Antibacterial and Anticancer Properties of<i>Dolichos kilimandscharicus</i>(Fabaceae)

Shava, Charity; Mutsaka, Princess; Moyo, Batanai; Sithole, Simbarashe; Chitemerere, Tariro; Mukanganyama, Stanley

doi:10.1080/22311866.2016.1184990

Cited by 3 publications

(3 citation statements)

References 26 publications

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“…The chromone derivative, acthaside isolated from dried bark of Acacia ataxacantha exhibited antibacterial activity against both Gram-positive and Gram-negative microorganisms, though Gram-positive bacteria showed a greater susceptibility overall [52]. In Dolichos kilimandscharicus , saponins were found to inhibit Gram-positive bacteria [53]. Gram-positive bacteria also succumbed to the CW-destabilizing effects of terpenoids and flavonoids in extracts of Cassia abbreviata, Senna didymobotrya , Parkinsonia aculeata [54].…”

Section: Discussionmentioning

confidence: 99%

Leveraging Phytochemicals: The Plant Phylogeny Predicts Sources of Novel Antibacterial Compounds

2019

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Aim: The goal of this study was to use phylogenetic evidence to determine plant families with high representation of antibacterial activity and identify potential sources to focus on for antibacterial drug discovery. Materials & methods: We reconstructed the molecular phylogeny of plant taxa with antibacterial activity and mapped antibacterial mechanisms of action on the phylogeny. Results: The phylogeny highlighted seven plant families (Combretaceae, Cupressaceae, Fabaceae, Lamiaceae, Lauraceae, Myrtaceae and Zingiberaceae) with disproportionately represented antibacterial activity. Phytochemicals produced were primarily involved in the disruption of the bacterial cell wall/membrane and inhibition of quorum sensing/biofilm production. Conclusion: The study provides phylogenetic evidence of seven plant families that should be examined as promising leads for novel antibacterial development.

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Section: Discussionmentioning

confidence: 99%

Leveraging Phytochemicals: The Plant Phylogeny Predicts Sources of Novel Antibacterial Compounds

2019

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“…Root and tuber of D. kilimandscharicus are known for antifungal and ant-molluscicidal properties attributed by saponins [53,54]. In this study, D. kilimandscharicus tuber extracts revealed the highest toxicity with LC 50 values of 7.937 × 10 −4 mg/mL, 3.5192 × 10 −3 mg/mL, 1.468 × 10 −2 mg/ mL, and 7.242 × 10 −2 mg/mL for pet ether, water, ethyl acetate, and methanolic extracts, respectively (Table 2).…”

Section: Determination Of Antibacterial Activitymentioning

confidence: 99%

Antimicrobial and Cytotoxicity Activities of Medicinal Plants against Salmonella gallinarum Isolated from Chickens

Mkangara

Mpenda

2022

Veterinary Medicine International

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Medicinal plants have been the good source of treatment for different ailments of humans as well as animals for centuries. However, in Tanzania, few plants were investigated for their efficacy against various diseases of chickens. In the present study, four medicinal plants were investigated against Salmonella gallinarum isolated from chickens. The minimum inhibitory concentration (MIC) using the broth microdilution methods and minimum bactericidal concentration (MBCs) were used to evaluate the activities of plants against chicken salmonellosis. For the safety of chickens against the toxicity of plants, the cytotoxicity assay was determined using a brine shrimp lethality test. Aloe secundiflora leaf ethyl acetate (ALEA), Aloe rabaiensis leaf methanolic (ArM), Aloe rabaiensis leaf ethyl acetate (ArLEA), and Punica granatum leaf ethyl acetate (PGLEA) extracts exhibited the highest MIC (0.3906 mg/mL) and MBC (3.125 mg/mL), respectively. The Dolichos kilimandscharicus tuber ethyl acetate (DTEA) and Dolichos kilimandscharicus tuber pet ether (DTPE) extracts displayed MIC of 1.563 mg/mL and 12.50 mg/mL and MBC of 12.50 mg/mL and 25.50 mg/mL, respectively. The highest LC50 values exhibited in Dolichos kilimandscharicus ranged from 7.937 × 10−4 mg/mL to 7.242 × 10−2 mg/mL for pet ether and methanolic extracts, respectively, while ALEA extract exhibited LC50 of 7.645 × 10−3 mg/mL. Generally, the extracts with MIC 0.3906 mg/mL and MBC 3.125 mg/mL demonstrated the highest antibacterial activity with low toxicity efficient to manage chicken salmonellosis. Dolichos kilimandscharicus, which exhibited higher toxicity, warrants further investigation on insecticidal and anticancer agents.

