Antibacterial activity, optical, mechanical, thermal, and dielectric properties of L-phenylalanine fumaric acid single crystals for biomedical, optoelectronic, and photonic applications

Darling, D. Abila; Joema, S. E.

doi:10.1007/s10854-020-04744-2

Cited by 18 publications

(5 citation statements)

References 44 publications

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“…An absorption band observed at 257 nm may be due to the presence of aromatic side chains of the tosylate anion in the title compound. [ 19 ] The sample has no absorbance in the particular region (300–1200 nm), which is a key advantage for the grown crystal that may be used in NLO applications. [ 20,21 ] The absorption coefficient is considered a significant parameter when the material is used in optical applications.…”

Section: Resultsmentioning

confidence: 99%

Growth, Optical, Thermal, Antibacterial Activity and Computational Study of Highly Efficient Organic NLO Crystal: 2‐Amino‐1‐methyl‐4‐oxo‐4, 5‐dihydro‐1H‐imidazol‐3‐ium 4‐methyl‐benzene‐sulfonate

Shyla,

Jebamalar,

Vinitha

2023

Cryst. Res. Technol.

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A good organic single crystal of 2‐Amino‐1‐methyl‐4‐oxo‐4, 5‐di‐hydro‐1H‐imidazol‐3‐ium 4‐methyl‐benzene‐sulfonate (2ADPTS) is grown by slow evaporation technique, and the orthorhombic system with noncentrosymmetric space group (P212121) is corroborated by single‐crystal X‐ray diffraction analysis. The structural parameters of the 2ADPTS crystal are investigated and weighted up with the theoretical interpretation. The Hydrogen–Hydrogen interaction with (43.6%) in 2ADPTS promotes crystal structure packing stabilization. The presence of various functional groups and chemical composition of the 2ADPTS compound is identified by FTIR and FT‐Raman spectroscopy. The natural bond orbital evaluation interprets all the possible hydrogen bonding interactions and charge delocalizations in the crystal structure. Thermal analysis confirmed the thermal stability of the 2ADPTS crystal. The absorption spectrum of the 2ADPTS crystal is recorded using UV–Vis spectroscopy. The third‐order nonlinear property of the 2ADPTS crystal is confirmed by using the Z‐scan technique. The higher significant antibacterial activity of 2ADPTS is carried out by the standard Kirby‐Bauer test against four pathogenic bacteria commonly called the agar well diffusion process.

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Section: Resultsmentioning

confidence: 99%

Growth, Optical, Thermal, Antibacterial Activity and Computational Study of Highly Efficient Organic NLO Crystal: 2‐Amino‐1‐methyl‐4‐oxo‐4, 5‐dihydro‐1H‐imidazol‐3‐ium 4‐methyl‐benzene‐sulfonate

Shyla,

Jebamalar,

Vinitha

2023

Cryst. Res. Technol.

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“…As the aqueous extract of the stem showed better activity, this could be due to the presence of a derivative of mandalic acid. Mandelic acid is used in the treatment of skin problems and is an antibacterial agent, particularly against urinary tract infections [ 79 , 80 , 81 ]. Recently, derivatives of mandelic acids have also shown potent in vitro cytotoxicity activity against the HEK-293, MCF-7, PC-3, and HepG-2 cell lines [ 45 ].…”

Section: Cytotoxicity Potential Of Nepeta Paulsenii ...mentioning

confidence: 99%

Cytotoxicity against A549 Human Lung Cancer Cell Line via the Mitochondrial Membrane Potential and Nuclear Condensation Effects of Nepeta paulsenii Briq., a Perennial Herb

