Antibacterial activity of dental gels containing combinations of amine fluoride, stannous fluoride, and chlorhexidine against cariogenic bacteria

Abstract

– The in vitro susceptibility of Streptococcus mutans, S. sobrinus and Lactobacillus casei to dental gels containing various combinations of amine fluoride (AmF 297), stannous fluoride (SnF2), and chlorhexidine (CHX) was studied. The combination of AmF‐SnF2 with a total fluoride content of 1.2% was the most effective against mutans streptococci but not against L. casei. At notably lower total fluoride concentration (0.4%), AmF as such or combined with SnF2, was significantly less effective against mutans streptococci than CHX or CHX‐AmF‐SnF2 combinations. CHX‐AmF combination was a slightly more potent inhibitor of streptococcal growth than CHX‐NaF. With L. casei the differences between various gels were small but CHX alone seemed to be the most effective. Of the studied agents, CHX seemed to be the most potent individual chemotherapeutic compound whose activity against S. mutans could be enhanced by combining it with AmF. However, clinical experiments are required to test the in vivo antibacterial efficacy of CHX‐AmF and AmF‐SnF2 combinations which were most effective in our in vitro experiments.

Comparative antibacterial effects of chlorhexidine and stannous fluoride‐amine fluoride containing dental gels against salivary mutans streptococci

“…Although in vitro tests have shown SnFo-AmF gel to be even slightly niore potent inhibitor o^Streptococcus mutans and S. sobrinus than chlorhexidine (17), the in vivo situation was not the same. SnF.,-AmF gel was significantly antistreptococcal but less effective than chlorhexidine.…”

“…Because stannous fluoride (SnF9; 5,13,14) and amine fluoride (AmF; 15) also exhibit .significant antibacterial properties against oral mutans streptococci and lactobacilh, their combination has been studied as a possibility to combat oral cariogenic bacteria (16,17). Although in vitro studies have shown SnFj-AmF combinations to be as effective as GHX against mutans streptococci (16,17), SnF,-AmF solution with a low total F~ content (0.025%) did not prevent plaque accumulation, nor the growth of oral mutans streptococci (18). This was clearly in contrast to a GHX solution (0.12%).…”

“…In the present study we have analyzed how a higher concentration of SnFj-AmF (1.20% F~), incorporated into a dental gel, affects the in vivo levels of salivary mutans streptococci and lactobacilli. This concentration of SnF,-AmF was chosen because in our previous in vitro study (17) it was as effective as 1% GHX gel, which we used as a positive control in the present study.…”

The effects of a tea tree oil‐containing gel on plaque and chronic gingivitis

“…[8][9][10][11][12] TTO shares a similar range of antimicrobial activity with chlorhexidine (CHX), although their mechanisms of action differ. 9,[12][13][14][15][16][17][18] They both have antibacterial, antiviral and antifungal properties. TTO has the potential to be a therapeutic agent in chronic gingivitis and periodontitis, conditions that have both bacterial and inflammatory components.…”

The Importance and Possibilities of Proper Oral Hygiene in Orthodontic Patients

“…It was also published that the effect of CHX gel is increased with combined use of fluoride gel (Ostela & Tenovuo, 1990;Meurman, 1988). In addition to the antibacterial CHX (0.11%), Cervitec gel (Vivadent, Schaan, Liechtenstein) containing fluoride (900 ppm) which promotes remineralization and protects the teeth from caries.…”