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“…The chromone derivative, acthaside isolated from dried bark of Acacia ataxacantha displayed antibacterial activity against both Gram-positive and Gram-negative microorganisms, though Grampositive bacteria showed a greater susceptibility overall(Amoussa, Bourjot, Lagnika, Vonthron-Sénécheau, & Sanni, 2016). In Dolichos kilimandscharicus, saponins were found to hinder Gram-positive bacteria(Shava et al, 2016).Gram-positive bacteria likewise surrendered to the cell wall destabilizing effects of terpenoids and flavonoids in extracts of Cassia abbreviata, Senna didymobotrya and Parkinsonia aculeata(Madureira, Ramalhete, Mulhovo, Duarte, & Ferreira, 2012) polyphenolic extracts from Vicia faba, Cajanus indica(Chanda, Dudhatra, & Kaneria, 2010) Arachis hypogea(Tamura, Ozawa, Tanaka, Arai, & Mura, 2016) and other legume species rich in isoflavonoids (Araya-Cloutier, Den Besten, Aisyah, Gruppen, & Vincken, 2017) had intense antibacterial activity against Gram-positive bacteria. Despite the fact, that Fabaceae species possess phytochemical diversity that may be synergistically damaging the cell wall, flavonoids could be one of the primary phytochemicals responsible as they form complexes with soluble proteins on bacterial cell walls(Yahaya & Idris, 2017).…”

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2020

The International Journal of Biotechnology

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Contrary to the synthetic drugs, phytochemical constituents of plant origin possess an enormous therapeutic potential as antibacterial and antidiabetic agents. The phytochemicals of Senna auriculata floral extracts and avaram tea were screened and tested for antibacterial and antidiabetic properties respectively. Antibacterial activity was determined by disc diffusion method at 0.25, 0.50 and 1.00% concentrations against Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa and Staphylococcus aureus. Overall results indicated maximum antibacterial activity at the lowest concentration (0.25%) by the petroleum ether, acetone, ethyl acetate and methanol extracts against Escherichia coli, Staphylococcus aureus; Escherichia coli and Staphylococcus aureus and their respective zone of inhibition values were 32, 28, 22 and 15mm; at the highest concentration (1.00%) it was exhibited against Staphylococcus aureus for all extracts except for methanol against Klebsiella pneumonia and the values were 36, 34, 30 and 19mm respectively. Experiments were carried with male albino wistar mice treated with streptozotocin to study the antidiabetic property for a period of 21 days. The body weight of mice after treatment decreased on Day 7 when compared to Day 3 and then increased on Day 14 and 21. The blood glucose level decreased right from Day 3 to 21. Further, it is suggested that the molecular basis for the modes of action of plant-based antibiotics and antidiabetics be ascertained and determined. Contribution/Originality: This study documents and highlights Avaram tea as a potential antidiabetic agent as the flowers of Senna auriculata is prescribed for diabetes in traditional practices in Siddha, besides its phytochemical compounds with proven antibacterial action. 1. INTRODUCTION On one hand, infectious diseases are the leading cause of death throughout the world, and drug resistance to human pathogenic bacteria has been commonly reported from all over the world (Cohen, 1992; Piddock & Wise, 1989). Antibiotic resistance has become a global concern. Increasing development of drug resistance in human pathogens as well as the appearance of side effect of synthetic drugs need to develop new antimicrobial drugs from

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Antibacterial and Anticancer Properties ofDolichos kilimandscharicus(Fabaceae)

Cited by 3 publications

References 26 publications

Leveraging Phytochemicals: The Plant Phylogeny Predicts Sources of Novel Antibacterial Compounds

Leveraging Phytochemicals: The Plant Phylogeny Predicts Sources of Novel Antibacterial Compounds

Antimicrobial and Cytotoxicity Activities of Medicinal Plants against Salmonella gallinarum Isolated from Chickens

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