Hanif

Ibrahim

Ismail³

et al. 2023

Molecules

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The genus Nepeta belongs to the largest Lamiaceae family, with 300 species, which are distributed throughout the various regions of Africa, Asia, India, and America. Along with other plant families distinguished by their medicinal and therapeutic values, the Nepeta genus of Lameaceae remains relatively valuable. Hence, the phytochemicals of N. paulsenii Briq. were extracted using different plant parts, i.e., leaves, stem, roots, flowers, and the whole plant by using various solvents (ethanol, water, and ethyl acetate), obtaining 15 fractions. Each extract of dried plant material was analyzed by FT-IR and GC-MS to identify the chemical constituents. The cytotoxicity of each fraction was analyzed by MTT assay and mitochondrial membrane potential and nuclear condensation assays against lung cancer cells. Among the ethyl acetate and ethanolic extracts, the flowers showed the best results, with IC50 values of 51.57 μg/mL and 50.58 μg/mL, respectively. In contrast, among the water extracts of the various plant segments, the stem showed the best results, with an IC50 value of 123.80 μg/mL. 5-flourouracil was used as the standard drug, providing an IC50 value of 83.62 μg/mL. The Hoechst 33342 stain results indicated apoptotic features, i.e., chromatin dissolution and broken down, fragmented, and crescent-shaped nuclei. The ethanolic extracts of the flowers showed more pronounced apoptotic effects on the cells. The mitochondrial membrane potential indicated that rhodamine 123 fluorescence signals suppressed mitochondrial potential due to the treatment with the extracts. Again, the apoptotic index of the ethanolic extract of the flowers remained the highest. Hence it can be concluded that the flower part of N. paulsenii Briq. was found to be the most active against the A459 human lung cancer cell line.

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“…Other important parameters like electrical susceptibility (χ c ), imaginary (ϵ i ) and real part (ϵ r ) of dielectric constants were also calculated at 530 nm (absorption edge). By combining the computed values of extinction coefficient (k), refractive index (n) and constant ϵ o , χ c is calculated for the novel DSNA crystal using Equation 5 [40]

\vcenter{\openup.5em\halign{$\displaystyle{#}$\cr {\chi }_{c}={{\ {\mu }^{2}-{k}^{2}-{\varepsilon{} }_{o}}\over{4\pi }}\hfill\cr}}

…”

Section: Morphology Within the Dsna Crystalmentioning

confidence: 99%

“…By combining the computed values of extinction coefficient (k), refractive index (n) and constant ɛ o , χ c is calculated for the novel DSNA crystal using Equation ( 5). [40]…”

Section: Optical and Electrical Conductivitymentioning

confidence: 99%

Physicochemical and Nonlinear Optical Properties of a Stilbazolium Family Single Crystal with Third Order Nonlinear Optical Activity

Anand

Rani

2023

ChemPhotoChem

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The idea of incorporating a novel counter anion group with the organic stilbazolium cation (C16H19N2+) yields a new third harmonic generation active single crystal of 4‐[2‐(4‐Dimethylamino‐phenyl)‐vinyl]‐1‐methyl‐pyridinium 2‐Nitroaniline‐4‐sulfonate (DSNA). The slow evaporation solution growth technique is employed to obtain DSNA crystals, whose nonlinear responses are analyzed through a continuous wave laser Z scan experiment. The thermally induced strong reverse saturation absorption and self‐defocusing behaviour of DSNA crystal infers the aptness of the material as an optical limiting device. Optical characterization outcomes imply that the lower absorption edge falls in the visible region (530 nm), with a broad transparency range of 0.53 to 1 μm. Exploration of other optical constants, extinction coefficient (k = 10‐4), emission wavelength (620 nm – red light), optical (σopt = 1010 Ωm‐1) and electrical conductivity (σelc = 1011 Ωm‐1) also concludes that DSNA crystal is a possible applicant for optoelectronic devices. The various bonds and corresponding lengths and angles involved in the formation of DSNA ionic crystal are evaluated by means of the Single Crystal X‐Ray Diffraction (SCXRD) technique. Linear and nonlinear optical property findings undoubtedly affirm that the titular DSNA crystal is an effectual Nonlinear Optical (NLO) crystal.

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Antibacterial activity, optical, mechanical, thermal, and dielectric properties of L-phenylalanine fumaric acid single crystals for biomedical, optoelectronic, and photonic applications

Cited by 18 publications

References 44 publications

Growth, Optical, Thermal, Antibacterial Activity and Computational Study of Highly Efficient Organic NLO Crystal: 2‐Amino‐1‐methyl‐4‐oxo‐4, 5‐dihydro‐1H‐imidazol‐3‐ium 4‐methyl‐benzene‐sulfonate

Growth, Optical, Thermal, Antibacterial Activity and Computational Study of Highly Efficient Organic NLO Crystal: 2‐Amino‐1‐methyl‐4‐oxo‐4, 5‐dihydro‐1H‐imidazol‐3‐ium 4‐methyl‐benzene‐sulfonate

Cytotoxicity against A549 Human Lung Cancer Cell Line via the Mitochondrial Membrane Potential and Nuclear Condensation Effects of Nepeta paulsenii Briq., a Perennial Herb

Physicochemical and Nonlinear Optical Properties of a Stilbazolium Family Single Crystal with Third Order Nonlinear Optical Activity

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