a half-life of 244.3 days and emits gamma energies of 345, 770, and 1,115 keV.…”

Section: Pharmacokinetic Studiesmentioning

confidence: 99%

“…12 The associated cytotoxicity from these mechanisms is thought to be selective for cells that produce greater levels of ROS or are dividing rapidly, such as immune cells, 5 bacteria, 13 and cancer cells. 6 A prime example of immune cells potentially susceptible to ENP-mediated alterations is Kupffer cells.…”

Section: Introductionmentioning

confidence: 99%

Effects of zinc oxide nanoparticles on Kupffer cell phagosomal motility, bacterial clearance, and liver function

Watson¹,

Molina²,

Louzada³

et al. 2015

IJN

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Background Zinc oxide engineered nanoparticles (ZnO ENPs) have potential as nanomedicines due to their inherent properties. Studies have described their pulmonary impact, but less is known about the consequences of ZnO ENP interactions with the liver. This study was designed to describe the effects of ZnO ENPs on the liver and Kupffer cells after intravenous (IV) administration. Materials and methods First, pharmacokinetic studies were conducted to determine the tissue distribution of neutron-activated 65 ZnO ENPs post-IV injection in Wistar Han rats. Then, a noninvasive in vivo method to assess Kupffer cell phagosomal motility was employed using ferromagnetic iron particles and magnetometry. We also examined whether prior IV injection of ZnO ENPs altered Kupffer cell bactericidal activity on circulating Pseudomonas aeruginosa . Serum and liver tissues were collected to assess liver-injury biomarkers and histological changes, respectively. Results We found that the liver was the major site of initial uptake of 65 ZnO ENPs. There was a time-dependent decrease in tissue levels of 65 Zn in all organs examined, refecting particle dissolution. In vivo magnetometry showed a time-dependent and transient reduction in Kupffer cell phagosomal motility. Animals challenged with P . aeruginosa 24 hours post-ZnO ENP injection showed an initial (30 minutes) delay in vascular bacterial clearance. However, by 4 hours, IV-injected bacteria were cleared from the blood, liver, spleen, lungs, and kidneys. Seven days post-ZnO ENP injection, creatine phosphokinase and aspartate aminotransferase levels in serum were significantly increased. Histological evidence of hepatocyte damage and marginated neutrophils were observed in the liver. Conclusion Administration of ZnO ENPs transiently inhibited Kupffer cell phagosomal motility and later induced hepatocyte injury, but did not alter bacterial clearance from the blood or killing in the liver, spleen, lungs, or kidneys. Our data show that diminished Kupffer cell organelle motion correlated with ZnO ENP-induced liver injury.

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“…Las NP-ZnO poseen actividad antifúngica según Sharma et al (Sharma et al, 2010), Kairyte et al (Kairyte, Kadys & Luksiene, 2013) y Gondal et al (Gondal et al, 2012). Esta propiedad se relaciona con la capacidad fotocatalítica presente en las NPZnO y la producción de ROS, las cuales interactúan con la membrana celular de los hongos.…”

Section: Actividad Antifúngicaunclassified

Textiles Funcionales Como Barrera De Protección Ante Infecciones Asociadas a La Atención en Salud

Giraldo

Palacio

Suaza

et al. 2018

reveia

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RESUMENLos tejidos reforzados con nanoestructuras se ha convertido en un área de la investigación que busca contener la transmisión de microorganismos relacionados con las infecciones asociadas a la atención en salud, un problema de salud pública conlleva una alta carga de morbi-mortalidad en la población y pérdidas millonarias de recursos económicos. Las nanopartículas metálicas y óxido metálicas son agentes antimicrobianos que han cobrado importancia por su amplia

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Antibacterial and antifungal activity of photoactivated ZnO nanoparticles in suspension

Cited by 210 publications

References 27 publications

Fabrication of hollow particles composed of silica containing gadolinium compound and magnetic resonance imaging using them

Fabrication of hollow particles composed of silica containing gadolinium compound and magnetic resonance imaging using them

Effects of zinc oxide nanoparticles on Kupffer cell phagosomal motility, bacterial clearance, and liver function

Textiles Funcionales Como Barrera De Protección Ante Infecciones Asociadas a La Atención en Salud

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