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Cited by 11 publications
(4 citation statements)
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“…The compounds 7a − h , 8 , and 9a exhibited extremely high antibacterial activity against the Gram-negative test strains, by far exceeding the activity of the ampicillin moiety, azlocillin, and partly also the activity of meropenem, especially against S. maltophilia. As known from literature, the increase in activity against Gram-negative bacteria is more or less at the expense of activity against Gram-positive S. aureus . , An exception is the derivative 7k based on 2-[ N -(aminobutyl)aminomethyl]benzoic acid, which inhibited both Gram-positive and Gram-negative strains. The 3,5-diaminobenzoic acid derivatives 12 , 14a − c , and 15c generally had a lower antibacterial activity than the derivatives 7 − 9 based on N -(aminoalkyl)amino acids.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…The compounds 7a − h , 8 , and 9a exhibited extremely high antibacterial activity against the Gram-negative test strains, by far exceeding the activity of the ampicillin moiety, azlocillin, and partly also the activity of meropenem, especially against S. maltophilia. As known from literature, the increase in activity against Gram-negative bacteria is more or less at the expense of activity against Gram-positive S. aureus . , An exception is the derivative 7k based on 2-[ N -(aminobutyl)aminomethyl]benzoic acid, which inhibited both Gram-positive and Gram-negative strains. The 3,5-diaminobenzoic acid derivatives 12 , 14a − c , and 15c generally had a lower antibacterial activity than the derivatives 7 − 9 based on N -(aminoalkyl)amino acids.…”
Section: Resultsmentioning
confidence: 99%
“…As known from literature, the increase in activity against Gram-negative bacteria is more or less at the expense of activity against Gram-positive S. aureus. 17,18 An exception is the derivative 7k based on 2-[N-(aminobutyl)aminomethyl]benzoic acid, which inhibited both Gram-positive and Gram-negative strains. The 3,5diaminobenzoic acid derivatives 12, 14a-c, and 15c generally had a lower antibacterial activity than the derivatives 7-9 based on N-(aminoalkyl)amino acids.…”
Section: Synthesis Of the β-Lactammentioning
confidence: 99%
“…Die Olivansäuren wurden im Zuge eines Screenings bei der Suche nach b-Lactamase-Inhibitoren aus Streptomyces olivaceus entdeckt. Diese cis-substituierten b-Lactame weisen zusätzlich zu ihrer Hemmwirkung gegen b-Lactamasen ein breites antibakterielles Spektrum auf, [197] [198] kurz danach wurde auch seine erste Totalsynthese beschrieben. [199] Die basische Amidinogruppe von Imipenem (44) liegt bei physiologischem pH-Wert protoniert vor, wodurch 44 deutlich beständiger wird als der Naturstoff 54.…”
Section: Angewandte Chemieunclassified
“…This "Trojan horse" approach is based on molecules found in nature, such as albomycins, which contain an iron-binding domain (similar to ferrichrome) and a toxic molecule. These complexes show excellent anti-Pseudomonas activity in vitro and in several animal infection models (Basker et al 1984(Basker et al , 1989Budzikiewicz 2001). Once internalized, the toxic molecule is cleaved and damages the cell (Benz et al 1982).…”
Section: Iron Metabolism As An Antibiofilm Targetmentioning
confidence: 99%